Featured Publications
A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer
Wu Y, Biswas D, Usaite I, Angelova M, Boeing S, Karasaki T, Veeriah S, Czyzewska-Khan J, Morton C, Joseph M, Hessey S, Reading J, Georgiou A, Al-Bakir M, McGranahan N, Jamal-Hanjani M, Hackshaw A, Quezada S, Hayday A, Swanton C. A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer. Nature Cancer 2022, 3: 696-709. PMID: 35637401, PMCID: PMC9236901, DOI: 10.1038/s43018-022-00376-z.Peer-Reviewed Original ResearchConceptsT cell populationsT cellsLung tissueLung cancerCD8+ T cellsNonsmall-cell lung cancerNonsmall cell lung cancerEffector memory phenotypeT cell compartmentCell lung cancerAssociated with survivalNonmalignant lung tissuesStem-like featuresNontumor lung tissuesT cell biologyHuman lung tissueImmunotherapeutic strategiesMemory phenotypeNatural killerLung tumorsTissue-residentPost-surgeryResident memoryMurine tissuesTumor
2022
Abstract 5636: V-delta-1 T cells are resident in the human lung and associate with survival in patients with non-small cell lung cancer in the TRACERx Study
Wu Y, Biswas D, Usaite I, Mihaela A, Boeing S, Karasaki T, Veeriah S, Czyzewska-Khan J, Reading J, Georgiou A, Al-Bakir M, McGranahan N, Jamal-Hanjani M, Hackshaw A, Consortium T, Quezada S, Hayday A, Swanton C. Abstract 5636: V-delta-1 T cells are resident in the human lung and associate with survival in patients with non-small cell lung cancer in the TRACERx Study. Cancer Research 2022, 82: 5636-5636. DOI: 10.1158/1538-7445.am2022-5636.Peer-Reviewed Original ResearchNon-small cell lung cancerCell lung cancerT cell compartmentV delta 1T cellsAssociated with survivalLung cancerTRACERx studyLung tissueAmerican Association for Cancer Research annual meetingsStage I-III non-small cell lung cancerT cell knockout miceCD8+ T cellsMurine tissuesFirst-in-human clinical trialIL-17-producingNon-malignant lung tissueT-cell immunotherapyT-cell receptor sequencingT cell clonesIL-17 productionT helper 1Acute myeloid leukemiaSusceptibility to carcinogenesisHuman lungAbstract LB064: B cells synergize with T cell regulation at immune hotspots in lung squamous cell carcinoma
Zhang H, AbdulJabbar K, Moore D, Akarca A, Enfield K, Jamal-Hanjani M, Raza S, Veeriah S, Biswas D, Salgado R, McGranahan N, Quesne J, Swanton C, Marafioti T, Yuan Y. Abstract LB064: B cells synergize with T cell regulation at immune hotspots in lung squamous cell carcinoma. Cancer Research 2022, 82: lb064-lb064. DOI: 10.1158/1538-7445.am2022-lb064.Peer-Reviewed Original ResearchTertiary lymphoid structuresSquamous cell carcinomaLung squamous cell carcinomaCD8+ T cellsCell carcinomaT cell regulationB cellsT cellsTumor nestsAmerican Association for Cancer Research annual meetingsLymphoid aggregatesTumor-infiltrating CD8+ T cellsPresence of tertiary lymphoid structuresCD4+Foxp3+ T cellsAssociated with poor overall survivalSubpopulation of T cellsHeterogeneous immune infiltrationT regulatory cellsRobust prognostic markersImmune cell aggregatesT cell subtypesT cytotoxic cellsTherapeutic targetImmune cell subpopulationsPoor overall survival