2021
Detection of differentially abundant cell subpopulations in scRNA-seq data
Zhao J, Jaffe A, Li H, Lindenbaum O, Sefik E, Jackson R, Cheng X, Flavell RA, Kluger Y. Detection of differentially abundant cell subpopulations in scRNA-seq data. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2100293118. PMID: 34001664, PMCID: PMC8179149, DOI: 10.1073/pnas.2100293118.Peer-Reviewed Original ResearchMeSH KeywordsAgingB-LymphocytesBrainCell LineageCOVID-19CytokinesDatasets as TopicDendritic CellsGene Expression ProfilingGene Expression RegulationHigh-Throughput Nucleotide SequencingHumansMelanomaMonocytesPhenotypeRNA, Small CytoplasmicSARS-CoV-2Severity of Illness IndexSingle-Cell AnalysisSkin NeoplasmsT-LymphocytesTranscriptomeConceptsDA subpopulationsIll COVID-19 patientsImmune checkpoint therapyCOVID-19 patientsSingle-cell RNA sequencing analysisCheckpoint therapyBrain tissueCell subpopulationsRNA sequencing analysisTime pointsSubpopulationsDiseased individualsDistinct phenotypesOriginal studyCell typesAbundant subpopulationSequencing analysisCellsDA measuresPhenotypeImportant differencesNonrespondersPatientsTherapy
2003
Spectral Biclustering of Microarray Data: Coclustering Genes and Conditions
Kluger Y, Basri R, Chang JT, Gerstein M. Spectral Biclustering of Microarray Data: Coclustering Genes and Conditions. Genome Research 2003, 13: 703-716. PMID: 12671006, PMCID: PMC430175, DOI: 10.1101/gr.648603.Peer-Reviewed Original ResearchBreast NeoplasmsCentral Nervous System NeoplasmsCerebellar NeoplasmsDatabases, GeneticGene Expression ProfilingGene Expression Regulation, NeoplasticGenes, NeoplasmGliomaHumansLeukemia, Lymphocytic, Chronic, B-CellLymphoma, B-CellLymphoma, FollicularLymphoma, Large B-Cell, DiffuseMedulloblastomaNeoplasms, Germ Cell and EmbryonalOligonucleotide Array Sequence AnalysisPhenotypeReference ValuesTumor Cells, Cultured