2017
Measurement of PD-1, TIM-3 and LAG-3 protein in non-small cell lung carcinomas (NSCLCs) with acquired resistance to PD-1 axis blockers.
Datar I, Mani N, Henick B, Wurtz A, Kaftan E, Herbst R, Rimm D, Gettinger S, Politi K, Schalper K. Measurement of PD-1, TIM-3 and LAG-3 protein in non-small cell lung carcinomas (NSCLCs) with acquired resistance to PD-1 axis blockers. Journal Of Clinical Oncology 2017, 35: e14611-e14611. DOI: 10.1200/jco.2017.35.15_suppl.e14611.Peer-Reviewed Original ResearchNon-small cell lung carcinomaTim-3PD-1LAG-3T cellsInhibitory receptorsAdvanced non-small cell lung carcinomaPD-1 axis blockadeHigh TIM-3Immune suppressive pathwaysImmune inhibitory receptorsCell lung carcinomaMembranous staining patternPre-treatment samplesWhole tissue sectionsWhole tumor areaClinical responseMost patientsAxis blockadeLow levelsLung carcinomaT lymphocytesMultiplex immunofluorescenceHigh levelsSuppressive pathwaysP3.02c-070 Combination Immunotherapy with MEK Inhibitor for Treatment of Kras-Mutant Lung Cancer in Animal Model Topic: IT Biomarkers
Lee J, Zhang Y, Choi J, Sharma R, Park H, Kaftan E, Papadimitrakopoulou V, Herbst R, Koo J. P3.02c-070 Combination Immunotherapy with MEK Inhibitor for Treatment of Kras-Mutant Lung Cancer in Animal Model Topic: IT Biomarkers. Journal Of Thoracic Oncology 2017, 12: s1319. DOI: 10.1016/j.jtho.2016.11.1865.Peer-Reviewed Original Research
2016
Objective measurement and significance of PD-L1, B7-H3, B7-H4 and TILs in small cell lung cancer (SCLC).
Schalper K, Carvajal-Hausdorf D, McLaughlin J, Altan M, Chiang A, Velcheti V, Kaftan E, Zhang J, Lu L, Rimm D, Han B, Lu H, Zhao H, Herbst R. Objective measurement and significance of PD-L1, B7-H3, B7-H4 and TILs in small cell lung cancer (SCLC). Journal Of Clinical Oncology 2016, 34: 8566-8566. DOI: 10.1200/jco.2016.34.15_suppl.8566.Peer-Reviewed Original Research
2010
Purinergic receptor-mediated morphological changes in microglia are transient and independent from inflammatory cytokine release.
McIlvain HB, Ma L, Ludwig B, Manners MT, Martone RL, Dunlop J, Kaftan EJ, Kennedy JD, Whiteside GT. Purinergic receptor-mediated morphological changes in microglia are transient and independent from inflammatory cytokine release. European Journal Of Pharmacology 2010, 643: 202-10. PMID: 20621081, DOI: 10.1016/j.ejphar.2010.06.046.Peer-Reviewed Original ResearchDevelopment of a FLIPR assay for the simultaneous identification of MrgD agonists and antagonists from a single screen.
Ajit SK, Pausch MH, Kennedy JD, Kaftan EJ. Development of a FLIPR assay for the simultaneous identification of MrgD agonists and antagonists from a single screen. Journal Of Biomedicine & Biotechnology 2010, 2010 PMID: 20936132, PMCID: PMC2947157, DOI: 10.1155/2010/326020.Peer-Reviewed Original Research
1997
Inositol 1,4,5-Trisphosphate (InsP3) and Calcium Interact to Increase the Dynamic Range of InsP3 Receptor-dependent Calcium Signaling
Kaftan E, Ehrlich B, Watras J. Inositol 1,4,5-Trisphosphate (InsP3) and Calcium Interact to Increase the Dynamic Range of InsP3 Receptor-dependent Calcium Signaling. The Journal Of General Physiology 1997, 110: 529-538. PMID: 9348325, PMCID: PMC2229389, DOI: 10.1085/jgp.110.5.529.Peer-Reviewed Original Research
1990
A mitochondrial protein fraction catalyzing transport of the K+ analog T1+.
Diwan JJ, Paliwal R, Kaftan E, Bawa R. A mitochondrial protein fraction catalyzing transport of the K+ analog T1+. FEBS Letters 1990, 273: 215-8. PMID: 1699808.Peer-Reviewed Original Research
Others
- Bowlby, M. R. and Kaftan, E.J. (2009) Sodium channel blockers for the treatment of chronic pain. In Structure, Function and Modulation of Neuronal Voltage-gated Ion Channels. Valentin Gribkoff and Leonard Kaczmarek , Editors.Peer-Reviewed Original Research
- Diwan, J.J., Haley, T., Kaftan, E., Joshi, S., and Sanadi, D. (1988) Isolation of a 53kDa protein from mitochondria which may have a role mediating K+ transport. EBEC Short Reports 5: 207.Peer-Reviewed Original Research
- Diwan, J.J., Paliwal, R., Kaftan, E., Costa, G., Joshi, S. (1991) A monovalent cation transport catalyst from rat liver mitochondria. Trends in Bioenergetics and Biomembranes 1:165-170.Peer-Reviewed Original Research