2022
A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease
Cheng R, Wang L, Le S, Yang Y, Zhao C, Zhang X, Yang X, Xu T, Xu L, Wiklund P, Ge J, Lu D, Zhang C, Chen L, Cheng S. A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease. Nature Communications 2022, 13: 2555. PMID: 35538056, PMCID: PMC9091228, DOI: 10.1038/s41467-022-29968-0.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFatty liver diseaseDiet interventionPrimary outcomeLiver diseaseTreatment of NAFLDThird primary outcomeTRIAL REGISTRATION NUMBERLiver fat contentCombined aerobic exerciseEffects of interventionsLiver fatAerobic exerciseGlucose metabolismGut microbiotaRegistration numberLarger sample sizeMicrobiota compositionExploratory adPatientsAdverse effectsInterventionIntervention strategiesPrediabetesExercise
2020
Active phase prebiotic feeding alters gut microbiota, induces weight-independent alleviation of hepatic steatosis and serum cholesterol in high-fat diet-fed mice
Ghosh S, Yang X, Wang L, Zhang C, Zhao L. Active phase prebiotic feeding alters gut microbiota, induces weight-independent alleviation of hepatic steatosis and serum cholesterol in high-fat diet-fed mice. Computational And Structural Biotechnology Journal 2020, 19: 448-458. PMID: 33510856, PMCID: PMC7806547, DOI: 10.1016/j.csbj.2020.12.011.Peer-Reviewed Original ResearchNon-alcoholic fatty liver diseaseSerum cholesterolGut microbiotaPrebiotic feedingLiver steatosisHepatic steatosisHigh fat diet fed miceHigh-fat diet-fed miceAlters gut microbiotaDiet fed miceFatty liver diseaseDiet-fed miceCholesterol-lowering effectGut microbiota structureImpact of prebioticsIncreased SCFA productionPrebiotic intakeLiver diseaseFed micePrebiotic consumptionDay 7SteatosisBeneficial effectsWeight lossUnrestricted feeding
2018
Genetically Obese Human Gut Microbiota Induces Liver Steatosis in Germ-Free Mice Fed on Normal Diet
Wang R, Li H, Yang X, Xue X, Deng L, Shen J, Zhang M, Zhao L, Zhang C. Genetically Obese Human Gut Microbiota Induces Liver Steatosis in Germ-Free Mice Fed on Normal Diet. Frontiers In Microbiology 2018, 9: 1602. PMID: 30079055, PMCID: PMC6062601, DOI: 10.3389/fmicb.2018.01602.Peer-Reviewed Original ResearchHepatic transcriptional profilePreM groupGut microbiotaLiver steatosisNon-alcoholic fatty liver diseaseDietary weight loss programObesity-associated gut microbiotaLipid metabolismPeroxisome proliferator-activated receptor alphaProliferator-activated receptor alphaDysbiotic gut microbiotaLiver macrovesicular steatosisFatty liver diseaseNormal chow dietWeight loss programC57BL/6J male miceNormal hepatic physiologyObese human donorsLiver diseaseChow dietLoss programMice fedHuman gut microbiotaMacrovesicular steatosisMetabolic deterioration