2014
Autoregulation of glypican-1 by intronic microRNA-149 fine tunes the angiogenic response to FGF2 in human endothelial cells
Chamorro-Jorganes A, Araldi E, Rotllan N, Cirera-Salinas D, Suárez Y. Autoregulation of glypican-1 by intronic microRNA-149 fine tunes the angiogenic response to FGF2 in human endothelial cells. Journal Of Cell Science 2014, 127: 1169-1178. PMID: 24463821, PMCID: PMC3953812, DOI: 10.1242/jcs.130518.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, Lewis LungCells, CulturedFibroblast Growth Factor 2Gene ExpressionGlypicansHuman Umbilical Vein Endothelial CellsHumansMaleMiceMicroRNAsNeoplasm TransplantationNeovascularization, PathologicNeovascularization, PhysiologicReceptor, Fibroblast Growth Factor, Type 1RNA InterferenceSignal Transduction
2009
Cutting Edge: TNF-Induced MicroRNAs Regulate TNF-Induced Expression of E-Selectin and Intercellular Adhesion Molecule-1 on Human Endothelial Cells: Feedback Control of Inflammation
Suárez Y, Wang C, Manes TD, Pober JS. Cutting Edge: TNF-Induced MicroRNAs Regulate TNF-Induced Expression of E-Selectin and Intercellular Adhesion Molecule-1 on Human Endothelial Cells: Feedback Control of Inflammation. The Journal Of Immunology 2009, 184: 21-25. PMID: 19949084, PMCID: PMC2797568, DOI: 10.4049/jimmunol.0902369.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedEndothelial CellsE-SelectinFeedback, PhysiologicalGene ExpressionGene Expression RegulationHumansImmunohistochemistryInflammationIntercellular Adhesion Molecule-1MicroRNAsOligonucleotide Array Sequence AnalysisReverse Transcriptase Polymerase Chain ReactionTransfectionTumor Necrosis Factor-alphaConceptsEndothelial cellsGene expressionUntranslated regionHuman endothelial cellsMiRNAsCultured endothelial cellsTarget sequenceMicroRNA pairsNegative feedback controlMiR-31Adhesion moleculesCellsExpressionNeutrophil adhesionE-selectinAdhesion molecule-1AdhesionTransfectionIntercellular adhesion molecule-1MRNAMolecule-1SequenceEndothelial adhesion moleculesSpecific antagonismICAM-1
2007
Alloimmunity to Human Endothelial Cells Derived from Cord Blood Progenitors
Suárez Y, Shepherd BR, Rao DA, Pober JS. Alloimmunity to Human Endothelial Cells Derived from Cord Blood Progenitors. The Journal Of Immunology 2007, 179: 7488-7496. PMID: 18025193, DOI: 10.4049/jimmunol.179.11.7488.Peer-Reviewed Original ResearchConceptsCell-derived endothelial cellsEndothelial progenitor cellsCord blood endothelial progenitor cellsBlood endothelial progenitor cellsEndothelial cellsCord blood progenitorsExpression of proteinsMemory T cell responsesHuman endothelial cellsT cell responsesProgenitor cellsBlood progenitorsOrgan repairRegenerative medicineAllogeneic responseAdhesion moleculesTissue engineeringTissue sourcesMHC moleculesCell responsesSuch cellsCellsSame donorAlloimmunityVitroDicer Dependent MicroRNAs Regulate Gene Expression and Functions in Human Endothelial Cells
Suárez Y, Fernández-Hernando C, Pober JS, Sessa WC. Dicer Dependent MicroRNAs Regulate Gene Expression and Functions in Human Endothelial Cells. Circulation Research 2007, 100: 1164-1173. PMID: 17379831, DOI: 10.1161/01.res.0000265065.26744.17.Peer-Reviewed Original ResearchConceptsGene expressionHuman endothelial cellsEndogenous miRNA levelsImportance of miRNAsMaturation of microRNAsEC gene expressionEndothelial cellsTek/TieKnockdown of DicerDICER-dependent microRNAsRole of DicerMiRNA expression profilesKDR/VEGFR2MiR-222/221Dicer knockdownDependent microRNAsSynthase protein levelsDicerKey regulatorExpression profilesKey enzymePhysiological pathwaysCord formationEndothelial biologyMiRNAs
2006
Vascularization and engraftment of a human skin substitute using circulating progenitor cell‐derived endothelial cells
Shepherd BR, Enis DR, Wang F, Suarez Y, Pober JS, Schechner JS, Shepherd B, Enis D, Wang F, Suarez Y, Pober J, Scheduier J. Vascularization and engraftment of a human skin substitute using circulating progenitor cell‐derived endothelial cells. The FASEB Journal 2006, 20: 1739-1741. PMID: 16807367, DOI: 10.1096/fj.05-5682fje.Peer-Reviewed Original Research