2024
Cancer cell – Fibroblast crosstalk via HB-EGF, EGFR, and MAPK signaling promotes the expression of macrophage chemo-attractants in squamous cell carcinoma
Giangreco G, Rullan A, Naito Y, Biswas D, Liu Y, Hooper S, Nenclares P, Bhide S, Chon U Cheang M, Chakravarty P, Hirata E, Swanton C, Melcher A, Harrington K, Sahai E. Cancer cell – Fibroblast crosstalk via HB-EGF, EGFR, and MAPK signaling promotes the expression of macrophage chemo-attractants in squamous cell carcinoma. IScience 2024, 27: 110635. PMID: 39262776, PMCID: PMC11387794, DOI: 10.1016/j.isci.2024.110635.Peer-Reviewed Original ResearchTumor microenvironmentSquamous cell carcinoma cohortCancer cellsMacrophage chemo-attractantsSquamous cell carcinomaTumor-stroma crosstalkRecruitment of macrophagesExpression of CSF2Prognostic significanceCarcinoma cohortCell carcinomaPatient prognosisHB-EGFStromal fibroblastsCancer outcomesCancer progressionCancerMAPK signalingIndicator of signalingChemo-attractantsCellsFibroblastsCarcinomaExpressionEGFR
2022
Abstract LB064: B cells synergize with T cell regulation at immune hotspots in lung squamous cell carcinoma
Zhang H, AbdulJabbar K, Moore D, Akarca A, Enfield K, Jamal-Hanjani M, Raza S, Veeriah S, Biswas D, Salgado R, McGranahan N, Quesne J, Swanton C, Marafioti T, Yuan Y. Abstract LB064: B cells synergize with T cell regulation at immune hotspots in lung squamous cell carcinoma. Cancer Research 2022, 82: lb064-lb064. DOI: 10.1158/1538-7445.am2022-lb064.Peer-Reviewed Original ResearchTertiary lymphoid structuresSquamous cell carcinomaLung squamous cell carcinomaCD8+ T cellsCell carcinomaT cell regulationB cellsT cellsTumor nestsAmerican Association for Cancer Research annual meetingsLymphoid aggregatesTumor-infiltrating CD8+ T cellsPresence of tertiary lymphoid structuresCD4+Foxp3+ T cellsAssociated with poor overall survivalSubpopulation of T cellsHeterogeneous immune infiltrationT regulatory cellsRobust prognostic markersImmune cell aggregatesT cell subtypesT cytotoxic cellsTherapeutic targetImmune cell subpopulationsPoor overall survival