2024
Brain correlates and functional connectivity linking stress, autonomic dysregulation, and alcohol motivation
Seo D, Martins J, Sinha R. Brain correlates and functional connectivity linking stress, autonomic dysregulation, and alcohol motivation. Neurobiology Of Stress 2024, 31: 100645. PMID: 38933283, PMCID: PMC11201348, DOI: 10.1016/j.ynstr.2024.100645.Peer-Reviewed Original ResearchAutonomic nervous system disruptionAlcohol use disorderFunctional magnetic resonance imagingHigh-risk drinkingSocial drinkersFunctional connectivityLow-risk drinkingAlcohol motivationAutonomic arousalDevelopment of alcohol use disordersNeural correlates of stressNon-dependent social drinkersWhole-brain correlation analysesResponse to stress exposureAlcohol taste testFrontal-striatal regionsStress-induced cravingVentromedial prefrontal cortexBehaviors associated with stressAnterior cingulate cortexDecreased functional connectivityExposure to stressAutonomic nervous systemAlcohol intakeHazardous alcohol useNeural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences
Radoman M, Fogelman N, Lacadie C, Seo D, Sinha R. Neural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences. American Journal Of Psychiatry 2024, 181: 412-422. PMID: 38706332, PMCID: PMC11117176, DOI: 10.1176/appi.ajp.20230849.Peer-Reviewed Original ResearchConceptsAlcohol use disorderPercentage of heavy drinking daysNeural correlates of stressCue-induced cravingHeavy drinking daysAlcohol cravingSex differencesCorrelates of stressDrinking daysAlcohol cue-induced cravingCue-induced alcohol cravingBed nucleus of the stria terminalisSubgenual anterior cingulate cortexAssessment of alcohol cravingHeavy drinkingAlcohol cue reactivityAssociated with poor treatment outcomesCue-induced responsesNeutral cue exposureAssociated with hypoactivationTreatment-seeking adultsHeavy drinking outcomesEvidence of sex differencesVoxel-based regression analysisAnterior cingulate cortex
2018
Hyperinsulinemia Invokes Greater Brain Perfusion in Reward and Motivation Regions in Obesity
GROSKREUTZ D, SINHA R, LACADIE C, LAM W, HAMZA M, SCHMIDT C, SEO D, HWANG J, BELFORT-DEAGUIAR R, LEVENTHAL J, ROSENBERG S, PARIKH L, CONSTABLE T, SHERWIN R, JASTREBOFF A. Hyperinsulinemia Invokes Greater Brain Perfusion in Reward and Motivation Regions in Obesity. Diabetes 2018, 67 DOI: 10.2337/db18-365-or.Peer-Reviewed Original ResearchCerebral blood flowElevated insulin levelsInsulin levelsFunctional magnetic resonance imagingLean humansObese humansHour oral glucose tolerance testOral glucose tolerance testSetting of hyperinsulinemiaGlucose tolerance testEuglycemic hyperinsulinemic clampEffect of hyperinsulinemiaAnterior cingulate cortexMagnetic resonance imagingWhole-brain analysisFood-seeking behaviorMiddle temporal gyrusMannKind CorporationCBF responseCNS effectsSatiety factorTolerance testBrain perfusionOB groupLN group
2013
Neural correlates of preparatory and regulatory control over positive and negative emotion
Seo D, Olman CA, Haut KM, Sinha R, MacDonald AW, Patrick CJ. Neural correlates of preparatory and regulatory control over positive and negative emotion. Social Cognitive And Affective Neuroscience 2013, 9: 494-504. PMID: 23887812, PMCID: PMC3989138, DOI: 10.1093/scan/nst115.Peer-Reviewed Original ResearchConceptsLateral prefrontal cortexEmotion regulationPrefrontal cortexGreater activationBrain activityCingulate cortexBilateral anterior prefrontal cortexRight lateral prefrontal cortexNegative emotion regulationActive emotion regulationCommon brain regionsAnterior prefrontal cortexVentromedial prefrontal cortexDorsomedial prefrontal cortexNegative emotional statesInferior parietal lobeFunctional magnetic resonanceBilateral dorsomedial prefrontal cortexPosterior cingulate cortexAnterior cingulate cortexMain effectRight precentral gyrusEmotional valencePositive emotionsNegative emotions
2010
Sex differences in neural responses to stress and alcohol context cues
Seo D, Jia Z, Lacadie CM, Tsou KA, Bergquist K, Sinha R. Sex differences in neural responses to stress and alcohol context cues. Human Brain Mapping 2010, 32: 1998-2013. PMID: 21162046, PMCID: PMC3236497, DOI: 10.1002/hbm.21165.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexMedial prefrontal cortexRostral anterior cingulate cortexAlcohol cue exposureOrbitofrontal cortexContext cuesNeural responsesFunctional magnetic resonance imagingSex differencesVentral striatum activityLeft dorsal striatumMiddle frontal gyrusMedial orbitofrontal cortexAlcohol-related behaviorsStress-related activationCognitive processingVentromedial PFCNeural correlatesSex-specific vulnerabilityNeural processingPersonalized stressStriatum activityAnterior insulaBrain responsesFrontal gyrus