The 11S Proteasome Subunit PSME3 Is a Positive Feedforward Regulator of NF-κB and Important for Host Defense against Bacterial Pathogens
Sun J, Luan Y, Xiang D, Tan X, Chen H, Deng Q, Zhang J, Chen M, Huang H, Wang W, Niu T, Li W, Peng H, Li S, Li L, Tang W, Li X, Wu D, Wang P. The 11S Proteasome Subunit PSME3 Is a Positive Feedforward Regulator of NF-κB and Important for Host Defense against Bacterial Pathogens. Cell Reports 2016, 14: 737-749. PMID: 26776519, PMCID: PMC4740229, DOI: 10.1016/j.celrep.2015.12.069.Peer-Reviewed Original ResearchConceptsToll-like receptorsNF-κB pathwayBacterial infectionsHost defenseNF-κB regulationNF-κBNF-κB transcriptional activityNF-κB-mediated transcriptionBacterial burdenImmune responseTranscriptional activityInnate immunityInfectionHematopoietic cellsBacterial pathogensFeedforward mechanismPSME3MacrophagesHost tissuesNegative regulatorPathwayImmunityReceptors