2021
Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
Kim H, Lee K, Kim J, Kim M, Kim J, Lee H, Chung Y, Shin H, Kim T, Park E, Rho J, Lee S, Kim N, Lee S, Choi Y, Jeong D. Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts. Nature Communications 2021, 12: 2258. PMID: 33859201, PMCID: PMC8050258, DOI: 10.1038/s41467-021-22565-7.Peer-Reviewed Original ResearchConceptsSelenoprotein WCell-cell fusionRNA sequencing analysisProfile of receptor activationOsteoclast differentiationNuclear factor of activated T cells cytoplasmic 1Bone remodelingBone mass phenotypeOsteoclastogenesis in vitroNuclear translocation of NF-kBTranslocation of NF-kBPhysiological bone remodelingBlocks osteoporosisNuclear translocationNuclear factorOsteoclastogenic genesMechanism of actionMass phenotypeBone metabolismBone resorptionReceptor activationOsteoclast maturationCytoplasmic 1Osteoclast formationNF-kB
2010
ATP6v0d2 deficiency increases bone mass, but does not influence ovariectomy-induced bone loss
Kim T, Ha H, Kim N, Park E, Rho J, Kim E, Lorenzo J, Choi Y, Lee S. ATP6v0d2 deficiency increases bone mass, but does not influence ovariectomy-induced bone loss. Biochemical And Biophysical Research Communications 2010, 403: 73-78. PMID: 21040703, PMCID: PMC3026595, DOI: 10.1016/j.bbrc.2010.10.117.Peer-Reviewed Original ResearchConceptsColony forming unit-granulocyte/macrophageBone lossActions of bone-forming osteoblastsOsteoclast maturationOvariectomy (OVX)-induced bone lossOVX-induced bone lossBone homeostasisOVX-induced increaseIncreased bone resorptionBone marrow cellsOsteoclast formation in vitroExcessive bone lossPathological conditionsNormal developmentBone-forming osteoblastsBone-resorbing osteoclastsControl of bone homeostasisMarrow cellsBone massProtect miceBone resorptionFormation in vitroOsteoclast differentiationOsteoclast precursorsAtp6v0d2