2024
PET motion correction using subspace-based real-time MR imaging in simultaneous PET/MR
Mounime I, Marin T, Han P, Ouyang J, Gori P, Angelini E, Fakhri G, Ma C. PET motion correction using subspace-based real-time MR imaging in simultaneous PET/MR. 2024, 00: 1-1. DOI: 10.1109/nss/mic/rtsd57108.2024.10657647.Peer-Reviewed Original ResearchOrdered-subset expectation maximizationMotion correctionGated reconstructionsMotion-corrected PET reconstructionsPET eventsCardiac motion phasesMotion correction methodCardiac motionMotion phaseReconstructed dynamic imagesPET reconstructionReal-time MR imagingSimultaneous PET/MRPatient motionSoft tissue contrastDynamic MR image reconstructionReference phaseMitigate artifactsLow-rank propertyMR image reconstructionPositron emission tomographyManifold learning frameworkSpatial resolutionBlurring artifactsImage reconstructionEffects of List-Mode-Based Intraframe Motion Correction in Dynamic Brain PET Imaging
Tiss A, Chemli Y, Guehl N, Marin T, Johnson K, Fakhri G, Ouyang J. Effects of List-Mode-Based Intraframe Motion Correction in Dynamic Brain PET Imaging. IEEE Transactions On Radiation And Plasma Medical Sciences 2024, 8: 950-958. PMID: 39507127, PMCID: PMC11540417, DOI: 10.1109/trpms.2024.3432322.Peer-Reviewed Original Research
2023
Impact of motion correction on [18F]-MK6240 tau PET imaging
Tiss A, Marin T, Chemli Y, Spangler-Bickell M, Gong K, Lois C, Petibon Y, Landes V, Grogg K, Normandin M, Becker A, Thibault E, Johnson K, Fakhri G, Ouyang J. Impact of motion correction on [18F]-MK6240 tau PET imaging. Physics In Medicine And Biology 2023, 68: 105015. PMID: 37116511, PMCID: PMC10278956, DOI: 10.1088/1361-6560/acd161.Peer-Reviewed Original ResearchConceptsMotion correctionPET quantitationImpact of motion correctionList-mode reconstructionMotion correction methodList-mode dataMotion-corrected imagesEffect of motion correctionVoxel displacementsPhantom experimentsOptical tracking dataLong acquisitionBrain PET scansSlow motionImage qualityPET imagingPositron emission tomographyCorrectionMotionCorrection methodRates of tau accumulationHead motionMotion metricsPhantomPositron
2022
Cardiac PET/MR Basics
Petibon Y, Ma C, Ouyang J, El Fakhri G. Cardiac PET/MR Basics. 2022, 21-35. DOI: 10.1007/978-3-031-09807-9_2.Peer-Reviewed Original ResearchMeasuring organ motionPET motion correctionFront-end electronicsScintillation detectorOrgan motionMotion correctionAttenuation correctionPET/MR scannersAbility of MRISimultaneous imaging modalityPET/MR technologyAttenuation propertiesHybrid PET/MR scannerPET/MRPre-clinicalImaging modalitiesClinical applicationMRIOrgan systemsCardiac applicationsImaging opportunitiesCorrectionDetectorSpatiotemporal resolutionElectron
2020
Motion correction for PET data using subspace-based real-time MR imaging in simultaneous PET/MR
Marin T, Djebra Y, Han P, Chemli Y, Bloch I, Fakhri G, Ouyang J, Petibon Y, Ma C. Motion correction for PET data using subspace-based real-time MR imaging in simultaneous PET/MR. Physics In Medicine And Biology 2020, 65: 235022. PMID: 33263317, PMCID: PMC7985095, DOI: 10.1088/1361-6560/abb31d.Peer-Reviewed Original ResearchConceptsPositron emission tomography reconstructionMotion-corrected PET reconstructionsPET reconstructionMotion-corrected PET imagesIrregular respiratory motionMotion fieldMotion correction methodMotion correction approachIrregular motion patternsUndersampled k-space dataImage quality of positron emission tomographyQuality of positron emission tomographyMotion patternsLow-rank characteristicsRespiratory motionContrast-to-noise ratioEstimated motion fieldSurrogate signalsMotion correctionK-space dataImage qualityReal-time MR imagingSimultaneous PET/MRMotion artifact reductionPET/MR scanners
2019
Body motion detection and correction in cardiac PET: Phantom and human studies
Sun T, Petibon Y, Han P, Ma C, Kim S, Alpert N, Fakhri G, Ouyang J. Body motion detection and correction in cardiac PET: Phantom and human studies. Medical Physics 2019, 46: 4898-4906. PMID: 31508827, PMCID: PMC6842053, DOI: 10.1002/mp.13815.Peer-Reviewed Original ResearchConceptsList-mode dataMotion-compensated image reconstructionMotion correctionCenter of massPET list-mode dataMotion correction methodMotion detectionMotion estimationImage reconstructionPatient body motionDegrade image qualityNonrigid registrationImage qualityMotion transformationCoincident distributionBody motion detectionCardiac positron emission tomographyBack-projection techniqueCovariance matrixImage volumesBody motionPositron emission tomographyBack-projectionReference framePhantomMR-based cardiac and respiratory motion correction of PET: application to static and dynamic cardiac 18F-FDG imaging
Petibon Y, Sun T, Han P, Ma C, Fakhri G, Ouyang J. MR-based cardiac and respiratory motion correction of PET: application to static and dynamic cardiac 18F-FDG imaging. Physics In Medicine And Biology 2019, 64: 195009. PMID: 31394518, PMCID: PMC7007962, DOI: 10.1088/1361-6560/ab39c2.Peer-Reviewed Original ResearchConceptsMR-based motion correctionRespiratory motion correctionMotion correctionImproved spatial resolutionReconstructed activity concentrationCardiac PET dataSpatial resolutionCoincidence eventsMR-basedPET imagingContrast-to-noise ratioCardiac PET imagingRespiratory phasesMC dataImprove image qualityMR acquisitionQuantitative accuracyCardiac PETPET dataActivity concentrationsMyocardium wallF-FDG PETDynamics studiesImage qualityMotion artifactsBulk motion detection and correction using list-mode data for cardiac PET imaging
Sun T, Petibon Y, Han P, Ma C, Kim S, Alpert N, Fakhri G, Ouyang J. Bulk motion detection and correction using list-mode data for cardiac PET imaging. Proceedings Of SPIE--the International Society For Optical Engineering 2019, 11072: 110722f-110722f-5. DOI: 10.1117/12.2534701.Peer-Reviewed Original ResearchList-mode dataCardiac PET imagingPET list-mode dataMotion-corrected imagesLines of responsePET imaging applicationsCardiac PETImage qualityBulk motionCardiac PET studiesMotion correctionPET imagingBrain PETMotion estimationData-driven approachMotion detectionImaging applicationsImage spaceMoving frameStatic reference frameMotion transformationCorrectionCenter positionMotionReference frame
2018
MR-based motion correction for cardiac PET parametric imaging: a simulation study
Guo R, Petibon Y, Ma Y, El Fakhri G, Ying K, Ouyang J. MR-based motion correction for cardiac PET parametric imaging: a simulation study. EJNMMI Physics 2018, 5: 3. PMID: 29388075, PMCID: PMC5792384, DOI: 10.1186/s40658-017-0200-9.Peer-Reviewed Original ResearchNon-motion-correctedPositron emission tomography-magnetic resonanceMR-based motion correctionRespiratory motionMotion correctionActivity distributionMotion correction methodRespiratory gatingPET sinogramsNoise levelCardiac gatingMRI simulationOne-tissue compartment modelNoise realizationsMC methodPET dataCardiac motionReduce motion blurParametric imagesIncreased noise levelConclusionsThis simulation studyArterial input functionPET imagingGateMyocardial regions
2017
Magnetic Resonance–based Motion Correction for Quantitative PET in Simultaneous PET-MR Imaging
Rakvongthai Y, Fakhri G. Magnetic Resonance–based Motion Correction for Quantitative PET in Simultaneous PET-MR Imaging. PET Clinics 2017, 12: 321-327. PMID: 28576170, PMCID: PMC6452624, DOI: 10.1016/j.cpet.2017.02.004.Peer-Reviewed Original ResearchConceptsSimultaneous PET-MRQuantitative PET imagingMotion correctionSimultaneous PET-MR imagingReconstructed PET imagesMotion-corrected imagesPET-MRMotion correction strategiesPET imagingPET-MR imagingQuantitation of PET imagesPatient studiesQuantitative PETImage qualityMotionCorrectionPhantomAnatomical informationCorrection strategyMR imaging
2016
Impact of motion and partial volume effects correction on PET myocardial perfusion imaging using simultaneous PET-MR
Petibon Y, Guehl N, Reese T, Ebrahimi B, Normandin M, Shoup T, Alpert N, Fakhri G, Ouyang J. Impact of motion and partial volume effects correction on PET myocardial perfusion imaging using simultaneous PET-MR. Physics In Medicine And Biology 2016, 62: 326-343. PMID: 27997375, PMCID: PMC5241952, DOI: 10.1088/1361-6560/aa5087.Peer-Reviewed Original ResearchConceptsSimultaneous PET-MRPET myocardial perfusion imagingMyocardial perfusion imagingPoint spread functionPoint-spread function correctionUngated dataMotion correctionPET-MRPartial volume effectsApparent wall thicknessMyocardial blood flowPartial volume effect correctionMR-based motion correctionMotion fieldPET-MR scannersPoint spread function modelPET dataPerfusion imagingImage qualityImpact of motionDynamic myocardial perfusion imagingAttenuation mapNon-rigid registrationAbsolute myocardial blood flowUngated images
2015
Accelerated acquisition of tagged MRI for cardiac motion correction in simultaneous PET‐MR: Phantom and patient studies
Huang C, Petibon Y, Ouyang J, Reese T, Ahlman M, Bluemke D, El Fakhri G. Accelerated acquisition of tagged MRI for cardiac motion correction in simultaneous PET‐MR: Phantom and patient studies. Medical Physics 2015, 42: 1087-1097. PMID: 25652521, PMCID: PMC4312342, DOI: 10.1118/1.4906247.Peer-Reviewed Original ResearchConceptsPET motion correctionMotion correctionSimultaneous PET-MRTMR dataPET list-mode dataPET-MRList-mode dataCardiac motion correctionPET-MR scannersImage qualityParallel imagingAcquisition timePET imagingRespiratory motionCompressive sensingMotion fieldAttenuation correctionDefect contrastModerate acceleration factorsDegradation of image qualityTagged MRCardiac phantomLong acquisition timesPhantomAccurate motion field
2014
Relative role of motion and PSF compensation in whole‐body oncologic PET‐MR imaging
Petibon Y, Huang C, Ouyang J, Reese T, Li Q, Syrkina A, Chen Y, Fakhri G. Relative role of motion and PSF compensation in whole‐body oncologic PET‐MR imaging. Medical Physics 2014, 41: 042503. PMID: 24694156, PMCID: PMC3971824, DOI: 10.1118/1.4868458.Peer-Reviewed Original ResearchConceptsPoint spread function modelRespiratory motionPoint spread functionPET-MR scannersPencil-beam navigator echoesPET-MRMeasurement of respiratory motionPSF modelRespiratory motion correctionDetector blur effectsModel respiratory motionLung-liver interfacePatient studiesLesion contrastSimultaneous PET-MRSource of image degradationWhole-body PET imagingPET reconstruction algorithmMoving lesionsPhantom experiment resultsPET eventsContrast recoveryNavigator echoesIterative reconstruction processMotion correctionMR‐based motion correction for PET imaging using wired active MR microcoils in simultaneous PET‐MR: Phantom study
Huang C, Ackerman J, Petibon Y, Brady T, Fakhri G, Ouyang J. MR‐based motion correction for PET imaging using wired active MR microcoils in simultaneous PET‐MR: Phantom study. Medical Physics 2014, 41: 041910. PMID: 24694141, PMCID: PMC3978416, DOI: 10.1118/1.4868457.Peer-Reviewed Original ResearchConceptsMotion correctionMR-based motion correctionStatic phantom dataPET quantitative accuracyPET-MRPET-MR scannersSimultaneous PET-MRHoffman phantomList-modePositron emission tomography imagingPET reconstructionBrain positron emission tomographyIterative PET reconstructionPhantom dataPhantomQuantitative accuracyIndependent noise realizationsImage contrastNoise realizationsHead motionPET dataPositron emission tomographyStatic referenceBrain PET scansMotion artifactsTowards coronary plaque imaging using simultaneous PET-MR: a simulation study
Petibon Y, Fakhri G, Nezafat R, Johnson N, Brady T, Ouyang J. Towards coronary plaque imaging using simultaneous PET-MR: a simulation study. Physics In Medicine And Biology 2014, 59: 1203-1222. PMID: 24556608, PMCID: PMC4061607, DOI: 10.1088/0031-9155/59/5/1203.Peer-Reviewed Original ResearchMeSH KeywordsComputer SimulationCoronary AngiographyCoronary StenosisHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance AngiographyModels, CardiovascularMultimodal ImagingPhantoms, ImagingPositron-Emission TomographyReproducibility of ResultsSensitivity and SpecificityConceptsSimultaneous PET-MRChannelized Hotelling observerAttenuation mapMotion correctionPET-MRFluorodeoxyglucose-positron emission tomography imagingRespiratory motion fieldsMotion correction methodCho SNRMotion correction techniqueAnthropomorphic phantomUncorrected reconstructionsRespiratory motionXCAT phantomCoronary plaque imagingMonte Carlo simulationsPET reconstructionXCATActivity distributionCardiac gatingNon-rigid registrationHotelling observerCarlo simulationsPlaque imagingPhantomMotion compensation for brain PET imaging using wireless MR active markers in simultaneous PET–MR: Phantom and non-human primate studies
Huang C, Ackerman J, Petibon Y, Normandin M, Brady T, Fakhri G, Ouyang J. Motion compensation for brain PET imaging using wireless MR active markers in simultaneous PET–MR: Phantom and non-human primate studies. NeuroImage 2014, 91: 129-137. PMID: 24418501, PMCID: PMC3965607, DOI: 10.1016/j.neuroimage.2013.12.061.Peer-Reviewed Original ResearchConceptsMotion correctionWireless markersList-mode reconstructionReconstructed PET imagesMotion correction techniqueObserver signal-to-noise ratioSimultaneous PET-MRMotion artifactsPET phantomPET contrastPET reconstructionBrain PET imagingPET imagingPhantomBrain PETPET-MRIndependent noise realizationsAccurate quantitative valuesHead motionNoise realizationsPET dataSignal-to-noise ratioStatic referenceBrain PET scansActivation markers
2013
Cardiac motion compensation and resolution modeling in simultaneous PET-MR: a cardiac lesion detection study
Petibon Y, Ouyang J, Zhu X, Huang C, Reese T, Chun S, Li Q, Fakhri G. Cardiac motion compensation and resolution modeling in simultaneous PET-MR: a cardiac lesion detection study. Physics In Medicine And Biology 2013, 58: 2085-2102. PMID: 23470288, PMCID: PMC3657754, DOI: 10.1088/0031-9155/58/7/2085.Peer-Reviewed Original ResearchConceptsContrast recoveryDetector point spread functionPartial volume effectsK-spaceMotion compensationB-spline registrationLesion-detection studiesCardiac motion compensationPET-MR scannersSimultaneous PET-MRPET contrastIterative reconstruction frameworkPoint spread functionMotion correctionPET countsNon-rigid B-spline registrationCardiac phantomPSF modelPET-MRMotion deblurringReconstruction frameworkSystem matrixCardiac PETSpread functionDefect detectionMagnetic Resonance-Based Motion Correction for Positron Emission Tomography Imaging
Ouyang J, Li Q, Fakhri G. Magnetic Resonance-Based Motion Correction for Positron Emission Tomography Imaging. Seminars In Nuclear Medicine 2013, 43: 60-67. PMID: 23178089, PMCID: PMC3508789, DOI: 10.1053/j.semnuclmed.2012.08.007.Peer-Reviewed Original ResearchConceptsMotion correctionClinical whole-body PET scannersMotion-corrected PET imagesWhole-body PET scannerPET motion correctionNonrigid image registration algorithmAcquired MR imagesRespiratory motionImage registration algorithmPET scannerSimultaneous PET/magnetic resonancePET reconstructionSimultaneous PET/MRPatient motionImage qualityIterative PET reconstructionPET/MR studiesPET/magnetic resonanceAttenuating mediaImage artifactsRegistration algorithmSpatial resolutionReconstruction algorithmPositron emission tomographyMR imaging techniques
2012
MRI-Based Nonrigid Motion Correction in Simultaneous PET/MRI
Chun Y, Reese T, Ouyang J, Guerin B, Catana C, Zhu X, Alpert N, Fakhri G. MRI-Based Nonrigid Motion Correction in Simultaneous PET/MRI. Journal Of Nuclear Medicine 2012, 53: 1284-1291. PMID: 22743250, PMCID: PMC4077320, DOI: 10.2967/jnumed.111.092353.Peer-Reviewed Original ResearchConceptsChannelized Hotelling observerMotion correctionDetection signal-to-noise ratioSignal-to-noise ratioMRI-based motion correctionRespiratory motion correctionMotion-corrected reconstructionOrdered-subsets expectation maximization algorithmNonrigid motion correctionChannelized Hotelling observer studyPET image qualityNonrigid image registration methodCoincidence dataDeformable phantomRespiratory gatingReduce radiation doseDynamic phantomImage registration methodReduced signal-to-noise ratioSimultaneous PET/MRICost of increased noiseHotelling observerPhantomAttenuation measurementsRabbit studies
2011
Nonrigid PET motion compensation in the lower abdomen using simultaneous tagged‐MRI and PET imaging
Guérin B, Cho S, Chun S, Zhu X, Alpert N, Fakhri G, Reese T, Catana C. Nonrigid PET motion compensation in the lower abdomen using simultaneous tagged‐MRI and PET imaging. Medical Physics 2011, 38: 3025-3038. PMID: 21815376, PMCID: PMC3125080, DOI: 10.1118/1.3589136.Peer-Reviewed Original ResearchConceptsPET-MRI acquisitionsMotion correctionPET motion compensationPET motion correctionRespiratory motion correctionMotion-corrected reconstructionMotion correction strategiesWhole-body PET studiesSignal-to-noise ratioPET reconstruction algorithmDeformable phantomNCAT phantomEffects of motionAttenuation mapDetected coincidencesPET-MRIGated framesBrain scannerSimulations of tumorsSignal-to-noisePhantomSusceptibility artifactsReconstruction algorithmPhase domainsNonrigid deformation