Genomic profiling of biliary tract cancers to reveal clinically actionable genes and therapeutic biomarkers.
Shao Y, Ou Q, Fang Z, Liu R, Bao H, Wu X. Genomic profiling of biliary tract cancers to reveal clinically actionable genes and therapeutic biomarkers. Journal Of Clinical Oncology 2021, 39: e16187-e16187. DOI: 10.1200/jco.2021.39.15_suppl.e16187.Peer-Reviewed Original ResearchTumor mutation burdenMicrosatellite instability statusGallbladder cancerTelomeric allelic imbalanceBTC patientsDistal cholangiocarcinomaPerihilar cholangiocarcinomaTract cancerIntrahepatic cholangiocarcinomaCancer patientsBiliary tract cancer patientsHigh tumor mutation burdenDNA damage repair pathway genesImpaired mismatch repairBiliary tract cancerHomologous recombination repairPoly (ADP-ribose) polymerase (PARP) inhibitorsDDR gene alterationsTumor tissue samplesMismatch repairBase excision repair genesBTC subtypesHRR mutationsClinical outcomesPoor prognosis