Intrauterine chromium exposure and cognitive developmental delay: The modifying effect of genetic predisposition
Jia Z, Zhang H, Lv Y, Yu L, Cui Y, Zhang L, Yang C, Liu H, Zheng T, Xia W, Xu S, Li Y. Intrauterine chromium exposure and cognitive developmental delay: The modifying effect of genetic predisposition. The Science Of The Total Environment 2024, 946: 174350. PMID: 38960203, DOI: 10.1016/j.scitotenv.2024.174350.Peer-Reviewed Original ResearchRisk due to interactionCognitive developmental delayGenetic riskSynergy indexGenetic factorsExcess risk due to interactionDevelopmental delayBayley Scales of Infant DevelopmentProportion due to interactionPolygenic risk scoresHigh-risk factorsEffects of genetic predispositionDose-response relationshipMother-child pairsGenetic backgroundBayley ScalesGenetic predispositionIncreased riskRisk scoreCr exposureLogistic regressionInfant developmentPlasma Cr concentrationIntrauterineAdditive interaction