2022
Chronic intermittent hypoxia induces gut microbial dysbiosis and infers metabolic dysfunction in mice
Zhang Y, Luo H, Niu Y, Yang X, Li Z, Wang K, Bi H, Pang X. Chronic intermittent hypoxia induces gut microbial dysbiosis and infers metabolic dysfunction in mice. Sleep Medicine 2022, 91: 84-92. PMID: 35286865, DOI: 10.1016/j.sleep.2022.02.003.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaCo-abundance groupsChronic intermittent hypoxiaIntermittent hypoxiaSystemic inflammationGut microbiotaGut microbiomeElevated systemic inflammationAdverse metabolic outcomesGut microbial dysbiosisMale C57BL/6 micePrevalent sleep disorderFatty acid metabolismIH miceIH exposureMetabolic riskSleep apneaC57BL/6 miceMicrobial dysbiosisComposition of microbiotaMetabolic outcomesIntestinal microbial communityMetabolism disordersMetabolic dysfunctionSleep disorders
2021
Ketogenic Diets Induced Glucose Intolerance and Lipid Accumulation in Mice with Alterations in Gut Microbiota and Metabolites
Li Y, Yang X, Zhang J, Jiang T, Zhang Z, Wang Z, Gong M, Zhao L, Zhang C. Ketogenic Diets Induced Glucose Intolerance and Lipid Accumulation in Mice with Alterations in Gut Microbiota and Metabolites. MBio 2021, 12: 10.1128/mbio.03601-20. PMID: 33785628, PMCID: PMC8092315, DOI: 10.1128/mbio.03601-20.Peer-Reviewed Original ResearchConceptsKetogenic dietGut microbiotaProportion of fatLipid metabolismGlucose intoleranceInsulin resistanceFat accumulationMouse trialsNeurodegenerative diseasesLipid accumulationMore fat accumulationInduced glucose intoleranceLipid metabolism disordersAffected lipid metabolismMetabolism disordersMetabolic disordersGlucose homeostasisGlucose metabolismSource of fatHuman studiesHigh fatTreatment of diseasesMiceBeneficial effectsWeight loss
2017
Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice
Yang X, Wang Q, Pang Z, Pan M, Zhang W. Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice. Pharmaceutical Biology 2017, 55: 1207-1214. PMID: 28248545, PMCID: PMC6130443, DOI: 10.1080/13880209.2016.1278454.Peer-Reviewed Original ResearchConceptsHigh-fat dietAdipose tissueC57BL/6 miceFat dietFSH treatmentBody weightMRNA expressionAdipose tissue inflammationMolecular targetsLipid metabolism disordersObese mouse modelHepatic triglyceride accumulationEffect of FSHTNFα mRNA expressionPPARα mRNA expressionRegulation of PPARγBody weight gainPPARγ protein levelsPotential molecular targetsPPARα gene expressionFSH administrationMacrophage infiltrationTissue inflammationCholesterol levelsMetabolism disorders