2024
Sex‐specific topological structure associated with dementia via latent space estimation
Wang S, Wang Y, Xu F, Tian X, Fredericks C, Shen L, Zhao Y, Initiative F. Sex‐specific topological structure associated with dementia via latent space estimation. Alzheimer's & Dementia 2024 PMID: 39530632, DOI: 10.1002/alz.14266.Peer-Reviewed Original ResearchCollaborative Survival Analysis on Predicting Alzheimer’s Disease Progression
Xu W, Wang S, Shen L, Zhao Y. Collaborative Survival Analysis on Predicting Alzheimer’s Disease Progression. Statistics In Biosciences 2024, 1-24. DOI: 10.1007/s12561-024-09459-0.Peer-Reviewed Original ResearchAlzheimer's diseaseGenes associated with neuronal developmentAlzheimer's Disease Neuroimaging InitiativeGenetic dataAlzheimer's disease progressionGenetic variationPhenotypic varianceAD progressionGenetic featuresNeuronal developmentGenetic biomarkersAlzheimerADNI databaseMild cognitive impairmentSNPsCanonical correlation analysisGenesStructural MRI scansCombination of brain imagingBrain imagingGeneticsProgression of mild cognitive impairmentAD literatureTime-to-event outcomesTime-to-event predictionsEstablishing group-level brain structural connectivity incorporating anatomical knowledge under latent space modeling
Wang S, Wang Y, Xu F, Shen L, Zhao Y, Initiative A. Establishing group-level brain structural connectivity incorporating anatomical knowledge under latent space modeling. Medical Image Analysis 2024, 99: 103309. PMID: 39243600, DOI: 10.1016/j.media.2024.103309.Peer-Reviewed Original ResearchBrain structural connectivityBrain connectivityStructural connectivityBrain connectivity matricesDiffusion MRITopological propertiesGenerative network modelsWhite matter fiber tractsAttributes of nodesConnectivity estimatesBrain networksGroup-level connectivityConnectivity matrixBrain regionsConnectivity architectureKnowledge of nodesAlzheimer's diseaseLatent space modelAnatomical informationGroup-level effectsImprove biological interpretationExtensive simulationsNetwork modelABC modelMedial amygdalar tau is associated with mood symptoms in preclinical Alzheimer’s disease
Li J, Tun S, Ficek-Tani B, Xu W, Wang S, Horien C, Toyonaga T, Nuli S, Zeiss C, Powers A, Zhao Y, Mormino E, Fredericks C. Medial amygdalar tau is associated with mood symptoms in preclinical Alzheimer’s disease. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39059466, DOI: 10.1016/j.bpsc.2024.07.012.Peer-Reviewed Original ResearchAssociated with mood symptomsMood symptomsAmyloid-positive individualsMedial amygdalaSeed-based functional connectivity analysisAssociated with anxiety symptomsSelf-reported mood symptomsPost hoc correlation analysisAlzheimer's diseaseFunctional connectivity analysisPreclinical Alzheimer's diseaseTau bindingOrbitofrontal cortexTau depositionAmygdalar connectivityEmotional processingAnxiety symptomsRetrosplenial cortexBetween-group differencesAmygdalaFunctional connectivityLateral amygdalaConnectivity analysisDepression scoresNeuropsychiatric symptomsKnowledge-guided learning methods for integrative analysis of multi-omics data
Li W, Ballard J, Zhao Y, Long Q. Knowledge-guided learning methods for integrative analysis of multi-omics data. Computational And Structural Biotechnology Journal 2024, 23: 1945-1950. PMID: 38736693, PMCID: PMC11087912, DOI: 10.1016/j.csbj.2024.04.053.Peer-Reviewed Original ResearchAnalysis of multi-omics dataIntegrative analysis of multi-omics dataMulti-omics dataMulti-omics data integration methodBiological knowledgeMulti-omics data integrationMulti-omics data analysisMulti-omics studiesIntegrated analysisFunctional genomicsFunctional proteomicsData integration methodsComplex diseasesMolecular mechanismsAlzheimer's diseaseComprehensive insightGenomeProteomicsGenesAnalytical challengesPathwayAlzheimer
2021
Polygenic mediation analysis of Alzheimer's disease implicated intermediate amyloid imaging phenotypes.
Yingxuan E, Yao X, Liu K, Risacher SL, Saykin AJ, Long Q, Zhao Y, Shen L. Polygenic mediation analysis of Alzheimer's disease implicated intermediate amyloid imaging phenotypes. AMIA Annual Symposium Proceedings 2021, 2020: 422-431. PMID: 33936415, PMCID: PMC8075527.Peer-Reviewed Original Research