2021
Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
Kim H, Lee K, Kim J, Kim M, Kim J, Lee H, Chung Y, Shin H, Kim T, Park E, Rho J, Lee S, Kim N, Lee S, Choi Y, Jeong D. Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts. Nature Communications 2021, 12: 2258. PMID: 33859201, PMCID: PMC8050258, DOI: 10.1038/s41467-021-22565-7.Peer-Reviewed Original ResearchConceptsSelenoprotein WCell-cell fusionRNA sequencing analysisProfile of receptor activationOsteoclast differentiationNuclear factor of activated T cells cytoplasmic 1Bone remodelingBone mass phenotypeOsteoclastogenesis in vitroNuclear translocation of NF-kBTranslocation of NF-kBPhysiological bone remodelingBlocks osteoporosisNuclear translocationNuclear factorOsteoclastogenic genesMechanism of actionMass phenotypeBone metabolismBone resorptionReceptor activationOsteoclast maturationCytoplasmic 1Osteoclast formationNF-kB
2008
NHE10, a novel osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival
Lee S, Kim T, Park E, Yang S, Jeong D, Choi Y, Rho J. NHE10, a novel osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival. Biochemical And Biophysical Research Communications 2008, 369: 320-326. PMID: 18269914, DOI: 10.1016/j.bbrc.2008.01.168.Peer-Reviewed Original ResearchConceptsFull-length cDNANa(+)/H(+) exchangerIsolated full-length cDNAsMembrane-spanning domainsNa(+)/H(+) exchanger familyGene expression profilesResponse to receptor activationGene candidatesOC differentiationCDNA microarrayNa+/H+ exchanger familyClonesLigand signalingFunctional roleCDNAAction of osteoblastsRegulates osteoclast differentiationGenesReceptor activationOsteoclast differentiationBone homeostasisDifferentiationBalanced actionOsteoclastsSurvival