T-Cell Death-Associated Gene 51 Is a Novel Negative Regulator of PPARγ That Inhibits PPARγ-RXRα Heterodimer Formation in Adipogenesis
Kim S, Lee N, Park E, Yun H, Ha T, Jeon H, Yu J, Choi S, Shin B, Yu J, Dal Rhee S, Choi Y, Rho J. T-Cell Death-Associated Gene 51 Is a Novel Negative Regulator of PPARγ That Inhibits PPARγ-RXRα Heterodimer Formation in Adipogenesis. Molecules And Cells 2020, 44: 1-12. PMID: 33335079, PMCID: PMC7854182, DOI: 10.14348/molcells.2020.0143.Peer-Reviewed Original ResearchConceptsLigand-independent mannerRepeat domainRetinoid X receptorBinding domainNegative regulatorHeterodimer formationEarly stage of adipogenic differentiationActivation function-2 domainPleckstrin homology-likeT-cell death-associated geneDNA-binding domainDeletion mutant analysisDeath-associated genesStage of adipogenic differentiationLigand-binding domainMutant analysisGlutamine repeatsCell fateTranscriptional activityPeroxisome proliferator-activated receptor gTDAG51 expressionAdipocyte differentiationHeterodimer complexTDAG51Adipogenic cell fate