Featured Publications
Placental Pathology Findings in Unexplained Pregnancy Losses
Thompson B, Holzer P, Kliman H. Placental Pathology Findings in Unexplained Pregnancy Losses. Reproductive Sciences 2023, 31: 488-504. PMID: 37725247, PMCID: PMC10827979, DOI: 10.1007/s43032-023-01344-3.Peer-Reviewed Original ResearchWeeks of gestationCommon pathologic featureSmall placentaPathologic featuresPregnancy lossChorionic villiPlacental pathology findingsUnexplained lossUnexplained pregnancy lossAntepartum stillbirthPlacental examinationUnexplained stillbirthPathology findingsUnexplained miscarriagePrevalent abnormalityPathologic diagnosisClinical databaseStillbirthMiscarriagePathology slidesDiagnostic categoriesGenetic abnormalitiesClassification systemPlacentaPotential mechanisms
2021
Genetics, not the uterine environment, drive the formation of trophoblast inclusions: Insights from a twin study
Katz J, Holzer PH, Kliman HJ. Genetics, not the uterine environment, drive the formation of trophoblast inclusions: Insights from a twin study. Placenta 2021, 114: 133-138. PMID: 33941390, DOI: 10.1016/j.placenta.2021.04.010.Peer-Reviewed Original ResearchConceptsMean differenceUterine environmentTwin pairsTrophoblast inclusionsRetrospective case seriesCase seriesPregnancy lossIntrauterine environmentFetal geneticsMZ twinsDZ twinsDizygotic twin pairsMZ twin pairsGenetic abnormalitiesPlacentaZygosity groupsTwin individualsAverage numberMonozygoticTwin studiesMean absolute differenceAbsolute differenceDifferencesGroupFetuses
2019
Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy
Tal R, Shaikh S, Pallavi P, Tal A, López-Giráldez F, Lyu F, Fang YY, Chinchanikar S, Liu Y, Kliman HJ, Alderman M, Pluchino N, Kayani J, Mamillapalli R, Krause DS, Taylor HS. Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy. PLOS Biology 2019, 17: e3000421. PMID: 31513564, PMCID: PMC6742226, DOI: 10.1371/journal.pbio.3000421.Peer-Reviewed Original ResearchConceptsBM transplantsDecidual cellsPregnancy lossMesenchymal stem cellsAdult bone marrow progenitorsDecidualization-related genesBone marrow progenitorsAdult bone marrowWT donorsPhysiologic contributionSuccessful pregnancyBMDC recruitmentStromal expansionImmune cellsEndometrial cellsDeficient miceUterine expressionUterine tissueDecidual stromaPregnancyBone marrowNonhematopoietic cellsBMDCsHemochorial placentaMarrow progenitors
2017
Luteal start vaginal micronized progesterone improves pregnancy success in women with recurrent pregnancy loss
Stephenson MD, McQueen D, Winter M, Kliman HJ. Luteal start vaginal micronized progesterone improves pregnancy success in women with recurrent pregnancy loss. Fertility And Sterility 2017, 107: 684-690.e2. PMID: 28081870, DOI: 10.1016/j.fertnstert.2016.11.029.Peer-Reviewed Original ResearchConceptsPregnancy successEndometrial biopsySubsequent pregnancyLH surgePregnancy lossVaginal micronized progesteroneObservational cohort studyUnexplained pregnancy lossRecurrent pregnancy lossCohort of womenCyclin E expressionMicronized progesteronePrior pregnancyCohort studyOngoing pregnancyConcomitant findingsEndometrial glandsOdds ratioInclusion criteriaMAIN OUTCOMEPregnancyE expressionWomenCohortWeeks
2009
Abnormal nuclear cyclin E expression in endometrial glands of patients with recurrent pregnancy loss (RPL): response to vaginal micronized progesterone adminstration
Stephenson M, Willis M, Schultz P, Milano K, Kliman H. Abnormal nuclear cyclin E expression in endometrial glands of patients with recurrent pregnancy loss (RPL): response to vaginal micronized progesterone adminstration. Fertility And Sterility 2009, 92: s244-s245. DOI: 10.1016/j.fertnstert.2009.07.1612.Peer-Reviewed Original Research
2004
Successful treatment of endometrial-associated recurrent pregnancy loss (RPL): A blinded, controlled study
Stephenson M, Houlihan E, Karrison T, Franco A, McSweet J, Kliman H. Successful treatment of endometrial-associated recurrent pregnancy loss (RPL): A blinded, controlled study. Fertility And Sterility 2004, 82: s79. DOI: 10.1016/j.fertnstert.2004.07.201.Peer-Reviewed Original Research