2024
Trends in Age, Sex, and Racial Differences in the Incidence of Infective Endocarditis in Florida and New York
Anuforo A, Aneni E, Akintoye E, Anikpezie N, Patel S, Soipe A, Olojakpoke E, Burke D, Latorre J, Khandelwal P, Chaturvedi S, Ovbiagele B, Otite F. Trends in Age, Sex, and Racial Differences in the Incidence of Infective Endocarditis in Florida and New York. Circulation 2024, 149: 1391-1393. PMID: 38648273, DOI: 10.1161/circulationaha.123.066921.Peer-Reviewed Original Research
2023
Impact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation
Akintoye E, Saijo Y, Braghieri L, Badwan O, Patel H, Dabbagh M, El Dahdah J, Jellis C, Desai M, Rodriguez L, Grimm R, Griffin B, Popović Z. Impact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation. Journal Of The American College Of Cardiology 2023, 81: 1474-1487. PMID: 37045517, DOI: 10.1016/j.jacc.2023.02.037.Peer-Reviewed Original ResearchConceptsSmaller LV volumesAdverse eventsAortic regurgitationBody surface areaOlder patientsYounger patientsLV volumesImpact of ageLV remodelingSerial evaluationLV end-systolic volumeLV end-diastolic volumeSevere aortic regurgitationChronic aortic regurgitationLeft ventricular remodelingEnd-diastolic volumeEnd-systolic volumeLower LV volumesAdult patientsConsecutive patientsMain endpointVentricular dimensionsVentricular remodelingCurrent guidelinesPatients
2022
Clinical outcomes and 30-day readmissions associated with high-output heart failure
Uddin M, Mir T, Briasoulis A, Akintoye E, Adegbala O, Shafi I, Qureshi W, Afonso L. Clinical outcomes and 30-day readmissions associated with high-output heart failure. Hellenic Journal Of Cardiology 2022, 69: 24-30. PMID: 36273803, DOI: 10.1016/j.hjc.2022.10.004.Peer-Reviewed Original ResearchConceptsHigh-output heart failureNational Readmission DatabaseHeart failureMyelodysplastic syndromeHealthcare costsUtilization Project National Readmission DatabaseLow systemic vascular resistanceReduced ejection fractionSystemic vascular resistanceHigh cardiac outputQuality's Healthcare CostSickle cell diseaseHospital mortalityNoncardiovascular disordersUnderdiagnosed typeCardiovascular complicationsMorbid obesityVascular resistanceHematological complicationsReadmission ratesEjection fractionPulmonary diseaseClinical outcomesCardiac outputDiagnostic codesTrends and Outcomes of Patients With Amyloid Cardiomyopathy Listed for Heart Transplantation
Akintoye E, Salih M, Aje K, Alvarez P, Sellke F, Briasoulis A, Dorbala S. Trends and Outcomes of Patients With Amyloid Cardiomyopathy Listed for Heart Transplantation. Canadian Journal Of Cardiology 2022, 38: 1263-1270. PMID: 35525397, DOI: 10.1016/j.cjca.2022.04.023.Peer-Reviewed Original ResearchConceptsHeart transplantGraft survivalAmyloid cardiomyopathyWaitlist mortalityHeart transplantationRisk factorsSingle-organ heart transplantsStudy periodHeart transplant waitlistUnderwent heart transplantWorse graft survivalGraft survival ratesOutcomes of patientsPropensity-matched cohortOrgan Sharing databaseHigher waitlist mortalityNumber of patientsNumber of transplantsAmyloid recurrenceAdult patientsGraft failureRenal failureIndependent predictorsSharing databaseUnited NetworkClinical, functional and prognostic implications of severe atrial dilation in secondary mitral regurgitation
Layoun H, Mentias A, Akintoye E, Matta M, Kanaan C, Daou R, Ramchand J, Burns D, Gillinov A, Bhattacharya S, Puri R, Collier P, Griffin B, Kapadia S, Harb S. Clinical, functional and prognostic implications of severe atrial dilation in secondary mitral regurgitation. Open Heart 2022, 9: e001996. PMID: 35383126, PMCID: PMC8984044, DOI: 10.1136/openhrt-2022-001996.Peer-Reviewed Original ResearchConceptsSecondary mitral regurgitationAtrial dilationMitral regurgitationPrognostic implicationsSevere left atrial dilationSevere secondary mitral regurgitationLA reservoir strainLeft atrial dilationLeft ventricle dysfunctionPoor prognostic indicatorMV interventionVentricle dysfunctionMore diabetesAdult patientsTransthoracic echocardiographyEjection fractionIndependent predictorsAtrial fibrillationReservoir strainWorse prognosisPrognostic indicatorMR severityBetter outcomesFunctional alterationsPatientsOutcomes of diabetic patients with end‐stage heart failure listed for heart transplantation: A propensity‐matched analysis
Akintoye E, Alvarez P, Salih M, Sellke F, Briasoulis A. Outcomes of diabetic patients with end‐stage heart failure listed for heart transplantation: A propensity‐matched analysis. Clinical Transplantation 2022, 36: e14590. PMID: 35018661, DOI: 10.1111/ctr.14590.Peer-Reviewed Original ResearchConceptsDiabetic patientsWaitlist mortalityHeart transplantPost-transplant graft survivalEnd-stage heart failurePropensity-matched cohortHeart failure patientsGraft survivalAdult patientsFailure patientsGraft failureHeart failureUnited NetworkRisk factorsOrgan SharingPatientsStudy periodTransplantMortalityFailureCohortWaitlist
2021
Changing Demographics, Temporal Trends in Waitlist, and Posttransplant Outcomes After Heart Transplantation in the United States: Analysis of the UNOS Database 1991–2019
Akintoye E, Alvarez P, Shin D, Egbe A, Panos A, Sellke F, Briasoulis A. Changing Demographics, Temporal Trends in Waitlist, and Posttransplant Outcomes After Heart Transplantation in the United States: Analysis of the UNOS Database 1991–2019. Circulation Heart Failure 2021, 14: e008764. PMID: 34689572, DOI: 10.1161/circheartfailure.121.008764.Peer-Reviewed Original ResearchConceptsHeart transplantationPosttransplant outcomesPatient characteristicsHigh-risk comorbiditiesCharacteristics of patientsShort-term survivalRisk comorbiditiesHospital strokeWaitlist mortalityRenal failureUnited NetworkTransplant volumeEra 1Organ SharingPatientsTransplantationWaitlistEra 4Study periodTime pointsSignificant decreaseTemporal trendsOutcomesSignificant changesUnited StatesLongitudinal trends and outcomes of adult heart transplantation in the U.S.
Akintoye E, Asleh R, Alvarez P, Briasoulis A. Longitudinal trends and outcomes of adult heart transplantation in the U.S. European Journal Of Internal Medicine 2021, 86: 115-117. PMID: 33495082, DOI: 10.1016/j.ejim.2021.01.001.Peer-Reviewed Original Research
2020
Characteristics and Outcomes of Patients Undergoing Combined Organ Transplantation (from the United Network for Organ Sharing)
Briasoulis A, Akintoye E, Kuno T, Alvarez P. Characteristics and Outcomes of Patients Undergoing Combined Organ Transplantation (from the United Network for Organ Sharing). The American Journal Of Cardiology 2020, 129: 42-45. PMID: 32540168, DOI: 10.1016/j.amjcard.2020.05.034.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack or African AmericanCardiomyopathy, DilatedCardiomyopathy, RestrictiveFemaleGraft RejectionHeart Defects, CongenitalHeart FailureHeart TransplantationHeart-Lung TransplantationHispanic or LatinoHumansKidney DiseasesKidney TransplantationLiver DiseasesLiver TransplantationLung DiseasesMaleMiddle AgedMortalityProportional Hazards ModelsRegistriesReoperationSurvival RateWhite PeopleConceptsHeart-liver transplantPrimary heart transplantationLong-term survivalHeart transplantationOrgan transplantsStage D heart failureD heart failureOutcomes of patientsOrgan Sharing registryLong-term outcomesCongenital heart diseaseAdult patientsMedian survivalHeart failureTransplantation ratesUnited NetworkList timeHeart diseaseOperative characteristicsOrgan transplantationSurvival analysisPatientsTransplantInverse probabilityStudy periodTemporal trends and outcomes of patients waiting on left ventricular assist devices and inotropes for heart transplantation
Briasoulis A, Adegbala O, Akintoye E, Alvarez P. Temporal trends and outcomes of patients waiting on left ventricular assist devices and inotropes for heart transplantation. Clinical Transplantation 2020, 34: e13857. PMID: 32167606, DOI: 10.1111/ctr.13857.Peer-Reviewed Original ResearchConceptsLeft ventricular assist deviceRight ventricular assist deviceVentricular assist deviceOutcomes of patientsTime of listingTime of transplantationHeart transplantationAssist deviceOrgan Sharing registryTerms of survivalStatus 1AInotropic therapyLVAD recipientsUnited NetworkWorse outcomesInotropesHigh riskWaiting listPatientsTransplantationLower ratesOutcomesTemporal trendsConfoundersRegistryRural–Urban Disparities in Intracerebral Hemorrhage Mortality in the USA: Preliminary Findings from the National Inpatient Sample
Otite F, Akano E, Akintoye E, Khandelwal P, Malik A, Chaturvedi S, Rosand J. Rural–Urban Disparities in Intracerebral Hemorrhage Mortality in the USA: Preliminary Findings from the National Inpatient Sample. Neurocritical Care 2020, 32: 715-724. PMID: 32232726, PMCID: PMC7223184, DOI: 10.1007/s12028-020-00950-2.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAphasiaCerebral HemorrhageComorbidityCraniotomyDeglutition DisordersFemaleHealthcare DisparitiesHospital Bed CapacityHospital MortalityHospitals, RuralHospitals, UrbanHumansHydrocephalusMaleMiddle AgedRespiration, ArtificialRisk FactorsUnited StatesYoung AdultConceptsNational Inpatient SampleSex-adjusted mortalityUrban hospitalRural hospitalsICH patientsInpatient SampleJoinpoint regressionIntracerebral hemorrhage mortalityMultivariable-adjusted modelsOdds of mortalityIntracerebral hemorrhage patientsCases of ICHHospital deathHospital mortalityMultivariable adjustmentUrban patientsRural patientsStroke careHemorrhage patientsMedicare insuranceRural-urban disparitiesPatientsResultsFrom 2004HospitalMortality gap
2019
Left Ventricular Systolic Dysfunction and Cardiovascular Outcomes in Tetralogy of Fallot: Systematic Review and Meta-analysis
Egbe A, Adigun R, Anand V, West C, Montori V, Murad M, Akintoye E, Osman K, Connolly H. Left Ventricular Systolic Dysfunction and Cardiovascular Outcomes in Tetralogy of Fallot: Systematic Review and Meta-analysis. Canadian Journal Of Cardiology 2019, 35: 1784-1790. PMID: 31732195, DOI: 10.1016/j.cjca.2019.07.634.Peer-Reviewed Original ResearchConceptsCardiovascular adverse eventsLV ejection fractionLeft ventricular systolic dysfunctionLV systolic dysfunctionVentricular systolic dysfunctionSystolic dysfunctionHazard ratioLV systolic functionSudden cardiac deathNew treatment optionsClinical risk stratificationConfidence intervalsTetralogy of FallotVentricular tachycardia eventsRandom-effects modelCardiovascular outcomesAdverse eventsSystolic functionCardiac deathEjection fractionIndependent predictorsRisk stratificationPrognostic implicationsTreatment optionsTachycardia eventsClinical and economic burden of heparin-induced thrombocytopenia in hospitalized patients undergoing percutaneous peripheral arterial interventions
Subahi A, Osman M, Adegbala O, Abubakar H, Kheiri B, Yassin A, Khalid M, Akintoye E, Eljack A, Osman K, Alkhouli M. Clinical and economic burden of heparin-induced thrombocytopenia in hospitalized patients undergoing percutaneous peripheral arterial interventions. Vascular 2019, 28: 81-86. PMID: 31382836, DOI: 10.1177/1708538119868615.Peer-Reviewed Original ResearchConceptsVenous thrombosis/pulmonary embolismAcute kidney injuryKidney injuryIschemic strokePulmonary embolismHigh riskDeep venous thrombosis/pulmonary embolismPercutaneous peripheral arterial interventionsICD-9-CM codesHospital mortality differenceProlonged hospital stayHospital-level characteristicsPeripheral arterial interventionsNational Inpatient SampleHospital outcomesHospital stayIntervention patientsAbsence of heparinBaseline characteristicsHome dischargeLonger hospitalizationArterial interventionsHospitalized patientsInpatient SampleThrombocytopeniaTrends in the Incidence of In-Hospital Mortality, Cardiogenic Shock, and Utilization of Mechanical Circulatory Support Devices in Myocarditis (Analysis of National Inpatient Sample Data, 2005–2014)
Pahuja M, Adegbala O, Mishra T, Akintoye E, Chehab O, Mony S, Singh M, Ando T, Abubaker H, Yassin A, Subahi A, Shokr M, Ranka S, Briasoulis A, Kapur N, Burkhoff D, Afonso L. Trends in the Incidence of In-Hospital Mortality, Cardiogenic Shock, and Utilization of Mechanical Circulatory Support Devices in Myocarditis (Analysis of National Inpatient Sample Data, 2005–2014). Journal Of Cardiac Failure 2019, 25: 457-467. PMID: 31035007, DOI: 10.1016/j.cardfail.2019.04.012.Peer-Reviewed Original ResearchConceptsIncidence of CSCardiogenic shockMechanical circulatory supportHospital mortalityMCS devicesPercutaneous ventricular assist deviceNational Inpatient Sample databaseMechanical circulatory support devicesIncidence of myocarditisPercutaneous cardiopulmonary supportCases of myocarditisIn-Hospital MortalityExtracorporeal membrane oxygenationCirculatory support devicesVentricular assist deviceTandem HeartHemodynamic instabilityMultiple comorbiditiesCardiopulmonary supportEndomyocardial biopsyMembrane oxygenationTotal admissionsCirculatory supportPatient mortalityPoor prognosisCardiac Implantable Electronic Devices in Adults with Tetralogy of Fallot
Egbe A, Vallabhajosyula S, Akintoye E, Deshmukh A. Cardiac Implantable Electronic Devices in Adults with Tetralogy of Fallot. The American Journal Of Cardiology 2019, 123: 1999-2001. PMID: 30961908, DOI: 10.1016/j.amjcard.2019.03.010.Peer-Reviewed Original ResearchConceptsCardiac implantable electronic devicesImplantable electronic devicesNationwide/National Inpatient SampleInflation-adjusted hospitalization costsNational Inpatient Sample databaseCharlson Comorbidity IndexMean hospital lengthPopulation-based studyNational Inpatient SampleSudden cardiac deathTetralogy of FallotTime of implantationComorbidity indexHospital lengthHospital mortalityCardiac deathTOF repairRepaired tetralogyRetrospective reviewHospitalization costsCIED implantationInpatient SampleTOF populationAdmissionObserved temporal increaseTrends in utilization, mortality, major complications, and cost after total artificial heart implantation in the United States (2009-2015)
Briasoulis A, Akintoye E, Mohsen A, Inampudi C, Briasouli A, Asleh R, Alvarez P. Trends in utilization, mortality, major complications, and cost after total artificial heart implantation in the United States (2009-2015). Hellenic Journal Of Cardiology 2019, 61: 407-412. PMID: 30790715, DOI: 10.1016/j.hjc.2019.02.002.Peer-Reviewed Original ResearchConceptsLength of stayTotal artificial heartHospital mortalityHeart transplantationTAH implantationMajor complicationsLeft ventricular assist device implantationVentricular assist device implantationTotal artificial heart implantationComplex congenital heart diseaseStudy periodAcute kidney injuryAssist device implantationSame hospital staySevere biventricular failureDisposition of patientsNational Inpatient SampleTime of dischargeContinuous-flow LVADCost of hospitalizationArtificial heart implantationCongenital heart diseaseHospital complicationsMajor bleedingBiventricular failureTrends and Outcomes of Infective Endocarditis in Adults With Tetralogy of Fallot: A Review of the National Inpatient Sample Database
Egbe A, Vallabhajosyula S, Akintoye E, Connolly H. Trends and Outcomes of Infective Endocarditis in Adults With Tetralogy of Fallot: A Review of the National Inpatient Sample Database. Canadian Journal Of Cardiology 2019, 35: 721-726. PMID: 31151707, DOI: 10.1016/j.cjca.2019.02.006.Peer-Reviewed Original ResearchConceptsHealth care resource utilizationTetralogy of FallotProsthetic valve implantationNational Inpatient SampleCongenital heart diseaseHospital mortalityValve implantationInfective endocarditisHeart diseaseRisk factorsTOF patientsInflation-adjusted hospitalization costsNational Inpatient Sample databaseCyanotic congenital heart diseaseIncidence of endocarditisLength of stayPacemaker/defibrillatorLow socioeconomic classPopulation-based riskHospital dischargeSecondary outcomesPrimary outcomeHospitalization costsBlack raceInpatient SampleImpact of atrial fibrillation on patients hospitalized for acute myocarditis: Insights from a nationally‐representative United States cohort
Subahi A, Akintoye E, Yassin A, Abubakar H, Adegbala O, Mishra T, Abdelrahman M, Shokr M, Afonso L. Impact of atrial fibrillation on patients hospitalized for acute myocarditis: Insights from a nationally‐representative United States cohort. Clinical Cardiology 2019, 42: 26-31. PMID: 30284301, PMCID: PMC6436524, DOI: 10.1002/clc.23088.Peer-Reviewed Original ResearchConceptsAtrial fibrillationHospital mortalityHospital outcomesAcute myocarditisICD-9-CM diagnostic codesNon-routine hospital dischargeImpact of AFPropensity score-matched control groupAcute myocarditis patientsAcute kidney injuryUnited States cohortNational Inpatient SampleCardiac tamponadeCardiogenic shockCause mortalityKidney injuryMyocarditis patientsAM patientsHospital dischargeAF groupInpatient SamplePrimary diagnosisDiagnostic codesHigh riskGeneral population
2018
Clinical Impact of Diabetes Mellitus on Short-Term Outcomes andIn-Hospital Mortality of Cardiac Mechanical Support with Left Ventricular Assist Device (LVAD): A Retrospective Study from a National Database
Yassin A, Subahi A, Adegbala O, Abubakar H, Akintoye E, Ahmed A, Ismail A, Elhag A, Kambal A, Alade A, Shokr M, Weinberger J, Levine D, Afonso L. Clinical Impact of Diabetes Mellitus on Short-Term Outcomes andIn-Hospital Mortality of Cardiac Mechanical Support with Left Ventricular Assist Device (LVAD): A Retrospective Study from a National Database. Cardiovascular Revascularization Medicine 2018, 20: 883-886. PMID: 30578171, DOI: 10.1016/j.carrev.2018.12.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedDatabases, FactualDiabetes MellitusFemaleHeart FailureHeart-Assist DevicesHospital MortalityHumansMaleMiddle AgedProsthesis DesignProsthesis ImplantationRecovery of FunctionRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesVentricular Dysfunction, LeftVentricular Function, LeftConceptsLeft ventricular assist deviceCardiac mechanical supportDiabetes mellitusCost of hospitalizationCardiac supportVentricular assist deviceHospital mortalityDiabetic patientsHeart failureClinical impactMultivariable logistic regression model analysisAssist deviceStage D heart failureAdvanced congestive heart failureNational Inpatient Sample databasePost-LVAD complicationsShort-term complicationsCongestive heart failureLogistic regression model analysisHospital-level characteristicsImpact of diabetesRegression model analysisInpatient mortalityLVAD implantationSecondary outcomesVenous congestion and pulmonary vascular function in Fontan circulation: Implications for prognosis and treatment
Egbe A, Reddy Y, Khan A, Al-Otaibi M, Akintoye E, Obokata M, Borlaug B. Venous congestion and pulmonary vascular function in Fontan circulation: Implications for prognosis and treatment. International Journal Of Cardiology 2018, 271: 312-316. PMID: 30223363, PMCID: PMC6146405, DOI: 10.1016/j.ijcard.2018.05.039.Peer-Reviewed Original ResearchConceptsPulmonary vascular resistance indexCentral venous pressureSystemic venous congestionPulmonary vascular functionFontan patientsVenous congestionFontan circulationVascular functionElevated pulmonary vascular resistance indexAdult Fontan patientsVascular resistance indexPulmonary blood flowSub-pulmonary ventricleCongenital heart diseaseLow-level elevationsPulmonary vascular structureFontan groupFontan populationAntiplatelet therapyCause mortalityCardiac catheterizationComposite endpointVenous pressureMulticenter studyAdverse outcomes