2023
Chronic use of benzodiazepines: The problem that persists
Louie D, Jegede O, Hermes G. Chronic use of benzodiazepines: The problem that persists. The International Journal Of Psychiatry In Medicine 2023, 58: 426-432. PMID: 36972700, DOI: 10.1177/00912174231166252.Peer-Reviewed Original Research
2022
Martha K. McClintock
Hermes G. Martha K. McClintock. 2022, 359-383. DOI: 10.1007/978-3-031-12970-4_36.Peer-Reviewed Original ResearchPregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder
Milivojevic V, Sullivan L, Tiber J, Fogelman N, Simpson C, Hermes G, Sinha R. Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder. Psychopharmacology 2022, 240: 101-114. PMID: 36445398, PMCID: PMC10630889, DOI: 10.1007/s00213-022-06278-3.Peer-Reviewed Original ResearchConceptsAlcohol use disorderDiastolic blood pressureHeart rateGABAergic transmissionNeuroactive steroidsHPA axisRelapse riskUse disordersAlcohol cravingTreatment of AUDAlcohol cue-induced cravingPilot clinical trialStress-induced anxietyCue-induced cravingAutonomic arousalNeurosteroid systemPreg groupStudy drugDBP responseBlood pressureDay groupClinical trialsPregnenolone levelsWeek 2Cue-provoked cravingPregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
Milivojevic V, Charron L, Fogelman N, Hermes G, Sinha R. Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder. Biomolecules 2022, 12: 1593. PMID: 36358943, PMCID: PMC9687893, DOI: 10.3390/biom12111593.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureCocaine use disorderHeart ratePrecursor pregnenoloneUse disordersCocaine cravingCue-induced cocaine cravingCue-induced anxietyWeeks of treatmentCue-induced cravingAutonomic arousalChronic cocaine usePreg groupBlood pressureDay groupRelapse riskHigher cocainePregnenolone levelsCue-provoked cravingSeparate daysAutonomic responsesCocaine useTreatment-seeking individualsCravingSteroid systems
2018
98. Effects of Childhood Maltreatment on Neural and Biobehavioral Biomarkers of Relapse and Recovery in Substance Use Disorders
Sinha R, Seo D, Lacadie C, Constable T, Hermes G. 98. Effects of Childhood Maltreatment on Neural and Biobehavioral Biomarkers of Relapse and Recovery in Substance Use Disorders. Biological Psychiatry 2018, 83: s40. DOI: 10.1016/j.biopsych.2018.02.116.Peer-Reviewed Original Research
2016
Ketamine’s Mechanisms of Rapid Antidepressant Activity: Evidence from Preclinical Studies
Hermes G, Sanacora G. Ketamine’s Mechanisms of Rapid Antidepressant Activity: Evidence from Preclinical Studies. 2016, 73-98. DOI: 10.1007/978-3-319-42925-0_6.Peer-Reviewed Original ResearchAntidepressant activityPreclinical studiesAntidepressant actionKetamine's mechanismPreclinical literatureRodent modelsRapid onsetBrain-derived neurotrophic factor (BDNF) expressionBehavioral effectsClassic antidepressant drugsRapid antidepressant activityNeurotrophic factor expressionChronic stressor exposureReceptor-targeted drugsNovel drug developmentAntidepressant propertiesKetamine effectsClinical trialsAntidepressant drugsSynaptic plasticityReceptor activationClinical settingFactor expressionStressor exposureDurable effectsRole of mitochondrial uncoupling protein-2 (UCP2) in higher brain functions, neuronal plasticity and network oscillation
Hermes G, Nagy D, Waterson M, Zsarnovszky A, Varela L, Hajos M, Horvath TL. Role of mitochondrial uncoupling protein-2 (UCP2) in higher brain functions, neuronal plasticity and network oscillation. Molecular Metabolism 2016, 5: 415-421. PMID: 27257601, PMCID: PMC4877662, DOI: 10.1016/j.molmet.2016.04.002.Peer-Reviewed Original ResearchMouse modelSynaptic plasticityMental illnessUCP2 knockout miceNMDA receptor blockadeHigher brain regionsKO mouse modelMajor psychiatric illnessProtein 2 expressionHigher brain functionsReceptor blockadePsychiatric illnessNeuronal plasticityKnockout miceNeural transmissionCellular resilienceCortical activityBrain regionsProfound disorderBrain functionMitochondrial impairmentIllnessNetwork oscillationsMitochondrial functionProtein 2- Hermes, Gretchen and Gerard Sanacora, "Ketamine’s Mechanism of Rapid Antidepressant Activity: Evidence from Preclinical Studies." In Ketamine for Treatment-Resistant Depression: The First Decade of Progress, eds. Sanjay J. Mathew and Carlos A. Zarate Jr. Springer International Publishing, 2016.Peer-Reviewed Original Research
2015
Neural plasticity in hypocretin neurons: the basis of hypocretinergic regulation of physiological and behavioral functions in animals
Gao XB, Hermes G. Neural plasticity in hypocretin neurons: the basis of hypocretinergic regulation of physiological and behavioral functions in animals. Frontiers In Systems Neuroscience 2015, 9: 142. PMID: 26539086, PMCID: PMC4612503, DOI: 10.3389/fnsys.2015.00142.Peer-Reviewed Original ResearchHypocretin systemNormal physiological functionPhysiological functionsNeural plasticityHypocretin-containing neuronsPF/LHSubstantial plastic changesCritical brain functionsPathological conditionsLong-term behavioral changesHypocretin neuronsLateral hypothalamusDaily functionNeuronal activityPlastic changesLong-term changesPlasticityMental health implicationsNeuronal systemsRecent evidenceBrain functionBehavioral functionsNeural activityHealth implicationsDaily fluctuations
2012
Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior
Simon-Areces J, Dietrich MO, Hermes G, Garcia-Segura LM, Arevalo MA, Horvath TL. Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior. PLOS ONE 2012, 7: e42911. PMID: 22905184, PMCID: PMC3414493, DOI: 10.1371/journal.pone.0042911.Peer-Reviewed Original ResearchConceptsUCP2 expressionCellular stressHippocampal neuronsChemical inhibitionMitochondrial bioenergeticsNeuronal differentiationGenetic ablationNatural birthProtein 2Adult behaviorCell proliferationCritical roleAdult brainNeuronal numberExpressionBioenergeticsNeuronsBirthDifferentiationRegulationProliferationSynaptogenesisVitroNeuroprotectionHippocampus
2011
Identification of a Sporozoite-Specific Antigen from Toxoplasma gondii
Hill D, Coss C, Dubey J, Wroblewski K, Sautter M, Hosten T, Muñoz-Zanzi C, Mui E, Withers S, Boyer K, Hermes G, Coyne J, Jagdis F, Burnett A, McLeod P, Morton H, Robinson D, McLeod R. Identification of a Sporozoite-Specific Antigen from Toxoplasma gondii. Journal Of Parasitology 2011, 97: 328-337. PMID: 21506817, PMCID: PMC3684278, DOI: 10.1645/ge-2782.1.Peer-Reviewed Original ResearchConceptsDetectable antibodiesToxoplasma gondiiEarly T. gondii infectionWestern blotT. gondii infectionRoute of infectionT. gondii sporozoitesAgents of infectionAcute stageChronic stageGondii infectionSerum antibodiesEpidemiological dataUninfected individualsInfection routeSerological assaysInfectionSporozoite-specific proteinsPrevious exposureAntibodiesReduction of riskAnimal infectionsPredominant routeDifference gel electrophoresisTandem mass spectroscopy
2010
Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats
Hermes G, Li N, Duman C, Duman R. Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats. Physiology & Behavior 2010, 104: 354-359. PMID: 21185848, PMCID: PMC3387788, DOI: 10.1016/j.physbeh.2010.12.019.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAnimals, NewbornBehavioral SymptomsBody WeightDisks Large Homolog 4 ProteinEstriolEstrusExploratory BehaviorFemaleFood DeprivationGene Expression Regulation, DevelopmentalIntracellular Signaling Peptides and ProteinsMembrane ProteinsPrefrontal CortexPregnancyRatsRats, Sprague-DawleyReceptors, AMPAReceptors, N-Methyl-D-AspartateSocial IsolationSynapsinsConceptsFemale ratsNovelty-suppressed feeding testPrefrontal cortexSocial isolationPost-weaning social isolationSynapse-related proteinsChronic social isolationFemale Sprague-DawleyEarly life stressorsSerotonergic functionGlutamate receptorsSprague-DawleyMale rodentsMaternal separationProtein PSD95Profound dysregulationNeuropsychiatric disordersBrain developmentRatsAnxiety disordersMarked deficitDeprivation resultsProtein expressionAdult animalsBiochemical effects
2009
Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors
Hermes GL, Delgado B, Tretiakova M, Cavigelli SA, Krausz T, Conzen SD, McClintock MK. Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 22393-22398. PMID: 20018726, PMCID: PMC2799783, DOI: 10.1073/pnas.0910753106.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingCorticosteroneEndocrine GlandsFemaleHumansMammary Neoplasms, ExperimentalOvaryRatsRats, Sprague-DawleyReceptors, GlucocorticoidRisk FactorsSocial EnvironmentSocial IsolationStress, PhysiologicalStress, PsychologicalConceptsDuctal carcinomaBreast cancerCorticosterone responseTumor developmentMammary tumor burdenProgesterone receptor statusEarly breast cancerMammary tumor growthInvasive ductal carcinomaSprague-Dawley ratsMammary tumor progressionAge-matched controlsSpontaneous mammary tumorsLife Span StudyMalignant burdenTumor estrogenReceptor statusTumor burdenOvarian functionFemale ratsMammary tumorsRelative riskTumor growthPsychosocial stressorsTumor progression
2008
Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection
Hermes G, Ajioka JW, Kelly KA, Mui E, Roberts F, Kasza K, Mayr T, Kirisits MJ, Wollmann R, Ferguson D, Roberts CW, Hwang JH, Trendler T, Kennan RP, Suzuki Y, Reardon C, Hickey WF, Chen L, McLeod R. Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection. Journal Of Neuroinflammation 2008, 5: 48. PMID: 18947414, PMCID: PMC2588578, DOI: 10.1186/1742-2094-5-48.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAtrophyBehavior, AnimalBiomarkersBrainCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChronic DiseaseDisease Models, AnimalEncephalitisFemaleLateral VentriclesMagnetic Resonance ImagingMiceMicrogliaNerve DegenerationNerve Tissue ProteinsNeuronsToxoplasmaToxoplasmosis, CerebralConceptsT. gondii infectionAqueduct of SylviusPerivascular inflammationVentricular dilatationGondii infectionResistant miceInflammatory cellsBrain weightBrain parenchymaBrain MRIBehavioral abnormalitiesChronic T. gondii infectionLower brain weightPersistent brain infectionBrains of micePD-1LResultsTwelve monthsNeurologic findingsNeurological deficitsNeuronal injuryStudy of markersNeurologic functionNeuronal damageBrain infectionFree tachyzoitesIsolation and the timing of mammary gland development, gonadarche, and ovarian senescence: Implications for mammary tumor burden
Hermes GL, McClintock MK. Isolation and the timing of mammary gland development, gonadarche, and ovarian senescence: Implications for mammary tumor burden. Developmental Psychobiology 2008, 50: 353-360. PMID: 18393277, DOI: 10.1002/dev.20295.Peer-Reviewed Original ResearchConceptsMammary tumor burdenTumor burdenOvarian functionMammary gland developmentOvarian systemGreater tumor burdenGland developmentSpontaneous mammary tumorsSocial isolationMammary tissue developmentRisk factorsBreast cancerMammary tumorsOvarian senescenceEpidemiological studiesBreast parenchymaEarly pubertyRatsYoung adulthoodNorway ratsPubertyPsychosocial experiencesBurdenAgeEstropause
2005
Social isolation and the inflammatory response: sex differences in the enduring effects of a prior stressor
Hermes GL, Rosenthal L, Montag A, McClintock MK. Social isolation and the inflammatory response: sex differences in the enduring effects of a prior stressor. AJP Regulatory Integrative And Comparative Physiology 2005, 290: r273-r282. PMID: 16210419, DOI: 10.1152/ajpregu.00368.2005.Peer-Reviewed Original ResearchConceptsChronic social isolationInflammatory responseSocial isolationAnimal studiesPrior stressorsInnate inflammatory responseRobust inflammatory responseNumerous epidemiological studiesFemale Sprague-DawleyLong-term social isolationFirst animal studyAdverse psychological statesSex differencesNumerous disease processesInflammatory processSubcutaneous injectionSprague-DawleyLong-term effectsEpidemiological studiesDisease processShort-term effectsAcute stressSignificant sex differencesYoung adulthoodIsolated malesThe sectored foraging field: A novel design to quantify spatial strategies, learning, memory, and emotion
Hermes GL, Jacobs LF, McClintock MK. The sectored foraging field: A novel design to quantify spatial strategies, learning, memory, and emotion. Neurobiology Of Learning And Memory 2005, 84: 69-73. PMID: 15936684, DOI: 10.1016/j.nlm.2005.02.001.Peer-Reviewed Original ResearchConceptsNatural learning contextSame motor actionAnalysis of cognitionLearning strategiesSpatial navigation taskSpatial strategiesDifferent learning strategiesKinesthetic strategyCognitive performanceCue removalMotor actionsDifferent social ecologiesGroup contextMultiple learning strategiesLearning contextNavigation taskSocial ecologySocial environmentLocal cuesEmotionsCognitionGroup-housed ratsGroup-housed malesStressful environmentsAdulthood
1997
Emotions and Disease Exhibtion Catalog
https://www.nlm.nih.gov/exhibition/emotions/Peer-Reviewed Original Research