A double blind randomized placebo controlled pilot study of single-dose preoperative modafinil for functional recovery after general anesthesia in patients with obstructive sleep apnea
Carr ZJ, Vells B, Wood BR, Lowery JD, Rogers AM, Kunselman AA, Karamchandani K, Vaida SJ. A double blind randomized placebo controlled pilot study of single-dose preoperative modafinil for functional recovery after general anesthesia in patients with obstructive sleep apnea. Medicine 2018, 97: e12585. PMID: 30278569, PMCID: PMC6181597, DOI: 10.1097/md.0000000000012585.Peer-Reviewed Original ResearchMeSH KeywordsAgedAirway ExtubationAnesthesia Recovery PeriodAnesthesia, GeneralBenzhydryl CompoundsBlood PressureDouble-Blind MethodFemaleHumansLength of StayMaleMiddle AgedModafinilPilot ProjectsPreoperative PeriodProof of Concept StudyRespiratory RateSleep Apnea, ObstructiveWakefulness-Promoting AgentsConceptsObstructive sleep apneaGeneral anesthesiaFunctional recoverySleep apneaPrimary outcomePACU lengthPsychomotor stimulantsPost-anesthesia care unit lengthDiagnosis of OSAIntraoperative bispectral index valuePlacebo-controlled pilot studyPost-anesthesia care unitPilot studyPostoperative pain scoresPost-anesthesia recoveryBispectral index valuesModafinil groupPain scoresSurgical populationNarcotic consumptionArterial pressureDaytime somnolenceCare unitAnesthesiaVolatile anesthetics