2023
IRX5 promotes DNA damage repair and activation of hair follicle stem cells
Chen J, Wiedemann J, Nguyen L, Lin Z, Tahir M, Hui C, Plikus M, Andersen B. IRX5 promotes DNA damage repair and activation of hair follicle stem cells. Stem Cell Reports 2023, 18: 1227-1243. PMID: 37084727, PMCID: PMC10202659, DOI: 10.1016/j.stemcr.2023.03.013.Peer-Reviewed Original ResearchConceptsDNA damage repairDamage repairStem cellsDNA damageDNA damage repair genesCell cycle progressionHair follicle stem cellsEpidermal stem cellsFollicle stem cellsIrx genesChromatin regionsHFSC proliferationHFSC activationInterfollicular epidermal stem cellsDownstream targetsCycle progressionIRX5Molecular mechanismsRepair genesFGF18 expressionAnagen onsetBRCA1 expressionQuiescent phenotypeGenesPromoter
2020
Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states
Lin Z, Jin S, Chen J, Li Z, Lin Z, Tang L, Nie Q, Andersen B. Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states. Nature Communications 2020, 11: 5434. PMID: 33116143, PMCID: PMC7595230, DOI: 10.1038/s41467-020-19234-6.Peer-Reviewed Original ResearchConceptsCell statesRNA velocity analysisSingle-cell RNA-seqTerminal differentiation genesStem cell stateInterfollicular epidermisStem cellsInterfollicular epidermal differentiationStem cell expansionDifferentiation genesRNA-seqCommitment pointTerminal differentiationGRHL3Epidermal differentiationCell expansionDifferentiationCellsTransition cellsWntGenesHomeostasis