2023
Abstract 18205: Ethnicity and Aortic Stenosis: Presentation, Management and Outcomes
Biswas D, Wu J, Bharucha A, Fairhurst N, Kaye G, Baghai M, Dworakowski R, Byrne J, MacCarthy P, Shah A, Eskandari M, O'Gallagher K. Abstract 18205: Ethnicity and Aortic Stenosis: Presentation, Management and Outcomes. Circulation 2023, 148: a18205-a18205. DOI: 10.1161/circ.148.suppl_1.18205.Peer-Reviewed Original ResearchAortic valve replacementTranscatheter aortic valve implantationAsian patientsWhite patientsBlack patientsSevere ASAortic stenosisBenefit of transcatheter aortic valve implantationSurgical aortic valve replacementManagement of aortic stenosisCox multivariate analysisSocial deprivationManagement of ASAortic valve implantationTAVI interventionKing's College HospitalEthnicity-based differencesValve replacementCardiac symptomsCollege HospitalElectronic health recordsMortality benefitValve implantationMultivariate analysisAS diagnosis
2019
Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse
Chemi F, Rothwell D, McGranahan N, Gulati S, Abbosh C, Pearce S, Zhou C, Wilson G, Jamal-Hanjani M, Birkbak N, Pierce J, Kim C, Ferdous S, Burt D, Slane-Tan D, Gomes F, Moore D, Shah R, Al Bakir M, Hiley C, Veeriah S, Summers Y, Crosbie P, Ward S, Mesquita B, Dynowski M, Biswas D, Tugwood J, Blackhall F, Miller C, Hackshaw A, Brady G, Swanton C, Dive C. Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse. Nature Medicine 2019, 25: 1534-1539. PMID: 31591595, PMCID: PMC6986897, DOI: 10.1038/s41591-019-0593-1.Peer-Reviewed Original ResearchConceptsNon-small-cell lung cancerEarly-stage non-small-cell lung cancerDisease relapseGenomic profilingHigh risk of recurrenceDetection of circulating tumor cellsRisk of recurrenceTumor cell disseminationTime of surgeryPredictors of relapsePotential clinical utilityCurative intentPrimary tumorSurgical resectionTumor resectionTumor stagePredicting relapseCell disseminationTumor cellsLung cancerMutational overlapRelapseMultivariate analysisSurgeryHigh risk