2013
Epigenetic Therapies in Neurological Diseases
Huang H, Philpot B, Jiang Y. Epigenetic Therapies in Neurological Diseases. Epigenetics And Human Health 2013, 167-193. DOI: 10.1007/978-3-642-36827-1_8.Peer-Reviewed Original ResearchCentral nervous system disordersNervous system disordersCentral nervous systemHuman clinical trialsEpigenetic therapyPeripheral disordersClinical trialsHistone deacetylation inhibitorsSystem disordersTherapeutic strategiesPsychiatric disordersNervous systemUS FoodDrug AdministrationNeurological diseasesTherapeutic interventionsDisease pathophysiologyClinical useTherapyDisordersDeacetylation inhibitorsSuitable targetEpigenetic abnormalitiesEpigenetic modifiersCurrent understanding
2004
A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A
Jiang Y, Sahoo T, Michaelis RC, Bercovich D, Bressler J, Kashork CD, Liu Q, Shaffer LG, Schroer RJ, Stockton DW, Spielman RS, Stevenson RE, Beaudet AL. A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A. American Journal Of Medical Genetics Part A 2004, 131A: 1-10. PMID: 15389703, DOI: 10.1002/ajmg.a.30297.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAutistic DisorderBlotting, SouthernBlotting, WesternBrainChromosome AberrationsChromosomes, Human, Pair 15Deoxyribonuclease BamHIDeoxyribonuclease HpaIIDNADNA MethylationFemaleGene DuplicationHumansIn Situ Hybridization, FluorescenceMaleModels, GeneticMutationPedigreeUbiquitin-Protein LigasesConceptsOligogenic inheritanceComplex disease traitsGenome-wide studiesAbnormal DNA methylationE6-AP proteinDe novoGenetic modelsRole of UBE3AUbiquitin ligaseDNA methylationEpigenetic abnormalitiesDisease traitsAutism brainPaternal duplicationChromosome 15qUBE3AGenetic contributionRegion downstreamGenesOligogenic modelInheritanceProteinNovoLigaseBrain samples