Cheng Jiang, PhD
Associate Research Scientist in Psychiatry
Research & Publications
Biography
Coauthors
Selected Publications
- The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actionsJiang C, DiLeone R, Pittenger C, Duman R. The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions. Translational Psychiatry 2024, 14: 90. PMID: 38346984, PMCID: PMC10861497, DOI: 10.1038/s41398-024-02796-0.
- Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasisSahu B, Razzoli M, McGonigle S, Pallais J, Nguyen M, Sadahiro M, Jiang C, Lin W, Kelley K, Rodriguez P, Mansk R, Cero C, Caviola G, Palanza P, Rao L, Beetch M, Alejandro E, Sham Y, Frontini A, Salton S, Bartolomucci A. Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis. Molecular Metabolism 2023, 76: 101781. PMID: 37482186, PMCID: PMC10400922, DOI: 10.1016/j.molmet.2023.101781.
- 348. Sexual Dimorphism in the Behavioral Outcomes Following Early Life StressJiang C, Pittenger C. 348. Sexual Dimorphism in the Behavioral Outcomes Following Early Life Stress. Biological Psychiatry 2023, 93: s234. DOI: 10.1016/j.biopsych.2023.02.588.
- P456. The Effects of Early Life Stress on Tourette Syndrome-Relevant PathologyJiang C, Pittenger C. P456. The Effects of Early Life Stress on Tourette Syndrome-Relevant Pathology. Biological Psychiatry 2022, 91: s272. DOI: 10.1016/j.biopsych.2022.02.692.
- An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive functionLin W, Zhao Y, Li Z, Zheng S, Zou J, Warren N, Bali P, Wu J, Xing M, Jiang C, Tang Y, Salton S, Ye X. An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function. Translational Psychiatry 2021, 11: 383. PMID: 34238925, PMCID: PMC8266826, DOI: 10.1038/s41398-021-01489-2.
- The Roles of Endogenous Opioid System in the Antidepressant Actions of KetamineJiang C, DiLeone R, Pittenger C, Duman R. The Roles of Endogenous Opioid System in the Antidepressant Actions of Ketamine. Biological Psychiatry 2021, 89: s385. DOI: 10.1016/j.biopsych.2021.02.956.
- Multiscale causal networks identify VGF as a key regulator of Alzheimer’s diseaseBeckmann ND, Lin WJ, Wang M, Cohain AT, Charney AW, Wang P, Ma W, Wang YC, Jiang C, Audrain M, Comella PH, Fakira AK, Hariharan SP, Belbin GM, Girdhar K, Levey AI, Seyfried NT, Dammer EB, Duong D, Lah JJ, Haure-Mirande JV, Shackleton B, Fanutza T, Blitzer R, Kenny E, Zhu J, Haroutunian V, Katsel P, Gandy S, Tu Z, Ehrlich ME, Zhang B, Salton SR, Schadt EE. Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease. Nature Communications 2020, 11: 3942. PMID: 32770063, PMCID: PMC7414858, DOI: 10.1038/s41467-020-17405-z.
- VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD miceEl Gaamouch F, Audrain M, Lin WJ, Beckmann N, Jiang C, Hariharan S, Heeger PS, Schadt EE, Gandy S, Ehrlich ME, Salton SR. VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice. Molecular Neurodegeneration 2020, 15: 4. PMID: 31924226, PMCID: PMC6954537, DOI: 10.1186/s13024-020-0357-x.
- Chapter 7 Neuroprotective roles of neurotrophic growth factors in mood disordersJiang C, Salton S. Chapter 7 Neuroprotective roles of neurotrophic growth factors in mood disorders. 2020, 145-172. DOI: 10.1016/b978-0-12-814037-6.00010-0.
- Grape‐derived polyphenols produce antidepressant effects via VGF‐ and BDNF‐dependent mechanismsJiang C, Sakakibara E, Lin W, Wang J, Pasinetti GM, Salton SR. Grape‐derived polyphenols produce antidepressant effects via VGF‐ and BDNF‐dependent mechanisms. Annals Of The New York Academy Of Sciences 2019, 1455: 196-205. PMID: 31074515, PMCID: PMC6834858, DOI: 10.1111/nyas.14098.
- VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamineJiang C, Lin WJ, Labonté B, Tamminga CA, Turecki G, Nestler EJ, Russo SJ, Salton SR. VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine. Neuropsychopharmacology 2018, 44: 971-981. PMID: 30504797, PMCID: PMC6462025, DOI: 10.1038/s41386-018-0277-4.
- α1- and β3-Adrenergic Receptor–Mediated Mesolimbic Homeostatic Plasticity Confers Resilience to Social Stress in Susceptible MiceZhang H, Chaudhury D, Nectow AR, Friedman AK, Zhang S, Juarez B, Liu H, Pfau ML, Aleyasin H, Jiang C, Crumiller M, Calipari ES, Ku SM, Morel C, Tzavaras N, Montgomery SE, He M, Salton SR, Russo SJ, Nestler EJ, Friedman JM, Cao JL, Han MH. α1- and β3-Adrenergic Receptor–Mediated Mesolimbic Homeostatic Plasticity Confers Resilience to Social Stress in Susceptible Mice. Biological Psychiatry 2018, 85: 226-236. PMID: 30336931, PMCID: PMC6800029, DOI: 10.1016/j.biopsych.2018.08.020.
- Role of a VGF/BDNF/TrkB Autoregulatory Feedback Loop in Rapid-Acting Antidepressant EfficacyJiang C, Lin WJ, Salton SR. Role of a VGF/BDNF/TrkB Autoregulatory Feedback Loop in Rapid-Acting Antidepressant Efficacy. Journal Of Molecular Neuroscience 2018, 68: 504-509. PMID: 30022437, PMCID: PMC6338529, DOI: 10.1007/s12031-018-1124-0.
- VGF function in depression and antidepressant efficacyJiang C, Lin WJ, Sadahiro M, Labonté B, Menard C, Pfau ML, Tamminga CA, Turecki G, Nestler EJ, Russo SJ, Salton SR. VGF function in depression and antidepressant efficacy. Molecular Psychiatry 2017, 23: 1632-1642. PMID: 29158577, PMCID: PMC5962361, DOI: 10.1038/mp.2017.233.
- VGF and its C-terminal peptide TLQP-62 regulate memory formation and depressive behavior via a BDNF-TrkB-dependent mechanismLin W, Jiang C, Sadahiro M, Bozdagi O, Vulchanova L, Russo S, Alberini C, Salton S. VGF and its C-terminal peptide TLQP-62 regulate memory formation and depressive behavior via a BDNF-TrkB-dependent mechanism. Neuropeptides 2017, 65: 129. DOI: 10.1016/j.npep.2017.02.005.
- The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule BiogenesisStephens SB, Edwards RJ, Sadahiro M, Lin WJ, Jiang C, Salton SR, Newgard CB. The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis. Cell Reports 2017, 20: 2480-2489. PMID: 28877479, PMCID: PMC5624795, DOI: 10.1016/j.celrep.2017.08.050.
- Embryonic ablation of neuronal VGF increases energy expenditure and reduces body weightJiang C, Lin WJ, Sadahiro M, Shin AC, Buettner C, Salton SR. Embryonic ablation of neuronal VGF increases energy expenditure and reduces body weight. Neuropeptides 2016, 64: 75-83. PMID: 28024880, PMCID: PMC5478485, DOI: 10.1016/j.npep.2016.12.005.
- VGF and Its C-Terminal Peptide TLQP-62 Regulate Memory Formation in Hippocampus via a BDNF-TrkB-Dependent MechanismLin WJ, Jiang C, Sadahiro M, Bozdagi O, Vulchanova L, Alberini CM, Salton SR. VGF and Its C-Terminal Peptide TLQP-62 Regulate Memory Formation in Hippocampus via a BDNF-TrkB-Dependent Mechanism. Journal Of Neuroscience 2015, 35: 10343-10356. PMID: 26180209, PMCID: PMC4502270, DOI: 10.1523/jneurosci.0584-15.2015.
- ErrataFargali S, Garcia AL, Sadahiro M, Jiang C, Janssen WG, Lin WJ, Cogliani V, Elste A, Mortillo S, Cero C, Veitenheimer B, Graiani G, Pasinetti GM, Mahata SK, Osborn JW, Huntley GW, Phillips GR, Benson DL, Bartolomucci A, Salton SR. Errata. The FASEB Journal 2015, 29: 2679-2679. PMID: 26032479, PMCID: PMC4763872, DOI: 10.1096/fj.13-239509err.
- Role of VGF-Derived Carboxy-Terminal Peptides in Energy Balance and Reproduction: Analysis of “Humanized” Knockin Mice Expressing Full-Length or Truncated VGFSadahiro M, Erickson C, Lin WJ, Shin AC, Razzoli M, Jiang C, Fargali S, Gurney A, Kelley KA, Buettner C, Bartolomucci A, Salton SR. Role of VGF-Derived Carboxy-Terminal Peptides in Energy Balance and Reproduction: Analysis of “Humanized” Knockin Mice Expressing Full-Length or Truncated VGF. Endocrinology 2015, 156: 1724-1738. PMID: 25675362, PMCID: PMC4398760, DOI: 10.1210/en.2014-1826.
- The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressureFargali S, Garcia AL, Sadahiro M, Jiang C, Janssen WG, Lin W, Cogliani V, Elste A, Mortillo S, Cero C, Veitenheimer B, Graiani G, Pasinetti GM, Mahata SK, Osborn JW, Huntley GW, Phillips GR, Benson DL, Bartolomucci A, Salton SR. The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure. The FASEB Journal 2014, 28: 2120-2133. PMID: 24497580, PMCID: PMC3986843, DOI: 10.1096/fj.13-239509.
- The role of neurotrophins in major depressive disorderJiang C, Salton S. The role of neurotrophins in major depressive disorder. Translational Neuroscience 2013, 4: 46-58. PMID: 23691270, PMCID: PMC3656715, DOI: 10.2478/s13380-013-0103-8.
- Role of Neurotrophins in the Development and Function of Neural Circuits That Regulate Energy HomeostasisFargali S, Sadahiro M, Jiang C, Frick AL, Indall T, Cogliani V, Welagen J, Lin WJ, Salton SR. Role of Neurotrophins in the Development and Function of Neural Circuits That Regulate Energy Homeostasis. Journal Of Molecular Neuroscience 2012, 48: 654-659. PMID: 22581449, PMCID: PMC3480664, DOI: 10.1007/s12031-012-9790-9.