VEGF Receptor 2 Endocytic Trafficking Regulates Arterial Morphogenesis
Lanahan AA, Hermans K, Claes F, Kerley-Hamilton JS, Zhuang ZW, Giordano FJ, Carmeliet P, Simons M. VEGF Receptor 2 Endocytic Trafficking Regulates Arterial Morphogenesis. Developmental Cell 2010, 18: 713-724. PMID: 20434959, PMCID: PMC2875289, DOI: 10.1016/j.devcel.2010.02.016.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsArteriesCarrier ProteinsCell MembraneEndocytosisEndothelium, VascularGene SilencingMiceMice, KnockoutMorphogenesisMyosin Heavy ChainsNeuropeptidesPhosphorylationVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2ZebrafishConceptsArterial morphogenesisSelective dephosphorylationPlasma membraneIntracellular traffickingKey growth factorsNull phenotypeMyosin VIMolecular eventsMorphogenesisVEGFR2 activationTraffickingIntracellular sitesKey eventsPTP1BNull miceKnockdownImpaired VEGFGrowth factorVEGFR2ActivationDephosphorylationEndosomesVEGFPhosphorylationSitesERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish
Ren B, Deng Y, Mukhopadhyay A, Lanahan AA, Zhuang ZW, Moodie KL, Mulligan-Kehoe MJ, Byzova TV, Peterson RT, Simons M. ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish. Journal Of Clinical Investigation 2010, 120: 1217-1228. PMID: 20237411, PMCID: PMC2846043, DOI: 10.1172/jci39837.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsArteriesCarrier ProteinsMaleMiceMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3MorphogenesisNeovascularization, PhysiologicNeuropeptidesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2ZebrafishZebrafish Proteins