2020
Fibronectin in the Tumor Microenvironment Activates a TLR4-dependent Inflammatory Response in Lung Cancer Cells
Cho C, Horzempa C, Longo CM, Peters DM, Jones DM, McKeown-Longo PJ. Fibronectin in the Tumor Microenvironment Activates a TLR4-dependent Inflammatory Response in Lung Cancer Cells. Journal Of Cancer 2020, 11: 3099-3105. PMID: 32231714, PMCID: PMC7097952, DOI: 10.7150/jca.39771.Peer-Reviewed Original ResearchType III domainExtracellular matrixLung cancer cellsFibronectin type III domainTumor-associated extracellular matrixCancer cellsFibronectin-rich extracellular matrixTLR4-dependent inflammatory responsesRich extracellular matrixFirst Type III domainIL-8Secondary structureStrained conformationMatrix fibronectinNF-κB pathwayEssential roleFibrotic microenvironmentTumor metastasisPathwayConformational labilityStromal cellsTumor progressionCytokine releaseLung cancerInflammatory response
2016
The fibronectin III-1 domain activates a PI3-Kinase/Akt signaling pathway leading to αvβ5 integrin activation and TRAIL resistance in human lung cancer cells
Cho C, Horzempa C, Jones D, McKeown-Longo PJ. The fibronectin III-1 domain activates a PI3-Kinase/Akt signaling pathway leading to αvβ5 integrin activation and TRAIL resistance in human lung cancer cells. BMC Cancer 2016, 16: 574. PMID: 27484721, PMCID: PMC4970220, DOI: 10.1186/s12885-016-2621-6.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Non-Small-Cell LungCaspase 8Cell Line, TumorCell SurvivalDrug Resistance, NeoplasmFibronectin Type III DomainFibronectinsGene Expression Regulation, NeoplasticHumansLung NeoplasmsPhosphatidylinositol 3-KinasesProtein FoldingProto-Oncogene Proteins c-aktReceptors, VitronectinSignal TransductionTNF-Related Apoptosis-Inducing LigandVitronectinConceptsType III domainLung cancer cellsUnfolded domainsTRAIL resistancePI3-kinase/AktSerine/threonine kinase pathwaysCancer cellsMulti-modular proteinThreonine kinase pathwaysNCI-H460 lung cancer cellsFnIII-1cFirst Type III domainNon-small cell lung cancer cellsTRAIL-induced apoptosisΑvβ5 integrin receptorLung cancer resistanceCell lung cancer cellsHuman lung cancer cellsKinase pathwayCancer cell resistanceIntegrin activationCaspase-8Signaling pathwaysFibronectin matrixSensitive proteinsThe Fibronectin III‐1 Domain Activates a PI3‐Kinase/Akt Signaling Pathway Leading to αvβ5 Integrin Activation and TRAIL Resistance in Human Lung Cancer Cells
Cho C, McKeown‐Longo P. The Fibronectin III‐1 Domain Activates a PI3‐Kinase/Akt Signaling Pathway Leading to αvβ5 Integrin Activation and TRAIL Resistance in Human Lung Cancer Cells. The FASEB Journal 2016, 30: lb82-lb82. DOI: 10.1096/fasebj.30.1_supplement.lb82.Peer-Reviewed Original ResearchLung cancer cellsTRAIL resistanceNon-small cell lung cancerH460 lung cancer cellsCancer cellsCell lung cancerHuman lung cancer cellsLung cancer resistancePI3K/Akt pathwayTumor-stroma interfaceCancer cell resistanceAkt Signaling PathwayΑvβ5 integrin receptorLung cancerImmunohistochemical stainingTumor stromaFirst Type III domainFnIII-1cDrug resistanceBlood vesselsAkt pathwayCancer resistanceSignaling pathwaysFibronectin contributesSubsequent apoptosis