2020
ANGPTL4: a multifunctional protein involved in metabolism and vascular homeostasis.
Fernández-Hernando C, Suárez Y. ANGPTL4: a multifunctional protein involved in metabolism and vascular homeostasis. Current Opinion In Hematology 2020, 27: 206-213. PMID: 32205586, PMCID: PMC9013473, DOI: 10.1097/moh.0000000000000580.Peer-Reviewed Original ResearchConceptsStem cell regulationPotential therapeutic targetLipid metabolismCell-specific functionsSpecific molecular eventsNonmetabolic functionsRegulatory circuitsMultifunctional proteinTherapeutic targetUnanticipated roleInvolvement of ANGPTL4Molecular eventsCell regulationPhysiological roleTherapeutic applicationsPredominant expressionVascular biologyPotential therapeutic applicationsVascular homeostasisPathophysiological conditionsDifferent disease settingsANGPTL4MetabolismFirst discoveryBiological effects
2018
MicroRNAs in endothelial cell homeostasis and vascular disease
Fernández-Hernando C, Suárez Y. MicroRNAs in endothelial cell homeostasis and vascular disease. Current Opinion In Hematology 2018, 25: 227-236. PMID: 29547400, PMCID: PMC6175704, DOI: 10.1097/moh.0000000000000424.Peer-Reviewed Original ResearchConceptsVascular diseaseVascular disease preventionPotential therapeutic targetEndothelial cell homeostasisEndothelial cell functionEndothelial dysfunctionEndothelial functionVascular dysfunctionTherapeutic applicationsPotential therapeutic applicationsInvolvement of miRNAsDysregulation of miRNAsEndothelial homeostasisTherapeutic targetDisease preventionDiseaseCell functionRegulatory circuitsCritical modulatorUnanticipated roleTarget genesCell homeostasisDysfunctionMiRNAsHomeostasis
2016
Micro-RNAs and High-Density Lipoprotein Metabolism
Canfrán-Duque A, Lin CS, Goedeke L, Suárez Y, Fernández-Hernando C. Micro-RNAs and High-Density Lipoprotein Metabolism. Arteriosclerosis Thrombosis And Vascular Biology 2016, 36: 1076-1084. PMID: 27079881, PMCID: PMC5315356, DOI: 10.1161/atvbaha.116.307028.BooksConceptsReverse cholesterol transportCardiovascular diseaseHDL metabolismCholesterol transportIschemic heart diseaseCause of deathEarlier epidemiological studiesPotential therapeutic targetBile acid synthesisMicro-RNAsCardioprotective effectsHeart diseaseEpidemiological studiesImproved preventionCholesterol effluxTherapeutic targetDensity lipoproteinCholesterol uptakeDiseaseArtery wallHDL biogenesisInverse correlationHDLLiverAcid synthesis
2015
miR-27b inhibits LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels in mice
Goedeke L, Rotllan N, Ramírez CM, Aranda JF, Canfrán-Duque A, Araldi E, Fernández-Hernando A, Langhi C, de Cabo R, Baldán Á, Suárez Y, Fernández-Hernando C. miR-27b inhibits LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels in mice. Atherosclerosis 2015, 243: 499-509. PMID: 26520906, PMCID: PMC4975922, DOI: 10.1016/j.atherosclerosis.2015.09.033.Peer-Reviewed Original ResearchMeSH Keywords3' Untranslated RegionsAdaptor Proteins, Signal TransducingAnimalsATP Binding Cassette Transporter 1BiomarkersChlorocebus aethiopsCholesterolComputational BiologyCOS CellsDatabases, GeneticDiet, High-FatGene Expression RegulationGene Regulatory NetworksHep G2 CellsHumansLiverMacaca mulattaMaleMice, Inbred C57BLMicroRNAsReceptors, LDLTime FactorsTransfectionTriglyceridesConceptsWild-type miceHepatic lipid levelsMiR-27b expressionLipid levelsHepatic lipidsABCA1 expressionMiR-27bWeeks of treatmentExpression of ABCA1Potential therapeutic targetABCA1 protein levelsCellular cholesterol effluxMiR-27b functionsMiR-27b overexpressionMouse hepatic cellsHepatic LDLRHepatic ABCA1Human hepatic Huh7 cellsHepatic cholesterolWestern dietCardiovascular diseaseTherapeutic administrationLDLR expressionTreatment groupsCholesterol efflux