GAD65 tunes the functions of Best1 as a GABA receptor and a neurotransmitter conducting channel
Wang J, Owji A, Kittredge A, Clark Z, Zhang Y, Yang T. GAD65 tunes the functions of Best1 as a GABA receptor and a neurotransmitter conducting channel. Nature Communications 2024, 15: 8051. PMID: 39277606, PMCID: PMC11401937, DOI: 10.1038/s41467-024-52039-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBestrophinsGamma-Aminobutyric AcidGlutamate DecarboxylaseGlutamic AcidHEK293 CellsHumansNeurotransmitter AgentsProtein BindingReceptors, GABA-ARetinal Pigment EpitheliumConceptsCl- currentsRetinal pigment epithelial cellsIsoform of glutamic acid decarboxylasePigment epithelial cellsGlutamic acid decarboxylaseG-aminobutyric acidBestrophin-1BEST1GABA receptorsTransport metabolonEpithelial cellsGAD65Glutamate metabolizing enzymesAcid decarboxylaseGAD67Bestrophin channelsGABAExtracellular sitesNo effectAnion channelMetabolic enzymesPhysiological roleGlutamateCellsBestrophin