2024
Intrauterine chromium exposure and cognitive developmental delay: The modifying effect of genetic predisposition
Jia Z, Zhang H, Lv Y, Yu L, Cui Y, Zhang L, Yang C, Liu H, Zheng T, Xia W, Xu S, Li Y. Intrauterine chromium exposure and cognitive developmental delay: The modifying effect of genetic predisposition. The Science Of The Total Environment 2024, 946: 174350. PMID: 38960203, DOI: 10.1016/j.scitotenv.2024.174350.Peer-Reviewed Original ResearchRisk due to interactionCognitive developmental delayGenetic riskSynergy indexGenetic factorsExcess risk due to interactionDevelopmental delayBayley Scales of Infant DevelopmentProportion due to interactionPolygenic risk scoresHigh-risk factorsEffects of genetic predispositionDose-response relationshipMother-child pairsGenetic backgroundBayley ScalesGenetic predispositionIncreased riskRisk scoreCr exposureLogistic regressionInfant developmentPlasma Cr concentrationIntrauterineAdditive interaction
2023
A nested case-control study of serum zinc and incident diabetes among Chinese adults: Effect modifications and mediation analysis
Yang J, Cheng Z, Zhang D, Zheng T, Yin C, Liu S, Zhang L, Wang Z, Wang Y, Chen R, Dou Q, Bai Y. A nested case-control study of serum zinc and incident diabetes among Chinese adults: Effect modifications and mediation analysis. The Science Of The Total Environment 2023, 910: 168678. PMID: 37981151, DOI: 10.1016/j.scitotenv.2023.168678.Peer-Reviewed Original ResearchConceptsSerum zinc levelsRisk of diabetesCase-control studySerum zincDiabetes riskEffect modificationZinc levelsMediation proportionBaseline serum zinc concentrationPositive linear dose-response relationshipConditional logistic regression modelsHistory of hypertensionProspective population studyBody mass indexCoronary heart diseasePotential effect modificationSerum zinc concentrationLinear dose-response relationshipPopulation studiesDose-response relationshipLogistic regression modelsIncident diabetesHighest quartileMass indexFourth quartile