2023
The use of continuous positive airway pressure in COPD-OSA overlap syndrome: A systematic review
Srivali N, Thongprayoon C, Tangpanithandee S, Cheungpasitporn W, Won C. The use of continuous positive airway pressure in COPD-OSA overlap syndrome: A systematic review. Sleep Medicine 2023, 108: 55-60. PMID: 37336060, DOI: 10.1016/j.sleep.2023.05.025.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive sleep apneaDefinition of COPDCPAP therapyOverlap syndromeSystematic reviewCOPD exacerbationsCPAP usageClinical outcomesContinuous positive airway pressure therapyPositive airway pressure therapyContinuous positive airway pressureNewcastle-Ottawa Quality ScaleAirway pressure therapyPositive airway pressureObstructive pulmonary diseaseMeta-Analyses (PRISMA) statementPreferred Reporting ItemsComprehensive systematic reviewAirway pressurePulmonary diseaseSleep apneaPressure therapyPatient populationReporting ItemsInternational Consensus Statement on Obstructive Sleep Apnea
Chang JL, Goldberg AN, Alt JA, Mohammed A, Ashbrook L, Auckley D, Ayappa I, Bakhtiar H, Barrera J, Bartley B, Billings M, Boon M, Bosschieter P, Braverman I, Brodie K, Cabrera‐Muffly C, Caesar R, Cahali M, Cai Y, Cao M, Capasso R, Caples S, Chahine L, Chang C, Chang K, Chaudhary N, Cheong C, Chowdhuri S, Cistulli P, Claman D, Collen J, Coughlin K, Creamer J, Davis E, Dupuy‐McCauley K, Durr M, Dutt M, Ali M, Elkassabany N, Epstein L, Fiala J, Freedman N, Gill K, Gillespie M, Golisch L, Gooneratne N, Gottlieb D, Green K, Gulati A, Gurubhagavatula I, Hayward N, Hoff P, Hoffmann O, Holfinger S, Hsia J, Huntley C, Huoh K, Huyett P, Inala S, Ishman S, Jella T, Jobanputra A, Johnson A, Junna M, Kado J, Kaffenberger T, Kapur V, Kezirian E, Khan M, Kirsch D, Kominsky A, Kryger M, Krystal A, Kushida C, Kuzniar T, Lam D, Lettieri C, Lim D, Lin H, Liu S, MacKay S, Magalang U, Malhotra A, Mansukhani M, Maurer J, May A, Mitchell R, Mokhlesi B, Mullins A, Nada E, Naik S, Nokes B, Olson M, Pack A, Pang E, Pang K, Patil S, Van de Perck E, Piccirillo J, Pien G, Piper A, Plawecki A, Quigg M, Ravesloot M, Redline S, Rotenberg B, Ryden A, Sarmiento K, Sbeih F, Schell A, Schmickl C, Schotland H, Schwab R, Seo J, Shah N, Shelgikar A, Shochat I, Soose R, Steele T, Stephens E, Stepnowsky C, Strohl K, Sutherland K, Suurna M, Thaler E, Thapa S, Vanderveken O, de Vries N, Weaver E, Weir I, Wolfe L, Woodson B, Won C, Xu J, Yalamanchi P, Yaremchuk K, Yeghiazarians Y, Yu J, Zeidler M, Rosen I. International Consensus Statement on Obstructive Sleep Apnea. International Forum Of Allergy & Rhinology 2023, 13: 1061-1482. PMID: 36068685, PMCID: PMC10359192, DOI: 10.1002/alr.23079.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObstructive sleep apneaEvidence-based reviewPositive airway pressureInternational consensus statementSleep apneaConsensus statementAdult OSA patientsMultiple treatment modalitiesSleep apnea evaluationAirway pressureOSA patientsPAP adherenceSurgical treatmentEvidence-based practiceOSA treatmentLongitudinal careTreatment modalitiesClinical managementRisk factorsHealth risk outcomesStudy qualitySyndrome definitionCurrent evidenceRecommendation formatOSA disease
2022
In-office communication about excessive daytime sleepiness associated with treated obstructive sleep apnea: insights from an ethnographic study of physician-patient visits
Won C, Bogan R, Doghramji K, Ojile J, Bujanover S, Hyman D, Hewett K, Thomas R. In-office communication about excessive daytime sleepiness associated with treated obstructive sleep apnea: insights from an ethnographic study of physician-patient visits. Sleep Science And Practice 2022, 6: 4. DOI: 10.1186/s41606-022-00072-y.Peer-Reviewed Original ResearchObstructive sleep apneaProvider-patient communicationSleep apneaDaytime sleepinessPositive airway pressure therapyPhysician-patient visitsAirway pressure therapyExcessive daytime sleepinessEpworth Sleepiness ScaleQuality of lifePost-visit interviewsTherapy initiationAdult patientsAirway therapyPressure therapyPatient educationSleepiness ScalePrimary symptomsPatientsRoutine useScreening toolEDS symptomsVisitsPhysiciansApnea
2021
Identification of Sleep Medicine and Anesthesia Core Topics for Anesthesia Residency: A Modified Delphi Technique Survey
Berezin L, Nagappa M, Wong J, Clivatti J, Singh M, Auckley D, Charchaflieh JG, Fagerlund M, Gali B, Joshi GP, Overdyk FJ, Margarson M, Mokhlesi B, Moon T, Ramachandran SK, Ryan CM, Schumann R, Weingarten TN, Won CHJ, Chung F. Identification of Sleep Medicine and Anesthesia Core Topics for Anesthesia Residency: A Modified Delphi Technique Survey. Anesthesia & Analgesia 2021, 132: 1223-1230. PMID: 33857964, DOI: 10.1213/ane.0000000000005446.Peer-Reviewed Original ResearchMeSH KeywordsAnesthesiaAnesthesiologistsAnesthesiologyClinical CompetenceConsensusCross-Sectional StudiesCurriculumDelphi TechniqueEducation, Medical, GraduateFemaleHumansInternship and ResidencyMalePostoperative ComplicationsProspective StudiesRisk AssessmentRisk FactorsSleep Apnea SyndromesSleep Medicine SpecialtySurgical Procedures, OperativeConceptsSleep medicineSleep disordersMedicine topicsProspective cross-sectional surveyUpper airway obstructionAdverse perioperative eventsUpper airway patencyInfluence of opioidsControl of breathingCross-sectional surveyDelphi technique surveyEffects of sleepPractice of anesthesiologyAirway obstructionAirway patencyAnesthetic managementPerioperative eventsAnesthetic implicationsSleep apneaHypnotic medicationsField of anesthesiaAnesthetic agentsGeneral populationAnesthesiaAnesthesia residency
2019
Sex differences in obstructive sleep apnea phenotypes, the multi-ethnic study of atherosclerosis
Won C, Reid M, Sofer T, Azarbarzin A, Purcell S, White D, Wellman A, Sands S, Redline S. Sex differences in obstructive sleep apnea phenotypes, the multi-ethnic study of atherosclerosis. Sleep 2019, 43: zsz274. PMID: 31687772, PMCID: PMC7215264, DOI: 10.1093/sleep/zsz274.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexObstructive sleep apneaMulti-Ethnic StudyArousal criteriaObstructive sleep apnea phenotypesSex differencesLow arousal thresholdRelative sex differencesApnea phenotypesNREM-AHIPathophysiological endotypesREM-OSAAirway collapsibilityOSA prevalenceSleep apneaDesaturation criteriaEndotypesSex disparitiesArousal thresholdPolysomnography dataSignificant sex differencesREM eventsWomenLow loop gainNREMAssessing Communication Between Physicians and Patients with Excessive Daytime Sleepiness Associated with Treated Obstructive Sleep Apnea: Insights from an Ethnographic Study of In-Office Visits
Won C, Bogan R, Doghramji K, Ojile J, Bujanover S, Hyman D, Hewett K, Thomas R. Assessing Communication Between Physicians and Patients with Excessive Daytime Sleepiness Associated with Treated Obstructive Sleep Apnea: Insights from an Ethnographic Study of In-Office Visits. 2019, a1390-a1390. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1390.Peer-Reviewed Original Research
2018
Varying Hypopnea Definitions Affect Obstructive Sleep Apnea Severity Classification and Association With Cardiovascular Disease.
Won CHJ, Qin L, Selim B, Yaggi HK. Varying Hypopnea Definitions Affect Obstructive Sleep Apnea Severity Classification and Association With Cardiovascular Disease. Journal Of Clinical Sleep Medicine 2018, 14: 1987-1994. PMID: 30518445, PMCID: PMC6287733, DOI: 10.5664/jcsm.7520.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaHypopnea definitionsDesaturation criteriaOdds ratioCardiovascular diseaseOSA diagnosisSeverity of OSAModerate obstructive sleep apneaSevere obstructive sleep apneaDifferent hypopnea definitionsLess smoking historySleep-disordered breathingIschemic heart diseaseSignificant risk factorsCross-sectional analysisArousal definitionHypopnea criteriaCardiovascular riskOSA severitySmoking historyHeart failureClinical featuresSleep apneaOSA groupRisk factorsDiagnosing and Treating Sleep Apnea in Patients With Acute Cerebrovascular Disease
Bravata DM, Sico J, Fragoso C, Miech EJ, Matthias MS, Lampert R, Williams LS, Concato J, Ivan CS, Fleck JD, Tobias L, Austin C, Ferguson J, Radulescu R, Iannone L, Ofner S, Taylor S, Qin L, Won C, Yaggi HK. Diagnosing and Treating Sleep Apnea in Patients With Acute Cerebrovascular Disease. Journal Of The American Heart Association 2018, 7: e008841. PMID: 30369321, PMCID: PMC6201384, DOI: 10.1161/jaha.118.008841.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressure usePositive airway pressure useTransient ischemic attackRankin Scale scoreIschemic stroke/transient ischemic attackStroke/transient ischemic attackBackground Obstructive sleep apneaHealth Stroke ScaleIschemic attackScale scoreStroke ScaleIschemic strokeTreat analysisSleep apneaAcute ischemic stroke/transient ischemic attackHealth Stroke Scale scoreNational InstituteContinuous positive airway pressureModified Rankin Scale scoreNeurological functioningNeurological symptom severityRecent ischemic strokeStroke Scale scoreAcute cerebrovascular diseaseAcute ischemic stroke
2017
Impact of Sleep Breathing Disorders in Obese Critically Ill Patients
Al-Halawani M, Won C. Impact of Sleep Breathing Disorders in Obese Critically Ill Patients. 2017, 77-85. DOI: 10.1007/978-3-319-49253-7_8.Peer-Reviewed Original ResearchSleep breathing disordersBreathing disordersObesity hypoventilation syndromeObstructive sleep apneaSleep-disordered breathingIntensive care unitObese patientsHypoventilation syndromeIll patientsCare unitSleep apneaIll populationMajor causeObesePatientsDisordersRiskSerious riskApneaICUMorbidityComplicationsSyndromeMortalityBreathing
2016
The use of positive airway pressure therapy for treatment of resistant hypertension
Won C, Guilleminault C. The use of positive airway pressure therapy for treatment of resistant hypertension. Expert Review Of Cardiovascular Therapy 2016, 14: 505-511. PMID: 26671301, DOI: 10.1586/14779072.2016.1132626.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPositive airway pressure therapyObstructive sleep apneaAirway pressure therapyBlood pressure controlResistant hypertensionPressure therapyPressure controlSubgroup of patientsHigh-risk populationBlood pressureSleep apneaRisk factorsPathological mechanismsHypertensionNovel targetPatientsTherapyPotential mechanismsApneaMedicationsBreathingSleepTrials
2015
Gender differences in sleep disordered breathing: implications for therapy
Won C, Guilleminault C. Gender differences in sleep disordered breathing: implications for therapy. Expert Review Of Respiratory Medicine 2015, 9: 221-231. PMID: 25739831, DOI: 10.1586/17476348.2015.1019478.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep-disordered breathingSeverity of OSAUpper airway functionGender-related differencesAirway functionEndothelial dysfunctionLung functionComorbid conditionsSleep apneaTreatment optionsRespiratory stabilityImproved outcomesGender differencesGreater riskAdverse effectsWomenLimited dataAge increasesBreathingFemale presentationsHypertensionApneaAirwayPregnancy
2012
Severe obstructive sleep apnea increases mortality in patients with ischemic heart disease and myocardial injury
Won CH, Chun HJ, Chandra SM, Sarinas PS, Chitkara RK, Heidenreich PA. Severe obstructive sleep apnea increases mortality in patients with ischemic heart disease and myocardial injury. Sleep And Breathing 2012, 17: 85-91. PMID: 22294346, DOI: 10.1007/s11325-012-0653-y.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngina, UnstableBody Mass IndexCause of DeathCohort StudiesComorbidityContinuous Positive Airway PressureEchocardiographyFemaleFollow-Up StudiesHeart FailureHumansKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionMyocardial IschemiaPatient CompliancePolysomnographyPrognosisRiskRisk FactorsSleep Apnea, ObstructiveSurvival AnalysisTroponin IConceptsSevere obstructive sleep apneaObstructive sleep apneaIschemic heart diseaseSleep apneaMyocardial injuryHeart diseaseOSA groupMild-moderate obstructive sleep apneaModerate obstructive sleep apneaPrevious myocardial injuryAdjusted hazard ratioRetrospective cohort studyConsecutive OSA patientsElevated troponin levelsSevere OSA groupRisk of deathDose-dependent impactCohort studyHazard ratioOSA patientsOSA severityTroponin levelsConclusionsThe severityRisk stratificationCardiac patients
2010
Cardiovascular Consequences of Sleep Apnea
Selim B, Won C, Yaggi HK. Cardiovascular Consequences of Sleep Apnea. Clinics In Chest Medicine 2010, 31: 203-220. PMID: 20488282, DOI: 10.1016/j.ccm.2010.02.010.ChaptersConceptsObstructive sleep apneaCardiovascular diseaseSleep apneaTreatment of OSAImportant public health challengeNonfatal cardiovascular eventsSpecific cardiovascular outcomesSleep-disordered breathingCardiovascular health outcomesEpidemic of obesityBurden of diseaseCause of deathGeneral adult populationNovel therapeutic approachesPublic health challengeCardiovascular eventsCardiovascular outcomesCause mortalityCardiovascular consequencesMyocardial ischemiaTherapeutic approachesHealth outcomesAdult populationHealth challengesNovel target
2009
Obstructive Sleep Apnea
Won C, Kim J, Guilleminault C. Obstructive Sleep Apnea. 2009, 563-565. DOI: 10.1002/9781444317008.ch145.Peer-Reviewed Original Research
2008
Surgical Treatment of Obstructive Sleep Apnea
Won CH, Li KK, Guilleminault C. Surgical Treatment of Obstructive Sleep Apnea. Annals Of The American Thoracic Society 2008, 5: 193-199. PMID: 18250212, DOI: 10.1513/pats.200708-121mg.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObstructive sleep apneaPositive airway pressure therapySevere obstructive sleep apneaAirway pressure therapyRadiofrequency ablationMaxillomandibular advancementSleep apneaPressure therapyMaxillomandibular deficiencyUpper airway surgeryUpper airway obstructionImportant treatment optionLaser-assisted uvulopalatoplastyProper patient selectionImportant therapeutic considerationProper procedure selectionGenioglossal advancementRetrolingual obstructionUvulopalatal flapAirway obstructionNasal obstructionSurgical treatmentAirway surgeryPatient selectionMost surgeries