Genomic Correlates of Unfavorable Outcome in Locally Advanced Cervical Cancer Treated with Neoadjuvant Chemoradiation
Wei Y, Wei C, Chen L, Liu N, Ou Q, Yin J, Pang J, Fang Z, Wu X, Wang X, Mu D, Shao Y, Yu J, Yuan S. Genomic Correlates of Unfavorable Outcome in Locally Advanced Cervical Cancer Treated with Neoadjuvant Chemoradiation. Cancer Research And Treatment 2022, 54: 1209-1218. PMID: 35038823, PMCID: PMC9582489, DOI: 10.4143/crt.2021.963.Peer-Reviewed Original ResearchConceptsDisease-free survivalAdvanced cervical cancerAdvanced cervical cancer patientsCervical cancer patientsTumor biopsy samplesCervical cancerNeoadjuvant chemoradiationPathologic responseCancer patientsKEAP1 mutationsHigh tumor mutation burdenNeoadjuvant chemoradiation treatmentPoor pathologic responseEarly disease recurrenceTumor mutation burdenGenetic alterationsDNA damage repair genesOperability rateChemoradiation treatmentNeoadjuvant therapyNeoadjuvant treatmentRadical hysterectomyCancer Genome AtlasDisease recurrenceDisease relapse