2019
In a Model of Neuroinflammation Designed to Mimic Delirium, Quetiapine Reduces Cortisol Secretion and Preserves Reversal Learning in the Attentional Set Shifting Task
Carr ZJ, Miller L, Ruiz-Velasco V, Kunselman AR, Karamchandani K. In a Model of Neuroinflammation Designed to Mimic Delirium, Quetiapine Reduces Cortisol Secretion and Preserves Reversal Learning in the Attentional Set Shifting Task. Journal Of Neuroimmune Pharmacology 2019, 14: 383-390. PMID: 31119596, DOI: 10.1007/s11481-019-09857-y.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntipsychotic AgentsAppetitive BehaviorAttentionDeliriumDisease Models, AnimalDrug Evaluation, PreclinicalExecutive FunctionFemaleFrontal LobeHydrocortisoneInflammationLipopolysaccharidesQuetiapine FumarateRandom AllocationRatsRats, Sprague-DawleyReversal LearningRewardSet, PsychologyTumor Necrosis Factor-alphaConceptsCortisol levelsTumor necrosis factor-alpha levelsNecrosis factor-alpha levelsSprague-Dawley female ratsBeneficial effectsModel of neuroinflammationTreatment of deliriumTNF-α levelsAtypical antipsychotic medicationsEffects of quetiapineDawley female ratsIntraperitoneal placeboPlacebo groupQuetiapine groupNeuroinflammatory modelReversal learningAntipsychotic medicationPre-clinical validationCortisol secretionSerum cortisolFemale ratsPlaceboCortisol productionRodent modelsQuetiapine
2018
Continuation of atypical antipsychotic medications in critically ill patients discharged from the hospital: a single-center retrospective analysis
Karamchandani K, Schoaps RS, Bonavia A, Prasad A, Quintili A, Lehman EB, Carr ZJ. Continuation of atypical antipsychotic medications in critically ill patients discharged from the hospital: a single-center retrospective analysis. Therapeutic Advances In Drug Safety 2018, 10: 2042098618809933. PMID: 31019677, PMCID: PMC6463330, DOI: 10.1177/2042098618809933.Peer-Reviewed Original ResearchIntensive care unitAtypical antipsychoticsHospital dischargeMale sexRisk factorsSingle-center retrospective chart analysisSingle-center retrospective analysisTertiary care academic medical centerAdult intensive care unitsRisk of continuationSignificant adverse eventsRetrospective chart analysisAssociated risk factorsIntensive care settingAtypical antipsychotic medicationsYears of ageAcademic medical centerLong-term riskLong-term useAAP therapyCause mortalityAdult patientsAdverse eventsOlder patientsICU patients