2024
W74. MULTI-OMICS ANALYSIS OF INTERMEDIATE PHENOTYPES REVEALS NEW RISK GENES AND PATHWAYS IN PSYCHOTIC DISORDERS
Xia C, Alliey-Rodriguez N, Tamminga C, Keshavan M, Pearlson G, Keedy S, Parker D, Bishop J, Chen C, Liu C, Gershon E. W74. MULTI-OMICS ANALYSIS OF INTERMEDIATE PHENOTYPES REVEALS NEW RISK GENES AND PATHWAYS IN PSYCHOTIC DISORDERS. European Neuropsychopharmacology 2024, 87: 141-142. DOI: 10.1016/j.euroneuro.2024.08.283.Peer-Reviewed Original ResearchTranscriptome-wide association studyGenome-wide complex trait analysisPotential causal genesQuantitative Trait LociRisk genesEvent-related potentialsPolygenic risk scoresIntermediate phenotypesGene OntologyCase-control statusPsychotic disordersComplex trait analysisGenotype principal componentsIdentified risk genesGenetic correlationsMulti-omics analysisMendelian randomizationPRS-CSxPsychosis risk genesCausal genesAssociation studiesGenomic characteristicsDetect significant associationsGene associationsBipolar-Schizophrenia Network
2023
Double dissociation between P300 components and task switch error type in healthy but not psychosis participants
Huang L, Parker D, Ethridge L, Hamm J, Keedy S, Tamminga C, Pearlson G, Keshavan M, Hill S, Sweeney J, McDowell J, Clementz B. Double dissociation between P300 components and task switch error type in healthy but not psychosis participants. Schizophrenia Research 2023, 261: 161-169. PMID: 37776647, PMCID: PMC11015813, DOI: 10.1016/j.schres.2023.09.025.Peer-Reviewed Original ResearchConceptsEvent-related potentialsDouble dissociationParietal P300Oddball taskCognitive functionPsychosis participantsInductive reasoningP300 event-related potentialFrontal P300 amplitudePossible neural correlatesMental flexibilityCognitive demandsMemory maintenanceNeural correlatesPerseverative errorsRegressive errorsBehavioral performanceOddball targetsP300 componentP300 amplitudeError typesSubjects' abilityNeural activityP300 reductionHealthy participants
2021
Response Inhibition Circuit Dysregulation in Substance Use Disorders Identified With Event-Related Potential-Derived Functional Connectivity
Steele V, Tootell A, Butler D, Fix S, Stevens M, Pearlson G, Bernat E. Response Inhibition Circuit Dysregulation in Substance Use Disorders Identified With Event-Related Potential-Derived Functional Connectivity. Biological Psychiatry 2021, 89: s350. DOI: 10.1016/j.biopsych.2021.02.873.Peer-Reviewed Original ResearchSubstance use disordersCircuit dysregulationUse disordersFunctional connectivityEvent-related potentials