2021
An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function
Lin W, Zhao Y, Li Z, Zheng S, Zou J, Warren N, Bali P, Wu J, Xing M, Jiang C, Tang Y, Salton S, Ye X. An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function. Translational Psychiatry 2021, 11: 383. PMID: 34238925, PMCID: PMC8266826, DOI: 10.1038/s41398-021-01489-2.Peer-Reviewed Original ResearchConceptsDense-core vesiclesTLQP-62VGF-derived peptide TLQP-62Cognitive functionGranin familyDepression-like behaviorRelease of neuropeptidesGranin proteinsHippocampus-dependent learningCultured primary neuronsLuciferase-based reporter assayGranin family proteinsTranscription-independent inductionNeuronal activationMood disordersAutofeedback mechanismNeuronal activityPrimary neuronsVGF expressionMice exhibitMood stabilityAlzheimer's diseaseBrain tissueMRNA expressionNeurodegenerative diseases
2020
Chapter 7 Neuroprotective roles of neurotrophic growth factors in mood disorders
Jiang C, Salton S. Chapter 7 Neuroprotective roles of neurotrophic growth factors in mood disorders. 2020, 145-172. DOI: 10.1016/b978-0-12-814037-6.00010-0.Peer-Reviewed Original ResearchBrain-derived neurotrophic factorNeurotrophic growth factorsMood disordersAntidepressant efficacyDepressive behaviorGrowth factorDepression-like behaviorAntidepressant actionAntidepressant responseDendritic lengthNeuroprotective roleSpine densityNeurotrophic factorNeurotrophin actionNeuronal cytoarchitectureAnimal modelsGene polymorphismsSynaptic plasticityProtein levelsDisordersReceptorsGenetic associationEfficacySpecific mechanismsCritical role
2019
Grape‐derived polyphenols produce antidepressant effects via VGF‐ and BDNF‐dependent mechanisms
Jiang C, Sakakibara E, Lin W, Wang J, Pasinetti GM, Salton SR. Grape‐derived polyphenols produce antidepressant effects via VGF‐ and BDNF‐dependent mechanisms. Annals Of The New York Academy Of Sciences 2019, 1455: 196-205. PMID: 31074515, PMCID: PMC6834858, DOI: 10.1111/nyas.14098.Peer-Reviewed Original ResearchConceptsDepression-like behaviorAntidepressant efficacyTLQP-62VGF-derived peptide TLQP-62Stress-induced depression-like behaviorsBDNF-dependent mechanismAntidepressant-like effectsChronic variable stressGrape-derived polyphenolsAntidepressant actionAntidepressant effectsBDNF expressionNaive miceDorsal hippocampusPolyphenol preparationsFloxed miceVGF expressionPrior knockdownEfficacyVGFMiceMolecular mechanismsRecent studiesVariable stressBDNF
2018
Role of a VGF/BDNF/TrkB Autoregulatory Feedback Loop in Rapid-Acting Antidepressant Efficacy
Jiang C, Lin WJ, Salton SR. Role of a VGF/BDNF/TrkB Autoregulatory Feedback Loop in Rapid-Acting Antidepressant Efficacy. Journal Of Molecular Neuroscience 2018, 68: 504-509. PMID: 30022437, PMCID: PMC6338529, DOI: 10.1007/s12031-018-1124-0.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorRapid-acting antidepressantsTLQP-62Antidepressant efficacyReceptor activationN-methyl-D-aspartate receptorsParticular brain-derived neurotrophic factorIsoxazolepropionic acid receptor (AMPAR) activationBDNF/TrkBDepression-like behaviorRapid antidepressant actionsIntra-hippocampal administrationAMPA receptor activationExpression of VGFChemical antidepressantsAntidepressant actionBDNF expressionSustained efficacyNeurotrophic factorNeurotrophin familySwim testVoluntary exerciseMTOR pathwayMTOR activationAntidepressants
2017
VGF function in depression and antidepressant efficacy
Jiang C, Lin WJ, Sadahiro M, Labonté B, Menard C, Pfau ML, Tamminga CA, Turecki G, Nestler EJ, Russo SJ, Salton SR. VGF function in depression and antidepressant efficacy. Molecular Psychiatry 2017, 23: 1632-1642. PMID: 29158577, PMCID: PMC5962361, DOI: 10.1038/mp.2017.233.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntidepressive AgentsBrain-Derived Neurotrophic FactorDepressionDepressive DisorderDown-RegulationFemaleHippocampusHumansKetamineMaleMiceMice, Inbred C57BLMiddle AgedNerve Growth FactorsNeuronsNeuropeptidesNucleus AccumbensReceptors, AMPASex FactorsSignal TransductionStress, PsychologicalTOR Serine-Threonine KinasesUp-RegulationConceptsChronic social defeat stressDepression-like behaviorBrain-derived neurotrophic factorSocial defeat stressNucleus accumbensAntidepressant efficacyAntidepressant responseDefeat stressFloxed micePro-depressant effectsRapid antidepressant efficacyBDNF/TrkBIsoxazolepropionic acid (AMPA) receptorsWild-type miceDepressed human subjectsBDNF translationTLQP-62VGF levelsAAV-CreAntidepressant behaviorNeurotrophic factorSwim testDorsal hippocampusInhibitory interneuronsVGF expression