2024
Brain-phenotype predictions of language and executive function can survive across diverse real-world data: Dataset shifts in developmental populations
Adkinson B, Rosenblatt M, Dadashkarimi J, Tejavibulya L, Jiang R, Noble S, Scheinost D. Brain-phenotype predictions of language and executive function can survive across diverse real-world data: Dataset shifts in developmental populations. Developmental Cognitive Neuroscience 2024, 70: 101464. PMID: 39447452, PMCID: PMC11538622, DOI: 10.1016/j.dcn.2024.101464.Peer-Reviewed Original ResearchBrain-phenotype associationsConnectome-based predictive modelingBrain-behavior associationsPrediction of languagePhiladelphia Neurodevelopmental CohortHealthy Brain NetworkClinical symptom burdenFMRI taskHuman Connectome ProjectExecutive functionBehavioral measuresDevelopmental populationsNeurodevelopmental CohortBrain networksDevelopmental sampleConnectome ProjectResearch settingsGeneralizabilitySymptom burdenExternal validationFMRIClinical settingAssociationEthnic minority representationTask
2023
Transdiagnostic Connectome-Based Prediction of Craving
Garrison K, Sinha R, Potenza M, Gao S, Liang Q, Lacadie C, Scheinost D. Transdiagnostic Connectome-Based Prediction of Craving. American Journal Of Psychiatry 2023, 180: 445-453. PMID: 36987598, DOI: 10.1176/appi.ajp.21121207.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingImagery conditionFunctional connectomeSelf-reported cravingStudy of motivationDefault mode networkFunctional connectivity dataIndependent samplesKey phenomenological featuresNeural signaturesTransdiagnostic sampleTransdiagnostic perspectiveMode networkMotivated behaviorCentral constructAddictive disordersHuman behaviorConnectivity dataPhenomenological featuresStrongest predictorCravingTaskSubstance use-related disordersConnectomeIndividuals
2022
A generalizable connectome-based marker of in-scan sustained attention in neurodiverse youth
Horien C, Greene A, Shen X, Fortes D, Brennan-Wydra E, Banarjee C, Foster R, Donthireddy V, Butler M, Powell K, Vernetti A, Mandino F, O'Connor D, Lake E, McPartland J, Volkmar F, Chun M, Chawarska K, Rosenberg M, Scheinost D, Constable R. A generalizable connectome-based marker of in-scan sustained attention in neurodiverse youth. Cerebral Cortex 2022, 33: 6320-6334. PMID: 36573438, PMCID: PMC10183743, DOI: 10.1093/cercor/bhac506.Peer-Reviewed Original ResearchConceptsAttention taskAttentional stateConnectome-based predictive modelingNeurodiverse conditionsSustained attention taskAttention network modelSample of youthNeurotypical participantsSustained attentionBrain correlatesNeurobiological correlatesAttention networkIndividual participantsSeparate samplesYouthParticipantsHead motionTaskCorrelatesAttentionAutismConfoundsNetwork modelGeneralizesHealthcare settings
2019
Cluster failure or power failure? Evaluating sensitivity in cluster-level inference
Noble S, Scheinost D, Constable RT. Cluster failure or power failure? Evaluating sensitivity in cluster-level inference. NeuroImage 2019, 209: 116468. PMID: 31852625, PMCID: PMC8061745, DOI: 10.1016/j.neuroimage.2019.116468.Peer-Reviewed Original ResearchIndividualized functional networks reconfigure with cognitive state
Salehi M, Karbasi A, Barron DS, Scheinost D, Constable RT. Individualized functional networks reconfigure with cognitive state. NeuroImage 2019, 206: 116233. PMID: 31574322, PMCID: PMC7216521, DOI: 10.1016/j.neuroimage.2019.116233.Peer-Reviewed Original ResearchConceptsCognitive stateFunctional networksMultiple cognitive statesFunctional network organizationFunctional organizationBrain functional networksTask demandsFMRI dataSimilar tasksParcellation approachHuman brainNetwork organizationExtensive evidenceMultiple subjectsBrainNetwork membershipTaskOrganizationSubjectsParcellationSuch reconfigurationMeasuresMembershipFindingsSuch definitionsCombining multiple connectomes improves predictive modeling of phenotypic measures
Gao S, Greene AS, Constable RT, Scheinost D. Combining multiple connectomes improves predictive modeling of phenotypic measures. NeuroImage 2019, 201: 116038. PMID: 31336188, PMCID: PMC6765422, DOI: 10.1016/j.neuroimage.2019.116038.Peer-Reviewed Original ResearchConceptsMultiple connectomesLarge open-source datasetOpen-source datasetNovel prediction frameworkPredictive modelingSingle predictive modelPredictive modelArt algorithmsPrediction frameworkMultiple tasksPredictive model approachPrincipled waySpecific algorithmsFunctional connectivity matricesConnectivity matrixDifferent tasksPrediction performanceConnectome-based predictive modelingHuman Connectome ProjectTaskSuperior performanceAlgorithmComplementary informationNaïve extensionsConnectome Project
2018
Task-induced brain state manipulation improves prediction of individual traits
Greene AS, Gao S, Scheinost D, Constable RT. Task-induced brain state manipulation improves prediction of individual traits. Nature Communications 2018, 9: 2807. PMID: 30022026, PMCID: PMC6052101, DOI: 10.1038/s41467-018-04920-3.Peer-Reviewed Original ResearchConceptsBrain statesIndividual differencesBrain-behavior relationshipsFluid intelligence scoresTask-based functional connectivity analysisResting-state fMRI dataBrain functional organizationFunctional connectivity analysisCognitive tasksFluid intelligenceIntelligence scoresFunctional connectivityFMRI dataConnectivity analysisHuman behaviorIndividual traitsTaskCertain tasksFunctional organizationOutperform modelsSuch relationshipsCognitionState manipulationIntelligenceVariance
2017
Can brain state be manipulated to emphasize individual differences in functional connectivity?
Finn ES, Scheinost D, Finn DM, Shen X, Papademetris X, Constable RT. Can brain state be manipulated to emphasize individual differences in functional connectivity? NeuroImage 2017, 160: 140-151. PMID: 28373122, PMCID: PMC8808247, DOI: 10.1016/j.neuroimage.2017.03.064.Peer-Reviewed Original ResearchConceptsIndividual differencesFunctional connectivityBrain statesIndividual differences researchBrain functional organizationHuman Connectome ProjectDifferences researchBrain activityConnectome ProjectSubject variabilityNetworks of interestBehavioral phenotypesCertain tasksFunctional organizationDefault stateNeutral backdropOutline questionsFuture studiesConnectivityTaskCharacterizing Attention with Predictive Network Models
Rosenberg MD, Finn ES, Scheinost D, Constable RT, Chun MM. Characterizing Attention with Predictive Network Models. Trends In Cognitive Sciences 2017, 21: 290-302. PMID: 28238605, PMCID: PMC5366090, DOI: 10.1016/j.tics.2017.01.011.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderAttentional abilitiesLarge-scale brain networksLaboratory-based tasksDeficit hyperactivity disorderExplicit taskCognitive abilitiesHyperactivity disorderBrain networksBrain computationCognitive functionFunctional connectivityFunctional architectureTaskClinical dysfunctionEmpirical evidenceAttentionPredictive network modelsNeuromarkersNetwork modelAbilityRecent workNetwork propertiesDisordersPeople