2014
Sex Differences in Guanfacine Effects on Drug Craving and Stress Arousal in Cocaine-Dependent Individuals
Fox HC, Morgan PT, Sinha R. Sex Differences in Guanfacine Effects on Drug Craving and Stress Arousal in Cocaine-Dependent Individuals. Neuropsychopharmacology 2014, 39: 1527-1537. PMID: 24395021, PMCID: PMC3988558, DOI: 10.1038/npp.2014.1.Peer-Reviewed Original ResearchConceptsCocaine use disorderImagery conditionNegative emotionsDrug cravingUse disordersCocaine-dependent individualsCocaine-dependent malesCocaine-dependent menSex differencesGuanfacine's effectsDrug cuesImagery exposureNegative moodSystolic blood pressureStress arousalNicotine cravingAlcohol cravingCounterbalanced orderCravingCocaine cravingAnxietyCocaine addictionEmotionsRecovery time pointsGuanfacine
2012
Stress system changes associated with marijuana dependence may increase craving for alcohol and cocaine
Fox HC, Tuit KL, Sinha R. Stress system changes associated with marijuana dependence may increase craving for alcohol and cocaine. Human Psychopharmacology Clinical And Experimental 2012, 28: 40-53. PMID: 23280514, PMCID: PMC3660143, DOI: 10.1002/hup.2280.Peer-Reviewed Original ResearchConceptsAlcohol cravingCue-related cravingTreatment-seeking individualsStress-induced cortisolMeasures of cravingCue-induced anxietyMarijuana relapseMotivational processesImagery conditionAnxiety ratingsDrugs of abuseMarijuana dependenceEarly abstinenceCravingCocaine cravingMarijuana abuseAnxietyLittle researchCardiovascular outputRecovery time pointsCuesDependent groupInpatient treatmentAbuseHealthy controls