Inhibition of Signal Transducer and Activator of Transcription 3 and Cyclooxygenase-2 Is Involved in Radiosensitization of Cepharanthine in HeLa Cells
Fang Z, Li Y, Chen Z, Wang J, Zhu L. Inhibition of Signal Transducer and Activator of Transcription 3 and Cyclooxygenase-2 Is Involved in Radiosensitization of Cepharanthine in HeLa Cells. International Journal Of Gynecological Cancer 2013, 23: 608. PMID: 23466568, DOI: 10.1097/igc.0b013e31828a05fd.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisBenzylisoquinolinesCyclooxygenase 2 InhibitorsHeLa CellsHumansRadiation ToleranceRadiation-Sensitizing AgentsSignal TransductionSTAT3 Transcription FactorConceptsHeLa cellsSignal transducerTranscription 3C-MycSTAT3 target genesCell cycle regulators c-MycBcl-2Antiapoptotic Bcl-2Target genesWestern blot analysisHeLa cell lineApoptosis inductionBlot analysisNude mouse xenograftsCell linesReduced expressionSTAT3Apoptosis analysisMouse xenograftsSignificant radiosensitizationIR treatmentClonogenic assayActivatorCellsCytotoxic effects