Update on Renal Sympathetic Denervation for the Treatment of Hypertension
Rao A, Krishnan N. Update on Renal Sympathetic Denervation for the Treatment of Hypertension. Current Cardiology Reports 2022, 24: 1261-1271. PMID: 35895182, DOI: 10.1007/s11886-022-01753-x.Peer-Reviewed Original ResearchConceptsRenal sympathetic denervationTreatment of hypertensionRenal sympathetic nervesPathophysiology of hypertensionSympathetic denervationSympathetic nervesBlood pressureSafety of RSDRenal sympathetic nerve fibersAmbulatory blood pressure measurementsAntihypertensive drug useSham-controlled trialAdvanced kidney diseaseSympathetic nerve fibersLong-term efficacyPurpose of ReviewHypertensionBlood pressure measurementsExcellent safety profileModest treatment effectsLong-term safetyAntihypertensive medicationsAldosterone antagonistsCause mortalityNeurogenic controlResistant hypertensionDonor–Recipient Non-HLA Variants, Mismatches and Renal Allograft Outcomes: Evolving Paradigms
Jethwani P, Rao A, Bow L, Menon MC. Donor–Recipient Non-HLA Variants, Mismatches and Renal Allograft Outcomes: Evolving Paradigms. Frontiers In Immunology 2022, 13: 822353. PMID: 35432337, PMCID: PMC9012490, DOI: 10.3389/fimmu.2022.822353.Peer-Reviewed Original ResearchConceptsAllograft outcomesImportant recent dataRenal allograft outcomeAcute allograft rejectionKidney allograft outcomesDonor-recipient mismatchRecipient's immune systemNatural history studiesNon-HLA lociMajority of casesOrgan allocation processPolymorphic HLA genesAcute rejectionAllograft longevityAllograft lossMaintenance immunosuppressionTransplant outcomesAllograft rejectionImmune mechanismsPatient deathRecipient pairsDonor organsHLA variantsImmune systemOvert evidence