2024
Polypharmacy in elective lumbar spinal surgery for degenerative conditions with 24-month follow-up
Dietz N, Kumar C, Elsamadicy A, Bjurström M, Wong K, Jamieson A, Sharma M, Wang D, Ugiliweneza B, Drazin D, Boakye M. Polypharmacy in elective lumbar spinal surgery for degenerative conditions with 24-month follow-up. Scientific Reports 2024, 14: 25340. PMID: 39455709, PMCID: PMC11511981, DOI: 10.1038/s41598-024-76248-6.Peer-Reviewed Original ResearchConceptsDegenerative lumbar pathologySurgical site infectionSpinal surgeryPolypharmacy groupSite infectionLumbar pathologyFollow-upMedical complicationsElective lumbar spinal surgeryLumbar spinal surgeryUrinary tract infectionDegenerative lumbar conditionsReturn to the emergency departmentTract infectionsNon-polypharmacy groupSurgical patientsLumbar conditionsSurgeryPatientsComplicationsPolypharmacyEmergency departmentPrescribed medicationsMarketScan datasetDegenerative conditionsUtility of Risk Analysis Index for Assessing Morbidity in Patients Undergoing Posterior Spinal Fusion for Adult Spinal Deformity
Elsamadicy A, Sadeghzadeh S, Serrato P, Sayeed S, Hengartner A, Belkasim S, Khalid S, Lo S, Sciubba D. Utility of Risk Analysis Index for Assessing Morbidity in Patients Undergoing Posterior Spinal Fusion for Adult Spinal Deformity. World Neurosurgery 2024 PMID: 39321916, DOI: 10.1016/j.wneu.2024.09.089.Peer-Reviewed Original ResearchPosterior spinal fusionAdult spinal deformityRisk Analysis IndexLength of stayMFI-5Spinal fusionReceiver operating characteristicSpinal deformityFrail patientsMultivariate analysisModified 5-item frailty indexACS NSQIP databasePreoperative surgical planningRetrospective cohort studyNSQIP databasePatient ageAssess morbidityComplication riskPredicting 30-day readmissionCohort studySurgical planningNormal patientsAdvanced ageComplicationsPatientsThe Impact of Preoperative Spinal Injection Timing on the Postoperative Complications of Lumbar Fusion
Mirpuri P, Khalid S, Colliander R, King P, Tao X, Elsamadicy A, Mehta A, Adogwa O. The Impact of Preoperative Spinal Injection Timing on the Postoperative Complications of Lumbar Fusion. World Neurosurgery 2024, 190: e121-e128. PMID: 39002778, DOI: 10.1016/j.wneu.2024.07.050.Peer-Reviewed Original ResearchTransforaminal lumbar interbody fusionCSF leakSurgical complicationsComplication rateIncidence of CSF leakRate of CSF leakSecondary outcomesRate of surgical complicationsSurgical complication ratePostoperative surgical complicationsSurgical site infectionDay of surgeryLumbar interbody fusionPostoperative complicationsSite infectionWound disruptionPostoperative rateAdult patientsLumbar fusionInterbody fusionIncreased riskPrimary outcomePatientsSurgeryPrimary analysisIsolated unilateral alar ligamentous injury: illustrative cases
Reeves B, Valcarce-Aspegren M, Robert S, Elsamadicy A, Tucker A, Storm P, DiLuna M, Kundishora A. Isolated unilateral alar ligamentous injury: illustrative cases. Journal Of Neurosurgery Case Lessons 2024, 7: case23664. PMID: 38560931, PMCID: PMC10988229, DOI: 10.3171/case23664.Peer-Reviewed Original ResearchMagnetic resonance imagingCervical collarAdequate first-line treatmentAlar ligament injuryUpper cervical traumaMagnetic resonance imaging evidenceHard cervical collarRigid cervical collarFirst-line treatmentResolution of symptomsRigid external immobilizationNeck painNeck tendernessCervical traumaHalo fixationPediatric patientsDefinitive diagnosisNonsurgical managementCervical radiographsModerate courseFollow-upLigament strainExternal immobilizationOdontoid processPatientsReduced racial disparities among newborns with intraventricular hemorrhage
Sayeed S, Reeves B, Theriault B, Hengartner A, Ahsan N, Sadeghzadeh S, Elsamadicy E, DiLuna M, Elsamadicy A. Reduced racial disparities among newborns with intraventricular hemorrhage. Child's Nervous System 2024, 40: 2051-2059. PMID: 38526575, DOI: 10.1007/s00381-024-06369-w.Peer-Reviewed Original ResearchLength of stayIntroductionIntraventricular hemorrhageAdverse eventsMultivariate logistic regression analysisRate of adverse eventsPermanent neurological dysfunctionProlonged length of stayNational Inpatient Sample databaseRates of NECInpatient Sample databaseLogistic regression analysisIntraventricular hemorrhageAA patientsImpact of raceCost of admissionIndependent predictorsRate of mortalityPatient characteristicsMultivariate analysisPercentage of AAWhite patientsNeurological dysfunctionNewbornsPatient genderPatients
2023
Outcomes Following 2-Level Cervical Interventions with Cage-and-Plate, Zero-Profile, or Arthroplasty Constructs
Khalid S, Mirpuri P, Thomson K, Elsamadicy A, Massaad E, Deysher D, Khilwani H, Adogwa O, Shin J, Mehta A. Outcomes Following 2-Level Cervical Interventions with Cage-and-Plate, Zero-Profile, or Arthroplasty Constructs. World Neurosurgery 2023, 180: e607-e617. PMID: 37797683, DOI: 10.1016/j.wneu.2023.09.117.Peer-Reviewed Original ResearchConceptsAdditional surgeryCervical interventionsPlate constructZero-profileMedical complicationsAnterior cervical proceduresDisc height restorationPostoperative medical complicationsOutcomes of patientsCervical disc diseaseLogistic regression modelsCervical proceduresSecondary outcomesSurgical complicationsIndex interventionPrimary outcomeIndex procedureHeight restorationDisc diseasePatientsSurgeryArthroplastyMotion limitationArtificial discComplicationsLow‐Field Portable Magnetic Resonance Imaging for Post‐Thrombectomy Assessment of Ongoing Brain Injury
Sujijantarat N, Koo A, Jambor I, Malhotra A, Mazurek M, Parasuram N, Yadlapalli V, Chavva I, Lalwani D, Zabinska J, Roy J, Antonios J, Elsamadicy A, Renedo D, Hebert R, Schindler J, Gilmore E, Sansing L, de Havenon A, Olexa M, Schiff S, Iglesias J, Rosen M, Kimberly W, Petersen N, Sheth K, Matouk C. Low‐Field Portable Magnetic Resonance Imaging for Post‐Thrombectomy Assessment of Ongoing Brain Injury. Stroke Vascular And Interventional Neurology 2023, 3 DOI: 10.1161/svin.123.000921.Peer-Reviewed Original ResearchMechanical thrombectomyInterventional radiology suiteMagnetic resonance imagingRadiology suiteConventional MRIResonance imagingCerebral Infarction scoreOngoing brain injuryLarge vessel occlusionInfarct burdenRevascularization timeInfarct volumeClinical characteristicsInfarct progressionAdverse eventsIschemic changesMethods PatientsMedian timeBedside evaluationBrain injuryTimely imagingResults TwentyPatientsSubsequent imagingProcedural detailsFrailty and postoperative outcomes in brain tumor patients: a systematic review subdivided by tumor etiology
Qureshi H, Tabor J, Pickens K, Lei H, Vasandani S, Jalal M, Vetsa S, Elsamadicy A, Marianayagam N, Theriault B, Fulbright R, Qin R, Yan J, Jin L, O’Brien J, Morales-Valero S, Moliterno J. Frailty and postoperative outcomes in brain tumor patients: a systematic review subdivided by tumor etiology. Journal Of Neuro-Oncology 2023, 164: 299-308. PMID: 37624530, PMCID: PMC10522517, DOI: 10.1007/s11060-023-04416-1.Peer-Reviewed Original ResearchBrain tumor patientsTumor patientsPostoperative outcomesFrailty indexSystematic reviewBrain tumorsPrimary intracranial tumorsMethodsSystematic literature reviewPrognostic valueVestibular schwannomaPostsurgical outcomesBenign tumorsIntracranial tumorsLesion etiologyTumor outcomeExclusion criteriaMalignant lesionsPRISMA guidelinesPatientsConclusionOur reviewTumor pathologyUnique etiologyTumor typesFrailtyNeurosurgical oncologySocioeconomic and Racial/Ethnic Disparities in Perception of Health Status and Literacy in Spine Oncological Patients
Elsamadicy A, Wang C, Reeves B, Sherman J, Craft S, Rajjoub R, Koo A, Hersh A, Pennington Z, Lo S, Shin J, Mendel E, Sciubba D. Socioeconomic and Racial/Ethnic Disparities in Perception of Health Status and Literacy in Spine Oncological Patients. Spine 2023, 48: 1107-1115. PMID: 37163649, DOI: 10.1097/brs.0000000000004712.Peer-Reviewed Original ResearchConceptsNon-White HispanicsOncology patientsHigh response rateWhite/CaucasianHealth statusHealth literacyWC patientsResponse rateICD-9/10-CM codesOwn general healthSocioeconomic statusBaseline health statusRacial/Ethnic DisparitiesCross-sectional studyRace/ethnicityExcellent/Severe fatigueGeneral healthOncological patientsBACKGROUND DATADisease processHealthcare costsPatientsMedical careEthnic disparities
2022
Utilization of Machine Learning to Model Important Features of 30-day Readmissions following Surgery for Metastatic Spinal Column Tumors: The Influence of Frailty
Elsamadicy A, Koo A, Reeves B, Cross J, Hersh A, Hengartner A, Karhade A, Pennington Z, Akinduro O, Lo S, Gokaslan Z, Shin J, Mendel E, Sciubba D. Utilization of Machine Learning to Model Important Features of 30-day Readmissions following Surgery for Metastatic Spinal Column Tumors: The Influence of Frailty. Global Spine Journal 2022, 14: 1227-1237. PMID: 36318478, PMCID: PMC11289550, DOI: 10.1177/21925682221138053.Peer-Reviewed Original ResearchHospital Frailty Risk ScoreSpinal column tumorsFrailty Risk ScoreInfluence of frailtySpinal column metastasesProportion of patientsRetrospective cohort studyNationwide Readmissions DatabaseRisk of readmissionMultivariate regression analysisIntermediate frailtyAdult patientsCohort studyIndependent predictorsSurgical interventionSpine surgeryReadmissionPatient readmissionRisk scorePatientsFrailtySurgeryCohortTumorsRegression analysisResponse to letter to the Editor on ‘Utility of the Hospital Frailty Risk Score in patients undergoing endovascular treatment for ruptured aneurysms’
Koo A, Elsamadicy A, Renedo D, Matouk C. Response to letter to the Editor on ‘Utility of the Hospital Frailty Risk Score in patients undergoing endovascular treatment for ruptured aneurysms’. Journal Of NeuroInterventional Surgery 2022, 15: 307-308. PMID: 36319084, DOI: 10.1136/jnis-2022-019708.Peer-Reviewed Original ResearchResponse: Implications of HFRS in Patients Undergoing Surgery for Primary Spinal Intradural/Cord Tumors
Elsamadicy A, Koo A, Sciubba D. Response: Implications of HFRS in Patients Undergoing Surgery for Primary Spinal Intradural/Cord Tumors. Global Spine Journal 2022, 13: 256-256. PMID: 36154494, PMCID: PMC9837522, DOI: 10.1177/21925682221129552.Peer-Reviewed Original ResearchImpact of Frailty on Morbidity and Mortality in Adult Patients Undergoing Surgical Evacuation of Acute Traumatic Subdural Hematoma
Elsamadicy AA, Sandhu MRS, Freedman IG, Koo AB, Reeves BC, Yu J, Hengartner A, Havlik J, Hong CS, Rutherford HJV, Kim JA, Gerrard J, Gilmore EJ, Omay SB. Impact of Frailty on Morbidity and Mortality in Adult Patients Undergoing Surgical Evacuation of Acute Traumatic Subdural Hematoma. World Neurosurgery 2022, 162: e251-e263. PMID: 35276399, DOI: 10.1016/j.wneu.2022.02.122.Peer-Reviewed Original ResearchConceptsAcute traumatic subdural hematomaTraumatic subdural hematomaHospital mortalityNonroutine dischargeSubdural hematomaExtended LOSIndependent predictorsAdult patientsBaseline frailtyMultivariate logistic regression analysisExtended hospital lengthImpact of frailtyRetrospective cohort studyNational Trauma DatabaseLogistic regression analysisRegression analysisMultivariate regression analysisHealth care expendituresFrail patientsHospital lengthCohort studySurgical evacuationFrailty indexTrauma databasePatients
2021
Fenestrated pedicle screws for thoracolumbar instrumentation in patients with poor bone quality: Case series and systematic review of the literature
Ehresman J, Pennington Z, Elsamadicy AA, Hersh A, Lubelski D, Lehner K, Cottrill E, Schilling A, Lakomkin N, Ahmed AK, Lo SF, Sciubba DM. Fenestrated pedicle screws for thoracolumbar instrumentation in patients with poor bone quality: Case series and systematic review of the literature. Clinical Neurology And Neurosurgery 2021, 206: 106675. PMID: 34020324, DOI: 10.1016/j.clineuro.2021.106675.Peer-Reviewed Original ResearchConceptsPulmonary cement embolismFenestrated pedicle screwsCement leakageBone qualityCement embolismInstrumented fusionHardware looseningOsteoporotic fracturesPedicle screwsSystematic reviewSymptomatic pulmonary cement embolismNon-augmented patientsSingle-surgeon seriesDegenerative spine diseaseHigh-quality evidencePoor bone qualityEndpoints of interestLow reported ratesPathologic fractureCase seriesSpine metastasesFenestrated screwsSpine diseasePRISMA guidelinesPatients
2020
Race and All-cause Mortality in Patients with a Primary Malignant or Nonmalignant Tumor of the Spinal Cord or Spinal Meninges
Elsamadicy A, Freedman I, Koo A, David W, Reeves B, Antonios J, Laurans M, Kolb L, Sciubba D. Race and All-cause Mortality in Patients with a Primary Malignant or Nonmalignant Tumor of the Spinal Cord or Spinal Meninges. Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_203.Peer-Reviewed Original ResearchCase Report: Suprasellar Pituitary Adenoma Presenting With Temporal Lobe Seizures
Hong CS, Gorrepati R, Kundishora AJ, Elsamadicy AA, Peter PR, Damisah EC, Manes RP, Omay SB. Case Report: Suprasellar Pituitary Adenoma Presenting With Temporal Lobe Seizures. Frontiers In Surgery 2020, 7: 598138. PMID: 33335912, PMCID: PMC7736041, DOI: 10.3389/fsurg.2020.598138.Peer-Reviewed Case Reports and Technical NotesPituitary macroadenomaTemporal lobeFurther seizure activityTemporal lobe seizuresYear old maleMass effectLeft temporal lobeSuprasellar pituitary adenomasEndocrine dysfunctionGeneralized seizuresSeizure activityPituitary pathologyPituitary adenomasMedical treatmentSeizuresEndoscopic endonasalMacroadenomasLobePatientsDysfunctionAdenomasSymptomsTumorsEndonasalPathologyPatient Risk Factors Associated with 30- and 90- Day Readmission after Ventriculoperitoneal Shunt Placement for Idiopathic Normal Pressure Hydrocephalus in Elderly Patients
Koo A, Elsamadicy A, Lin I, David W, Reeves B, Santarosa C, Cord B, Malhotra A, Kahle K, Matouk C. Patient Risk Factors Associated with 30- and 90- Day Readmission after Ventriculoperitoneal Shunt Placement for Idiopathic Normal Pressure Hydrocephalus in Elderly Patients. Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_202.Peer-Reviewed Original ResearchLaser interstitial thermal therapy (LITT) vs. bevacizumab for radiation necrosis in previously irradiated brain metastases
Sujijantarat N, Hong CS, Owusu KA, Elsamadicy AA, Antonios JP, Koo AB, Baehring JM, Chiang VL. Laser interstitial thermal therapy (LITT) vs. bevacizumab for radiation necrosis in previously irradiated brain metastases. Journal Of Neuro-Oncology 2020, 148: 641-649. PMID: 32602021, DOI: 10.1007/s11060-020-03570-0.Peer-Reviewed Original ResearchConceptsLaser interstitial thermal therapyLonger overall survivalRadiation necrosisInterstitial thermal therapyBrain metastasesOverall survivalMedian volume decreaseMedian volume increaseBrain metastasis patientsPre-treatment patient characteristicsRetrospective chart reviewResultsTwenty-five patientsPre-treatment factorsBevacizumab patientsChart reviewMetastasis patientsLocal recurrencePatient characteristicsTreatment optionsTreatment responseBevacizumabPatientsLesional volumeThermal therapyStatistical significanceRisk Factors for the Development of Post-Traumatic Hydrocephalus in Children
Elsamadicy AA, Koo AB, Lee V, David WB, Zogg CK, Kundishora AJ, Hong CS, DeSpenza T, Reeve BC, DiLuna M, Kahle KT. Risk Factors for the Development of Post-Traumatic Hydrocephalus in Children. World Neurosurgery 2020, 141: e105-e111. PMID: 32389871, PMCID: PMC7484270, DOI: 10.1016/j.wneu.2020.04.216.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryRisk factorsBrain injuryNationwide Emergency Department Sample databasePost-traumatic hydrocephalusClinical risk factorsDevelopment of hydrocephalusNeurologic complicationsRespiratory complicationsPediatric patientsHydrocephalus developmentNinth RevisionSubarachnoid hemorrhageEmergency departmentSecondary diagnosisPrimary diagnosisSubdural hemorrhageClinical ModificationInternational ClassificationHydrocephalusHemorrhagePatientsBaseline returnSample databaseAge 6Geographic Variation in Outcomes and Costs After Spinal Fusion for Adolescent Idiopathic Scoliosis
Koo AB, Elsamadicy AA, Kundishora AJ, David WB, Lee M, Hong CS, Lee V, Kahle KT, DiLuna M. Geographic Variation in Outcomes and Costs After Spinal Fusion for Adolescent Idiopathic Scoliosis. World Neurosurgery 2020, 136: e347-e354. PMID: 31917315, DOI: 10.1016/j.wneu.2019.12.175.Peer-Reviewed Original ResearchConceptsAdolescent idiopathic scoliosisLength of surgeryAdolescent patientsSpinal fusionIdiopathic scoliosisMultilevel posterior spinal fusionHealth care resource utilizationGreater complication ratePosterior spinal fusionPosterior spinal surgeryPostoperative complicationsComplication ratePrimary outcomeAIS patientsSpinal surgeryPatientsSurgeryAdmissionRegional variationComplicationsFurther studiesOutcomesCohortScoliosisTotal cost