Genetically Obese Human Gut Microbiota Induces Liver Steatosis in Germ-Free Mice Fed on Normal Diet
Wang R, Li H, Yang X, Xue X, Deng L, Shen J, Zhang M, Zhao L, Zhang C. Genetically Obese Human Gut Microbiota Induces Liver Steatosis in Germ-Free Mice Fed on Normal Diet. Frontiers In Microbiology 2018, 9: 1602. PMID: 30079055, PMCID: PMC6062601, DOI: 10.3389/fmicb.2018.01602.Peer-Reviewed Original ResearchHepatic transcriptional profilePreM groupGut microbiotaLiver steatosisNon-alcoholic fatty liver diseaseDietary weight loss programObesity-associated gut microbiotaLipid metabolismPeroxisome proliferator-activated receptor alphaProliferator-activated receptor alphaDysbiotic gut microbiotaLiver macrovesicular steatosisFatty liver diseaseNormal chow dietWeight loss programC57BL/6J male miceNormal hepatic physiologyObese human donorsLiver diseaseChow dietLoss programMice fedHuman gut microbiotaMacrovesicular steatosisMetabolic deterioration