2024
Substance use patterns, quantities, and associated risk factors in women with polysubstance misuse
Fogelman N, Tate M, Wemm S, Sullivan L, Hart R, Vacey E, Fox H, Sinha R. Substance use patterns, quantities, and associated risk factors in women with polysubstance misuse. Addiction Biology 2024, 29: 10.1111/adb.13390. PMID: 38619491, PMCID: PMC11017971, DOI: 10.1111/adb.13390.Peer-Reviewed Original ResearchConceptsPolysubstance useDepressive symptomsSubstance use patternsDrug cravingRisk factorsPatterns of polysubstance useSingle substance useAssociated with polysubstance usePlacebo-controlled studyHigher cravingGuanfacine treatmentCross-sectional observational studyPolysubstance use patternsCraving managementLife eventsCravingPolysubstance misuseSubstance useOpioid amountsPain ratingsStress/traumaObservational studyAnxietyPainPolysubstance
2014
Sex Differences in Guanfacine Effects on Drug Craving and Stress Arousal in Cocaine-Dependent Individuals
Fox HC, Morgan PT, Sinha R. Sex Differences in Guanfacine Effects on Drug Craving and Stress Arousal in Cocaine-Dependent Individuals. Neuropsychopharmacology 2014, 39: 1527-1537. PMID: 24395021, PMCID: PMC3988558, DOI: 10.1038/npp.2014.1.Peer-Reviewed Original ResearchConceptsCocaine use disorderImagery conditionNegative emotionsDrug cravingUse disordersCocaine-dependent individualsCocaine-dependent malesCocaine-dependent menSex differencesGuanfacine's effectsDrug cuesImagery exposureNegative moodSystolic blood pressureStress arousalNicotine cravingAlcohol cravingCounterbalanced orderCravingCocaine cravingAnxietyCocaine addictionEmotionsRecovery time pointsGuanfacine
2012
Stress system changes associated with marijuana dependence may increase craving for alcohol and cocaine
Fox HC, Tuit KL, Sinha R. Stress system changes associated with marijuana dependence may increase craving for alcohol and cocaine. Human Psychopharmacology Clinical And Experimental 2012, 28: 40-53. PMID: 23280514, PMCID: PMC3660143, DOI: 10.1002/hup.2280.Peer-Reviewed Original ResearchConceptsAlcohol cravingCue-related cravingTreatment-seeking individualsStress-induced cortisolMeasures of cravingCue-induced anxietyMarijuana relapseMotivational processesImagery conditionAnxiety ratingsDrugs of abuseMarijuana dependenceEarly abstinenceCravingCocaine cravingMarijuana abuseAnxietyLittle researchCardiovascular outputRecovery time pointsCuesDependent groupInpatient treatmentAbuseHealthy controls
2011
Prazosin Effects on Stress‐ and Cue‐Induced Craving and Stress Response in Alcohol‐Dependent Individuals: Preliminary Findings
Fox HC, Anderson GM, Tuit K, Hansen J, Kimmerling A, Siedlarz KM, Morgan PT, Sinha R. Prazosin Effects on Stress‐ and Cue‐Induced Craving and Stress Response in Alcohol‐Dependent Individuals: Preliminary Findings. Alcohol Clinical And Experimental Research 2011, 36: 351-360. PMID: 21919922, PMCID: PMC3243763, DOI: 10.1111/j.1530-0277.2011.01628.x.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-1 Receptor AntagonistsAdultAlcoholismAnxietyBlood PressureCuesDiagnostic and Statistical Manual of Mental DisordersDouble-Blind MethodEmotionsFemaleHemodynamicsHumansHypothalamo-Hypophyseal SystemImaginationMalePituitary-Adrenal SystemPrazosinSecondary PreventionStress, PsychologicalConceptsCue-induced alcohol cravingNegative emotionsAlcohol-dependent individualsBlunted HPA responseAlcohol cravingAlcohol cuesStress dysregulationTreatment-seeking alcohol-dependent individualsCue-induced alcoholAlcohol cue exposureCue-Induced CravingImagery exposureBlood pressureHPA responseLower alcohol cravingCue exposureRelapse susceptibilityPreliminary efficacy studyEmotionsPrazosin groupPlacebo groupCravingCounterbalanced orderControl conditionAnxiety