2023
Novel epigenetic molecular therapies for imprinting disorders
Wang S, Jiang Y. Novel epigenetic molecular therapies for imprinting disorders. Molecular Psychiatry 2023, 28: 3182-3193. PMID: 37626134, PMCID: PMC10618104, DOI: 10.1038/s41380-023-02208-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsActive alleleImprinting disordersMolecular mechanismsGenome editing approachesEpigenetic-based therapiesUnique molecular mechanismGenomic imprinting disordersImprinted genesGenome editingMolecular approachesEditing approachesInactive allelesNew therapeutic strategiesAllelesSmall moleculesMolecular therapyTherapeutic strategies
2018
CRISPR/Cas9-induced shank3b mutant zebrafish display autism-like behaviors
Liu CX, Li CY, Hu CC, Wang Y, Lin J, Jiang YH, Li Q, Xu X. CRISPR/Cas9-induced shank3b mutant zebrafish display autism-like behaviors. Molecular Autism 2018, 9: 23. PMID: 29619162, PMCID: PMC5879542, DOI: 10.1186/s13229-018-0204-x.Peer-Reviewed Original ResearchConceptsMutant zebrafishMutant zebrafish modelGenome editing techniquesGene editing approachesZebrafish genomeOrthologous genesAttractive organismGenomic studiesCRISPR/Cas9 gene editing approachGenetic manipulationZebrafish modelCRISPR/ZebrafishMolecular mechanismsEditing approachesAdult stageFunction mutationsMolecular analysisEditing techniquesMolecular changesAutism-like behaviorsEarly developmentSwimming behaviorPresynaptic synaptophysinMorphological measurements