2024
Deciphering the effects of radiopharmaceutical therapy in the tumor microenvironment of prostate cancer: an in-silico exploration with spatial transcriptomics
Hong J, Bae S, Cavinato L, Seifert R, Ryhiner M, Rominger A, Erlandsson K, Wilks M, Normandin M, El-Fakhri G, Choi H, Shi K. Deciphering the effects of radiopharmaceutical therapy in the tumor microenvironment of prostate cancer: an in-silico exploration with spatial transcriptomics. Theranostics 2024, 14: 7122-7139. DOI: 10.7150/thno.99516.Peer-Reviewed Original Research
2018
Subject-specific brain tumor growth modelling via an efficient Bayesian inference framework
Chang Y, Sharp G, Li Q, Shih H, El Fakhri G, Ra J, Woo J. Subject-specific brain tumor growth modelling via an efficient Bayesian inference framework. Proceedings Of SPIE--the International Society For Optical Engineering 2018, 10574: 105742i. PMID: 30050231, PMCID: PMC6056378, DOI: 10.1117/12.2293145.Peer-Reviewed Original ResearchTumor growthOptimal treatmentExternal beam radiotherapyBrain tumor progressionBeam radiotherapyBrain tumor growthTumor growth modelTumor infiltrationTumor parametersTumor progressionEffective therapyClinical dataTherapy planningTumorIndividualized therapyTherapyTumor boundariesProliferation rateRadiotherapyNon-invasiveState-of-the-art methodsTreatmentState-of-the-artChemotherapy
2016
ORAL02.03: Robust Correlation Between Metabolic Response Measured with 18F-FDG PET Soon After Therapy and Clinical Outcome in Lung Cancer Topic: Radiation Oncology
Choi N, Gainor J, Ackman J, Lim R, Sharp G, Fakhri G, Niemierko A. ORAL02.03: Robust Correlation Between Metabolic Response Measured with 18F-FDG PET Soon After Therapy and Clinical Outcome in Lung Cancer Topic: Radiation Oncology. Journal Of Thoracic Oncology 2016, 11: s253-s254. DOI: 10.1016/j.jtho.2016.09.012.Peer-Reviewed Original ResearchInvestigation of cone-beam CT image quality trade-off for image-guided radiation therapy
Bian J, Sharp G, Park Y, Ouyang J, Bortfeld T, Fakhri G. Investigation of cone-beam CT image quality trade-off for image-guided radiation therapy. Physics In Medicine And Biology 2016, 61: 3317-3346. PMID: 27032676, DOI: 10.1088/0031-9155/61/9/3317.Peer-Reviewed Original ResearchConceptsImage-guided radiation therapyCone-beam CTFiltered-backprojectionImage quality trade-offConventional filtered-backprojectionShort-scan reconstructionsFiltered-backprojection algorithmFan-beam reconstructionTV-based algorithmIterative reconstruction algorithmCatphan phantomRadiation therapyAngular rangeTotal-variationOptimal exposure levelClinical scannerScanning configurationReconstruction algorithmImaging conditionsCatphanPhantomExposure levelsTherapyConfigurationRange
2015
Improved Local Tumor Control With Supplementary Dose of Radiation Guided by 18F-FDG PET Soon After Standard Dose Radiation Therapy and Concurrent Chemotherapy in Inoperable Stages II and III Non-Small Cell Lung Cancer
Choi N, Gainor J, Ackman J, Lim R, Sharp G, Fakhri G, Niemierko A. Improved Local Tumor Control With Supplementary Dose of Radiation Guided by 18F-FDG PET Soon After Standard Dose Radiation Therapy and Concurrent Chemotherapy in Inoperable Stages II and III Non-Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e438-e439. DOI: 10.1016/j.ijrobp.2015.07.1664.Peer-Reviewed Original ResearchMonitoring proton therapy with PET
Paganetti H, Fakhri G. Monitoring proton therapy with PET. British Journal Of Radiology 2015, 88: 20150173. PMID: 25989699, PMCID: PMC4628541, DOI: 10.1259/bjr.20150173.Peer-Reviewed Original ResearchConceptsPatient set-upDose conformityDose shapingInterfractional changesProton beamBeam deliveryDose calculationProton therapyTumor coveragePhotonic techniquesTreatment volumeTotal energyPatient anatomyBeamRadiation therapyProtonPatientsTherapyReduced total energyDoseSet-upRangeCalculationsRadiationEnergy
2013
Proton Therapy Verification with PET Imaging
Zhu X, Fakhri G. Proton Therapy Verification with PET Imaging. Theranostics 2013, 3: 731-740. PMID: 24312147, PMCID: PMC3840408, DOI: 10.7150/thno.5162.Peer-Reviewed Original Research
2012
In Vivo Treatment Verification Using In-room PET in Proton Radiation Therapy: First Clinical Trials and Evaluation of Short-length Scan
Min C, Zhu X, Winey B, Grogg K, Fakhri G, Bortfeld T, Paganetti H, Shih H. In Vivo Treatment Verification Using In-room PET in Proton Radiation Therapy: First Clinical Trials and Evaluation of Short-length Scan. International Journal Of Radiation Oncology • Biology • Physics 2012, 84: s53-s54. DOI: 10.1016/j.ijrobp.2012.07.347.Peer-Reviewed Original Research