2016
Isoform Switch of TET1 Regulates DNA Demethylation and Mouse Development
Zhang W, Xia W, Wang Q, Towers AJ, Chen J, Gao R, Zhang Y, Yen CA, Lee AY, Li Y, Zhou C, Liu K, Zhang J, Gu TP, Chen X, Chang Z, Leung D, Gao S, Jiang YH, Xie W. Isoform Switch of TET1 Regulates DNA Demethylation and Mouse Development. Molecular Cell 2016, 64: 1062-1073. PMID: 27916660, DOI: 10.1016/j.molcel.2016.10.030.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesChromatinCpG IslandsDNA-Binding ProteinsEmbryo, MammalianGene Expression Regulation, DevelopmentalGenomic ImprintingMaleMiceMouse Embryonic Stem CellsOvumPromoter Regions, GeneticProtein BindingProtein Interaction Domains and MotifsProtein IsoformsProto-Oncogene ProteinsSpermatozoaConceptsPrimordial germ cellsEmbryonic stem cellsCpG islandsChromatin bindingDNA demethylationMouse developmentDNA-binding modulesCXXC domainTET proteinsEarly embryosSomatic cellsN-terminusDevelopmental defectsShort isoformExclusive expressionTET1Germ cellsIsoform switchStem cellsDemethylationIsoformsCellsBindingImportant roleTerminus
2011
E6AP is required for replicative and oncogene-induced senescence in mouse embryo fibroblasts
Levav-Cohen Y, Wolyniec K, Alsheich-Bartok O, Chan A, Woods S, Jiang Y, Haupt S, Haupt Y. E6AP is required for replicative and oncogene-induced senescence in mouse embryo fibroblasts. Oncogene 2011, 31: 2199-2209. PMID: 21927031, DOI: 10.1038/onc.2011.402.Peer-Reviewed Original ResearchConceptsMouse embryo fibroblastsOncogene-induced senescenceCellular responsesEmbryo fibroblastsCellular stress responseRas-induced senescenceE3 ubiquitin ligaseStress-induced accumulationRole of E6APUbiquitin ligaseProtein regulatorsTissue homeostasisReplicative senescenceCellular senescenceCell cycleStress responseImportant regulatorSenescenceStress conditionsE6APIndependent growthEnhanced growthEnhanced proliferationReplicativeRegulator