2021
BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology
Zhang L, Qian Y, Li J, Zhou X, Xu H, Yan J, Xiang J, Yuan X, Sun B, Sisodia SS, Jiang YH, Cao X, Jing N, Lin A. BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology. IScience 2021, 24: 102942. PMID: 34430820, PMCID: PMC8369003, DOI: 10.1016/j.isci.2021.102942.Peer-Reviewed Original ResearchNeuronal apoptosisAlzheimer's diseaseMicroglial phagocytosisMicroglial NLRP3 inflammasome activationDisease pathologyCommon progressive neurodegenerative diseaseProgressive neurodegenerative diseaseAlzheimer's disease pathologyNLRP3 inflammasome activationPotential therapeutic targetNeuroinflammatory microgliaAD miceAβ clearanceAD pathologyBad pro-apoptotic activityAD patientsInflammasome activationTherapeutic targetMemory deficitsPro-apoptotic proteinsNeuroinflammationNeurodegenerative diseasesSpatial learningInactivation of BadPro-apoptotic activity
2020
The role of Hipk2-p53 pathways in arsenic-induced autistic behaviors: A translational study from rats to humans
Zhou H, Lin Y, Zhao W, Teng Y, Cui Y, Wang T, Li C, Jiang YH, Zhang JJ, Wang Y. The role of Hipk2-p53 pathways in arsenic-induced autistic behaviors: A translational study from rats to humans. Environmental Pollution 2020, 267: 115568. PMID: 33254717, DOI: 10.1016/j.envpol.2020.115568.Peer-Reviewed Original ResearchConceptsCase-control studySerum levelsArsenic exposureHealthy controlsNeuronal apoptosisFrontal cortexAge-matched healthy controlsGestational arsenic exposureHuman case-control studiesASD developmentHigher serum levelsAutistic behaviorASD childrenDose-dependent mannerAutism spectrum disorderPotential mediating pathwaysRat modelRat pupsKey molecular changesImmunohistochemistry analysisTranslational studiesWestern blottingMolecular changesTranslational strategiesMediating pathways