2024
F18. ROLE OF PSYCHIATRIC-ASSOCIATED SNVS IN THE EARLY ADULTHOOD: INSIGHTS FROM LONGITUDINAL NEUROIMAGING
Ito L, Ota V, Fernandes D, Martins A, Carvalho C, Zugman A, Sato J, Bressan R, Miguel E, Pan P, Salum G, Belangero S, Santoro M. F18. ROLE OF PSYCHIATRIC-ASSOCIATED SNVS IN THE EARLY ADULTHOOD: INSIGHTS FROM LONGITUDINAL NEUROIMAGING. European Neuropsychopharmacology 2024, 87: 214-215. DOI: 10.1016/j.euroneuro.2024.08.429.Peer-Reviewed Original ResearchPost-traumatic stress disorderAttention deficit/hyperactivity disorderBrain regionsBipolar disorderMental conditionBrain structuresBrazilian High-Risk Cohort StudyPrefrontal cortex regionsFrontal pole regionsHigh Risk Cohort StudyLateral orbitofrontal regionGenome-wide association studiesSignificant main effectDepressive disorderMixed-effects modelsStress disorderDeficit/hyperactivity disorderFrontal cortexOrbitofrontal regionsBiological underpinningsGenetic influencesCortex regionsLongitudinal relationshipIntracranial volumeEarly adulthood
2022
Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways
Axelrud L, Hoffmann M, Vosberg D, Santoro M, Pan P, Gadelha A, Belangero S, Miguel E, Shin J, Thapar A, Smoller J, Pausova Z, Rohde L, Keller M, Paus T, Salum G. Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways. Journal Of Child Psychology And Psychiatry 2022, 64: 408-416. PMID: 36162806, DOI: 10.1111/jcpp.13708.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderPolygenic scoresOffspring cognitionIntergenerational transmissionMultiple mediation modelEducational attainmentBehavioral traitsCognitive measuresExecutive functionGeneral intelligenceHyperactivity disorderMediation modelMultiple mediationCognitive AssessmentCognitionPsychopathologyGenetic influencesParental educationPsychotic symptomsDirect associationParental geneticsAttainmentDiscovery sampleGenetic riskFathers