2022
Genomic Correlates of Unfavorable Outcome in Locally Advanced Cervical Cancer Treated with Neoadjuvant Chemoradiation
Wei Y, Wei C, Chen L, Liu N, Ou Q, Yin J, Pang J, Fang Z, Wu X, Wang X, Mu D, Shao Y, Yu J, Yuan S. Genomic Correlates of Unfavorable Outcome in Locally Advanced Cervical Cancer Treated with Neoadjuvant Chemoradiation. Cancer Research And Treatment 2022, 54: 1209-1218. PMID: 35038823, PMCID: PMC9582489, DOI: 10.4143/crt.2021.963.Peer-Reviewed Original ResearchConceptsDisease-free survivalAdvanced cervical cancerAdvanced cervical cancer patientsCervical cancer patientsTumor biopsy samplesCervical cancerNeoadjuvant chemoradiationPathologic responseCancer patientsKEAP1 mutationsHigh tumor mutation burdenNeoadjuvant chemoradiation treatmentPoor pathologic responseEarly disease recurrenceTumor mutation burdenGenetic alterationsDNA damage repair genesOperability rateChemoradiation treatmentNeoadjuvant therapyNeoadjuvant treatmentRadical hysterectomyCancer Genome AtlasDisease recurrenceDisease relapse
2021
Genomic profiling of biliary tract cancers to reveal clinically actionable genes and therapeutic biomarkers.
Shao Y, Ou Q, Fang Z, Liu R, Bao H, Wu X. Genomic profiling of biliary tract cancers to reveal clinically actionable genes and therapeutic biomarkers. Journal Of Clinical Oncology 2021, 39: e16187-e16187. DOI: 10.1200/jco.2021.39.15_suppl.e16187.Peer-Reviewed Original ResearchTumor mutation burdenMicrosatellite instability statusGallbladder cancerTelomeric allelic imbalanceBTC patientsDistal cholangiocarcinomaPerihilar cholangiocarcinomaTract cancerIntrahepatic cholangiocarcinomaCancer patientsBiliary tract cancer patientsHigh tumor mutation burdenDNA damage repair pathway genesImpaired mismatch repairBiliary tract cancerHomologous recombination repairPoly (ADP-ribose) polymerase (PARP) inhibitorsDDR gene alterationsTumor tissue samplesMismatch repairBase excision repair genesBTC subtypesHRR mutationsClinical outcomesPoor prognosis