2022
Induction of the activating transcription factor-4 in the intratumoral CD8+ T cells sustains their viability and anti-tumor activities
Lu Z, Bae E, Verginadis I, Zhang H, Cho C, McBrearty N, George S, Diehl J, Koumenis C, Bradley L, Fuchs S. Induction of the activating transcription factor-4 in the intratumoral CD8+ T cells sustains their viability and anti-tumor activities. Cancer Immunology, Immunotherapy 2022, 72: 815-826. PMID: 36063172, PMCID: PMC10317204, DOI: 10.1007/s00262-022-03286-2.Peer-Reviewed Original ResearchConceptsActivity of CD8Tumor-derived factorsT cellsTumor microenvironmentTranscription factor 4Anti-tumor immunityImmune suppressive factorsFactor 4Anti-tumor activityFunction of ATF4Anti-cancer therapyIntratumoral CD8Cytotoxic CD8Immune therapyTherapeutic regimensAntigenic stimulationCD8Suppressive factorsT lymphocytesMouse modelImpaired activationWild-type counterpartsSelective ablationTherapyInduction of ATF4
2020
Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs
Gui J, Zahedi F, Ortiz A, Cho C, Katlinski K, Alicea-Torres K, Li J, Todd L, Zhang H, Beiting D, Sander C, Kirkwood J, Snow B, Wakeham A, Mak T, Diehl J, Koumenis C, Ryeom S, Stanger B, Puré E, Gabrilovich D, Fuchs S. Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs. Nature Cancer 2020, 1: 603-619. PMID: 34124690, PMCID: PMC8194112, DOI: 10.1038/s43018-020-0064-0.Peer-Reviewed Original ResearchConceptsPre-metastatic nicheFibroblast activation proteinStress-activated protein kinasePrimary tumor-derived factorsActivation proteinDisseminated malignant cellsNormal cellsActivity of p38Tumor-derived factorsExpression of chemokinesActivation of p38αInactivation of p38Subsequent pulmonary metastasesStimulation of expressionType I interferonProtein kinaseLung infiltrationP38 inhibitorAdjuvant therapyMetastatic diseaseP38α kinasePulmonary metastasesLung metastasesPoor prognosisMetastatic cancer