2021
Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
Kim H, Lee K, Kim J, Kim M, Kim J, Lee H, Chung Y, Shin H, Kim T, Park E, Rho J, Lee S, Kim N, Lee S, Choi Y, Jeong D. Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts. Nature Communications 2021, 12: 2258. PMID: 33859201, PMCID: PMC8050258, DOI: 10.1038/s41467-021-22565-7.Peer-Reviewed Original ResearchConceptsSelenoprotein WCell-cell fusionRNA sequencing analysisProfile of receptor activationOsteoclast differentiationNuclear factor of activated T cells cytoplasmic 1Bone remodelingBone mass phenotypeOsteoclastogenesis in vitroNuclear translocation of NF-kBTranslocation of NF-kBPhysiological bone remodelingBlocks osteoporosisNuclear translocationNuclear factorOsteoclastogenic genesMechanism of actionMass phenotypeBone metabolismBone resorptionReceptor activationOsteoclast maturationCytoplasmic 1Osteoclast formationNF-kB
2014
Development of transgenic mouse model expressing porcine aminopeptidase N and its susceptibility to porcine epidemic diarrhea virus
Park J, Park E, Yu J, Rho J, Paudel S, Hyun B, Yang D, Shin H. Development of transgenic mouse model expressing porcine aminopeptidase N and its susceptibility to porcine epidemic diarrhea virus. Virus Research 2014, 197: 108-115. PMID: 25550073, PMCID: PMC7114392, DOI: 10.1016/j.virusres.2014.12.024.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD13 AntigensCoronavirus InfectionsDisease Models, AnimalMice, TransgenicPorcine epidemic diarrhea virusReceptors, VirusSwineConceptsSusceptible to porcine epidemic diarrhea virusPorcine epidemic diarrhea virusDiarrhea virusPorcine coronavirusPorcine APNLaboratory animal modelsPorcine aminopeptidase NPorcineAminopeptidase NCoronavirus infectionRespiratory diseaseTransgenic miceAnimal modelsCoronavirus studiesVirusPigsMiceInfectionTransgeneSusceptibility