2019
Mapping human microbiome drug metabolism by gut bacteria and their genes
Zimmermann M, Zimmermann-Kogadeeva M, Wegmann R, Goodman AL. Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature 2019, 570: 462-467. PMID: 31158845, PMCID: PMC6597290, DOI: 10.1038/s41586-019-1291-3.Peer-Reviewed Original ResearchConceptsHuman gut bacteriaGut bacteriaHigh-throughput genetic analysisMicrobial gene productsDiverse cladeGene contentGenomic contentGene productsGenetic analysisMolecular mechanismsDrug metabolismBacteriaMultiple disease indicationsMetabolic activityDrug-metabolizing activityGut microbiomeMicrobiomeMetabolismDrug developmentMedical therapyTreatment delayMass spectrometryCladeDisease indicationsAdverse effects
2013
Experimental Approaches for Defining Functional Roles of Microbes in the Human Gut
Dantas G, Sommer MO, Degnan PH, Goodman AL. Experimental Approaches for Defining Functional Roles of Microbes in the Human Gut. Annual Review Of Microbiology 2013, 67: 459-475. PMID: 24024637, PMCID: PMC4718711, DOI: 10.1146/annurev-micro-092412-155642.Peer-Reviewed Original ResearchConceptsMicrobial communitiesFree-living microbial communitiesHigh-throughput DNA sequencingCulture-independent surveysGenome sequence projectHuman gutHost-microbe interactionsGut microbial communityMicrobial genomesGene contentMicrobial genesModel organismsHost-microbiota relationshipFunctional roleDNA sequencingFunction strategyModel systemExperimental approachUnderlying mechanismGenomeGutGenesMicrobesOrganismsSpecies